Paper · 6972992

T lymphocyte-dependent B lymphocyte proliferative response to antigen. I Genetic restriction of the stimulation of B lymphocyte proliferation.

Tse HY and 2 others. J Exp Med, 1981. Cited by 42 papers, by iCite.

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ConductScience Library. T lymphocyte-dependent B lymphocyte proliferative response to antigen. I Genetic restriction of the stimulation of B lymphocyte proliferation. Papers, record 6972992. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/6972992

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: T lymphocyte-dependent B lymphocyte proliferative response to antigen. I Genetic restriction of the stimulation of B lymphocyte proliferation.; PubMed
Journal: J Exp Med; PubMed
Year: 1981; PubMed
Publication types: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/6972992/; PubMed
DOI: https://doi.org/10.1084/jem.153.4.871; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC2186122/; PubMed
The journal: https://conductscience.org/library/journal-index/2985109R; PubMed
Citations, by iCite: 42; iCite
Relative citation ratio, by iCite: 0.96; iCite
Revised in PubMed: 2019-12-10; PubMed

Authors3

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Tse HY	H Y
2	Mond JJ	J J
3	Paul WE	W E

Source PubMed

Topics15

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Antigens	Major topic
B-Lymphocytes	Major topic
Lymphocyte Activation	Major topic
T-Lymphocytes	Major topic
Animals
Cell Count
Cells, Cultured
Dinitrobenzenes
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Ovalbumin
Peptides
Polymers
Tuberculin

Source PubMed

Grants0

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None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References20

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	6,034,749	Immunization of dissociated spleen cell cultures from normal mice.	J Exp Med	1967	https://conductscience.org/library/papers/6034749	PubMed
2	4,538,547	Proliferation by bone marrow-derived lymphocytes in response to antigenic stimulation in vitro.	J Immunol	1972	https://conductscience.org/library/papers/4538547	PubMed
3	4,126,766	Genetic control of immune responses in vitro. I. Development of primary and secondary plaque-forming cell responses to the random terpolymer 1-glutamic acid 60-1-alanine30-1-tyrosine10 (GAT) by mouse spleen cells in vitro.	J Exp Med	1973	https://conductscience.org/library/papers/4126766	PubMed
4	4,542,806	Function of macrophages in antigen recognition by guinea pig T lymphocytes. I. Requirement for histocompatible macrophages and lymphocytes.	J Exp Med	1973	https://conductscience.org/library/papers/4542806	PubMed
5	1,090,698	Cell interactions between histoincompatible T and B lymphocytes. VII. Cooperative responses between lymphocytes are controlled by genes in the I region of the H-2 complex.	J Exp Med	1975	https://conductscience.org/library/papers/1090698	PubMed
6	49,107	Separate signals for the initiation of proliferation and differentiation in the b cell response to antigen.	Transplant Rev	1975	https://conductscience.org/library/papers/49107	PubMed
7	1,083,419	Separation of helper and suppressor T lymphocytes on a ficoll velocity sedimentation gradient.	J Exp Med	1976	https://conductscience.org/library/papers/1083419	PubMed
8	1,087,318	The induction and regulation of guinea pig B-lymphocyte proliferation in vitro.	J Immunol	1976	https://conductscience.org/library/papers/1087318	PubMed
9	64,582	T-lymphocyte-enriched murine peritoneal exudate cells. IV. Genetic control of cross-stimulation at the T-cell level.	J Exp Med	1977	https://conductscience.org/library/papers/64582	PubMed
10	15,036	Mouse lymphocytes with and without surface immunoglobulin: preparative scale separation in polystyrene tissue culture dishes coated with specifically purified anti-immunoglobulin.	J Immunol Methods	1977	https://conductscience.org/library/papers/15036	PubMed

1 to 10 of 20

See all 20 references

Cited by10

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 42 citations.

PMID	Title	Journal	Year	In Papers	Source
6,980,255	Requirement for three signals in B cell responses. II. Analysis of antigen- and Ia-restricted T helper cell-B cell interaction.	J Exp Med	1982	https://conductscience.org/library/papers/6980255	PubMed
6,801,187	B lymphocyte immune response gene phenotype is genetically determined.	J Exp Med	1982	https://conductscience.org/library/papers/6801187	PubMed
6,605,533	Activation of antigen-specific B cells: role of T cells, cytokines, and antigen in induction of growth and differentiation.	Proc Natl Acad Sci U S A	1983	https://conductscience.org/library/papers/6605533	PubMed
6,238,333	Antigen-specific helper T-cell clone supernatant is sufficient to induce both polyclonal proliferation and differentiation of small resting B lymphocytes.	Proc Natl Acad Sci U S A	1984	https://conductscience.org/library/papers/6238333	PubMed
6,222,380	Monoclonal antibodies against HLA-DR antigens replace T helper cells in activation of B lymphocytes.	Proc Natl Acad Sci U S A	1983	https://conductscience.org/library/papers/6222380	PubMed
6,199,453	Polyclonal stimulation of resting B lymphocytes by antigen-specific T lymphocytes.	J Exp Med	1984	https://conductscience.org/library/papers/6199453	PubMed
6,187,688	Development of specific and cross-reactive lymphocyte proliferative responses during chronic immunizing infections with Rickettsia tsutsugamushi.	Infect Immun	1983	https://conductscience.org/library/papers/6187688	PubMed
6,185,433	Gamma-irradiated scrub typhus immunogens: development of cell-mediated immunity after vaccination of inbred mice.	Infect Immun	1983	https://conductscience.org/library/papers/6185433	PubMed
3,931,082	The murine bm12 gene conversion provides evidence that T cells recognize predominantly Ia conformation.	Proc Natl Acad Sci U S A	1985	https://conductscience.org/library/papers/3931082	PubMed
2,148,211	Method for identifying microbial antigens that stimulate specific lymphocyte responses: application to Salmonella.	Proc Natl Acad Sci U S A	1990	https://conductscience.org/library/papers/2148211	PubMed

Genes0

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None in this release.

Drugs0

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None in this release.

Data0

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Data dates

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PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

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ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

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ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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