Paper5723
Desensitization of beta-adrenergic receptors by beta-adrenergic agonists in a cell-free system: resensitization by guanosine 5'-(beta, gamma-imino)triphosphate and other purine nucleotides.
Mukherjee C and 1 other. Proc Natl Acad Sci U S A, 1976. Cited by 151 papers, by iCite.
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ConductScience Library. Desensitization of beta-adrenergic receptors by beta-adrenergic agonists in a cell-free system: resensitization by guanosine 5'-(beta, gamma-imino)triphosphate and other purine nucleotides. Papers, record 5723. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/5723
Paper
PubMed's record of the paper, with iCite's citation figures. No abstract is shown.
- Title
- Desensitization of beta-adrenergic receptors by beta-adrenergic agonists in a cell-free system: resensitization by guanosine 5'-(beta, gamma-imino)triphosphate and other purine nucleotides.
- PubMed
Topics16
NLM's MeSH indexing of the paper, its major topics first.
| MeSH term | Major |
|---|---|
| Adrenergic beta-Agonists | Major topic |
| Purine Nucleotides | Major topic |
| Receptors, Adrenergic | Major topic |
| Adenylyl Cyclases | |
| Alprenolol | |
| Animals | |
| Cell Membrane | |
| Cell-Free System | |
| Dose-Response Relationship, Drug | |
| Enzyme Activation | |
| Erythrocytes | |
| Guanosine Triphosphate | |
| Isoproterenol | |
| Kinetics | |
| Propranolol | |
| Structure-Activity Relationship |
Source PubMed
References14
The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.
| Order | PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|---|
| 1 | 1,057,183 | Catecholamine-induced subsensitivity of adenylate cyclase associated with loss of beta-adrenergic receptor binding sites. | Proc Natl Acad Sci U S A | 1975 | https://conductscience.org/library/papers/1057183 | PubMed |
| 2 | 1,059,161 | Rapid changes in rat pineal beta-adrenergic receptor: alterations in l-(3H)alprenolol binding and adenylate cyclase. | Proc Natl Acad Sci U S A | 1975 | https://conductscience.org/library/papers/1059161 | PubMed |
| 3 | 1,245,597 | Identification of beta-adrenergic receptors in human lymphocytes by (-) (3H) alprenolol binding. | J Clin Invest | 1976 | https://conductscience.org/library/papers/1245597 | PubMed |
| 5 | 167,023 | Subsensitivity of adenylate cyclase and decreased beta-adrenergic receptor binding after chronic exposure to (minus)-isoproterenol in vitro. | J Biol Chem | 1975 | https://conductscience.org/library/papers/167023 | PubMed |
| 6 | 171,653 | Human synoviocytes: activation and desensitization by prostaglandins and 1-epinephrine. | Proc Natl Acad Sci U S A | 1975 | https://conductscience.org/library/papers/171653 | PubMed |
| 7 | 238,972 | Identification of adenylate cyclase-coupled beta-adrenergic receptors in frog erythrocytes with (minus)-[3-H] alprenolol. | J Biol Chem | 1975 | https://conductscience.org/library/papers/238972 | PubMed |
| 8 | 238,988 | On the mechanism of activation of fat cell adenylate cyclase by guanine nucleotides. An explanation for the biphasic inhibitory and stimulatory effects of the nucleotides and the role of hormones. | J Biol Chem | 1975 | https://conductscience.org/library/papers/238988 | PubMed |
| 9 | 3,725 | Structure-activity relationships of adenylate cyclase-coupled beta adrenergic receptors: determination by direct binding studies. | Mol Pharmacol | 1976 | https://conductscience.org/library/papers/3725 | PubMed |
| 10 | 4,357,392 | Hormone-induced desensitisation of hormonal control of cyclic AMP levels in human diploid fibroblasts. | Nat New Biol | 1973 | https://conductscience.org/library/papers/4357392 | PubMed |
| 11 | 4,425,095 | Stimulation of catecholamine-sensitive adenylate cyclase by 5'-guanylyl-imidodiphosphate. | J Biol Chem | 1974 | https://conductscience.org/library/papers/4425095 | PubMed |
| 12 | 4,436,329 | Binding of 5'-guanylyl-imidodiphosphate to turkey erythrocyte membranes and effects on beta-adrenergic-activated adenylate cyclase. | J Biol Chem | 1974 | https://conductscience.org/library/papers/4436329 | PubMed |
| 13 | 4,607,368 | 5'-Guanylylimidodiphosphate, a potent activator of adenylate cyclase systems in eukaryotic cells. | Proc Natl Acad Sci U S A | 1974 | https://conductscience.org/library/papers/4607368 | PubMed |
| 14 | 4,827,395 | A highly sensitive adenylate cyclase assay. | Anal Biochem | 1974 | https://conductscience.org/library/papers/4827395 | PubMed |
| 15 | 4,927,674 | Conformational changes in ribosomes during protein synthesis. | Proc Natl Acad Sci U S A | 1971 | https://conductscience.org/library/papers/4927674 | PubMed |
Cited by21
The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 151 citations.
| PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|
| 33,116,795 | Nucleotides Cytidine and Uridine Associated with Vitamin B12 vs B-Complex Vitamins in the Treatment of Low Back Pain: The NUBES Study. | J Pain Res | 2020 | https://conductscience.org/library/papers/33116795 | PubMed |
| 16,943,583 | The dual effect of isoproterenol on insulin release is suppressed in pancreatic islets from hypothalamic obese rats. | Endocrine | 2006 | https://conductscience.org/library/papers/16943583 | PubMed |
| 12,365,800 | Immunoanalogue of vertebrate beta-adrenergic receptor in the unicellular eukaryote Paramecium. | Histochem J | 2002 | https://conductscience.org/library/papers/12365800 | PubMed |
| 10,605,451 | Morphological changes in rat pancreatic slices associated with inhibition of enzyme secretion by high concentrations of secretagogues. | J Cell Biol | 1978 | https://conductscience.org/library/papers/10605451 | PubMed |
| 7,436,995 | Time dependent partial loss of the effects of isoproterenol on function and energy metabolism of isolated rat hearts. | Basic Res Cardiol | 1980 | https://conductscience.org/library/papers/7436995 | PubMed |
| 7,393,346 | Regulation of the adenylate cyclase system by catecholamines in the rat prostate. | Naunyn Schmiedebergs Arch Pharmacol | 1980 | https://conductscience.org/library/papers/7393346 | PubMed |
| 6,302,675 | Unmasking of magnesium-dependent high-affinity binding sites for [dAla2, dLeu5]enkephalin after pretreatment of brain membranes with guanine nucleotides. | Proc Natl Acad Sci U S A | 1983 | https://conductscience.org/library/papers/6302675 | PubMed |
| 6,255,472 | Inhibiting the onset of hormone-induced desentiziation of viable thymocytes by N alpha-tosyl-L-lysine chloromethyl ketone. | Proc Natl Acad Sci U S A | 1980 | https://conductscience.org/library/papers/6255472 | PubMed |
| 6,253,990 | Interaction between beta-adrenergic receptors and guanine nucleotide sites in turkey erythrocyte membranes. | Proc Natl Acad Sci U S A | 1980 | https://conductscience.org/library/papers/6253990 | PubMed |
| 6,157,460 | Hormonal and nonhormonal desensitization in isolated bone cells. | Calcif Tissue Int | 1980 | https://conductscience.org/library/papers/6157460 | PubMed |
| 503,244 | Characteristics of histamine tachyphylaxis in canine tracheal smooth muscle. | Naunyn Schmiedebergs Arch Pharmacol | 1979 | https://conductscience.org/library/papers/503244 | PubMed |
| 233,264 | Hormonal regulation of peptide receptors and target cell responses. | Nature | 1979 | https://conductscience.org/library/papers/233264 | PubMed |
| 226,997 | Cholinergic activity regulates muscarinic receptors in central nervous system cultures. | Proc Natl Acad Sci U S A | 1979 | https://conductscience.org/library/papers/226997 | PubMed |
| 223,168 | Evidence for internalization of the recognition site of beta-adrenergic receptors during receptor subsensitivity induced by (-)-isoproterenol. | Proc Natl Acad Sci U S A | 1979 | https://conductscience.org/library/papers/223168 | PubMed |
| 209,244 | [New aspects of catecholamin-receptor interactions. Pathophysiological and clinical implications (author's transl)]. | Klin Wochenschr | 1978 | https://conductscience.org/library/papers/209244 | PubMed |
| 205,867 | Interaction of ligands with the opiate receptors of brain membranes: regulation by ions and nucleotides. | Proc Natl Acad Sci U S A | 1978 | https://conductscience.org/library/papers/205867 | PubMed |
| 201,530 | Lipolysis and cyclic AMP levels in epididymal adipose tissue of obese-hyperglycaemic mice. | Diabetologia | 1977 | https://conductscience.org/library/papers/201530 | PubMed |
| 197,522 | Topographic separation of adenylate cyclase and hormone receptors in the plasma membrane of toad erythrocyte ghosts. | Proc Natl Acad Sci U S A | 1977 | https://conductscience.org/library/papers/197522 | PubMed |
| 194,925 | Hormonal control of adrenocortical cell proliferation. Desensitization to ACTH and interaction between ACTH and fibroblast growth factor in bovine adrenocortical cell cultures. | J Clin Invest | 1977 | https://conductscience.org/library/papers/194925 | PubMed |
| 24,213 | Agonist-induced increase in apparent beta-adrenergic receptor size. | Proc Natl Acad Sci U S A | 1978 | https://conductscience.org/library/papers/24213 | PubMed |
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- 2026-11-11
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- 2026-09-18
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- ClinicalTrials.govNo license stated
- HGNCCC0
- iCiteCC BY 4.0
- NCBI GenePublic domain (US government)
- NIH RePORTER's grant and paper linksPublic domain
- Open TargetsCC0 1.0
- PMC's ID filePublic domain (US government)
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
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- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- HGNCCC0: https://www.genenames.org/about/license/
- iCiteCC BY 4.0
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
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