Paper · 49107

Separate signals for the initiation of proliferation and differentiation in the b cell response to antigen.

Dutton RW. Transplant Rev, 1975. Cited by 185 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Separate signals for the initiation of proliferation and differentiation in the b cell response to antigen. Papers, record 49107. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/49107

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Separate signals for the initiation of proliferation and differentiation in the b cell response to antigen.; PubMed
Journal: Transplant Rev; PubMed
Year: 1975; PubMed
Publication types: Journal Article, Research Support, U.S. Gov't, P.H.S., Review; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/49107/; PubMed
DOI: https://doi.org/10.1111/j.1600-065x.1975.tb00149.x; PubMed
The journal: https://conductscience.org/library/journal-index/0215244; PubMed
Citations, by iCite: 185; iCite
Relative citation ratio, by iCite: 4.21; iCite
Revised in PubMed: 2019-10-27; PubMed

Authors1

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	Kind	ORCID iD
1	Dutton RW	R W

Source PubMed

Topics22

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Antigen-Antibody Reactions	Major topic
B-Lymphocytes	Major topic
Lymphocyte Activation	Major topic
Animals
Antibody Formation
Antibody-Producing Cells
Binding Sites, Antibody
Cell Differentiation
Cell Division
Cell Membrane
Cells, Cultured
Culture Media
Epitopes
Hemolytic Plaque Technique
Humans
Immunoglobulin G
Immunoglobulin M
Immunoglobulins
Mice
Mice, Inbred Strains
Mitogens
T-Lymphocytes

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References0

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

None in this release.

Cited by48

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 185 citations.

PMID	Title	Journal	Year	In Papers	Source
7,038,025	T cell-derived B cell differentiation factor(s). Effect on the isotype switch of murine B cells.	J Exp Med	1982	https://conductscience.org/library/papers/7038025	PubMed
7,000,683	A fraction (FAd) from Trypanosoma cruzi epimastigotes depresses the immune response in mice.	Immunology	1980	https://conductscience.org/library/papers/7000683	PubMed
6,983,561	Production of a B cell growth-promoting activity, (DL)BCGF, from a cloned T cell line and its assay on the BCL1 B cell tumor.	J Exp Med	1982	https://conductscience.org/library/papers/6983561	PubMed
6,979,606	A monoclonal T cell-replacing activity can act directly on B cells to enhance clonal expansion.	J Exp Med	1982	https://conductscience.org/library/papers/6979606	PubMed
6,975,350	Analysis of the response of B cells from CBA/N-defective mice to nonspecific T cell help.	J Exp Med	1981	https://conductscience.org/library/papers/6975350	PubMed
6,972,992	T lymphocyte-dependent B lymphocyte proliferative response to antigen. I Genetic restriction of the stimulation of B lymphocyte proliferation.	J Exp Med	1981	https://conductscience.org/library/papers/6972992	PubMed
6,967,509	Activation of murine B lymphocytes by anti-immunoglobulin is an inductive signal leading to immunoglobulin secretion.	J Exp Med	1980	https://conductscience.org/library/papers/6967509	PubMed
6,950,432	Specific cellular stimulation in the primary immune response: experimental test of a quantized model.	Proc Natl Acad Sci U S A	1982	https://conductscience.org/library/papers/6950432	PubMed
6,795,635	Long-term culture of normal mouse B lymphocytes.	Proc Natl Acad Sci U S A	1981	https://conductscience.org/library/papers/6795635	PubMed
6,609,362	Development of a human T-cell hybridoma secreting separate B-cell growth and differentiation factors.	Proc Natl Acad Sci U S A	1984	https://conductscience.org/library/papers/6609362	PubMed

1 to 10 of 48

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Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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