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Paper3725

Structure-activity relationships of adenylate cyclase-coupled beta adrenergic receptors: determination by direct binding studies.

Mukherjee C and 3 others. Mol Pharmacol, 1976. Cited by 122 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Structure-activity relationships of adenylate cyclase-coupled beta adrenergic receptors: determination by direct binding studies. Papers, record 3725. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/3725

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Structure-activity relationships of adenylate cyclase-coupled beta adrenergic receptors: determination by direct binding studies.
PubMed
Journal
Mol Pharmacol
PubMed
Year
1976
PubMed
Publication types
Journal Article, Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
122
iCite
Relative citation ratio, by iCite
4.26
iCite
Revised in PubMed
2015-11-19
PubMed

Authors4

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Mukherjee CC
2Caron MGM G
3Mullikin DD
4Lefkowitz RJR J

Source PubMed

Topics10

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Adenylyl CyclasesMajor topic
Receptors, AdrenergicMajor topic
Adrenergic beta-Agonists
Adrenergic beta-Antagonists
Animals
In Vitro Techniques
Kinetics
Protein Binding
Rana pipiens
Structure-Activity Relationship

Source PubMed

Cited by11

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 122 citations.

PMIDTitleJournalYearIn PapersSource
32,101,364p-Synephrine, ephedrine, p-octopamine and m-synephrine: Comparative mechanistic, physiological and pharmacological properties.Phytother Res2020https://conductscience.org/library/papers/32101364PubMed
28,752,649Safety, Efficacy, and Mechanistic Studies Regarding Citrus aurantium (Bitter Orange) Extract and p-Synephrine.Phytother Res2017https://conductscience.org/library/papers/28752649PubMed
21,740,415Use of inotropes and vasopressor agents in critically ill patients.Br J Pharmacol2012https://conductscience.org/library/papers/21740415PubMed
6,154,947Macromolecular beta-adrenergic antagonists discriminating between receptor and antibody.Proc Natl Acad Sci U S A1980https://conductscience.org/library/papers/6154947PubMed
231,201Biochemical characterization of the beta-adrenergic receptor of the frog erythrocyte.Mol Cell Biochem1979https://conductscience.org/library/papers/231201PubMed
37,448Beta-adrenoreceptors determine affinity but not intrinsic activity of adenylate cyclase stimulants.Nature1979https://conductscience.org/library/papers/37448PubMed
36,615Antibodies raised against purified beta-adrenergic receptors specifically bind beta-adrenergic ligands.Proc Natl Acad Sci U S A1979https://conductscience.org/library/papers/36615PubMed
18,249The use of functional antagonism to determine whether beta-adrenoceptor agonists must have a lower efficacy than isoprenaline to be trachea-atria selective in vitro in guinea-pigs.Br J Pharmacol1977https://conductscience.org/library/papers/18249PubMed
15,249Catecholamine binding to the beta-adrenergic receptor.Proc Natl Acad Sci U S A1977https://conductscience.org/library/papers/15249PubMed
13,086Ectopic beta-adrenergic receptor binding sites. possible molecular basis of aberrant catecholamine responsiveness of an adrenocortical tumor adenylate cyclase.J Clin Invest1977https://conductscience.org/library/papers/13086PubMed
5,723Desensitization of beta-adrenergic receptors by beta-adrenergic agonists in a cell-free system: resensitization by guanosine 5'-(beta, gamma-imino)triphosphate and other purine nucleotides.Proc Natl Acad Sci U S A1976https://conductscience.org/library/papers/5723PubMed

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

None in this release

  • Grants
  • Trials
  • Comments and corrections
  • References
  • Genes
  • Drugs
  • Data

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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