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Paper37448

Beta-adrenoreceptors determine affinity but not intrinsic activity of adenylate cyclase stimulants.

Pike LJ and 2 others. Nature, 1979. Cited by 23 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Beta-adrenoreceptors determine affinity but not intrinsic activity of adenylate cyclase stimulants. Papers, record 37448. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/37448

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Beta-adrenoreceptors determine affinity but not intrinsic activity of adenylate cyclase stimulants.
PubMed
Journal
Nature
PubMed
Year
1979
PubMed
Publication types
Journal Article, Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
23
iCite
Relative citation ratio, by iCite
0.83
iCite
Revised in PubMed
2026-10-10
PubMed

Authors3

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Pike LJL J
2Limbird LEL E
3Lefkowitz RJR J

Source PubMed

Topics13

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Adenylyl CyclasesMajor topic
Adrenergic beta-AgonistsMajor topic
Receptors, AdrenergicMajor topic
Receptors, Adrenergic, betaMajor topic
Animals
Anura
Cell Fusion
Epinephrine
Erythrocyte Membrane
Hybrid Cells
Isoproterenol
Norepinephrine
Turkeys

Source PubMed

References18

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
115,249Catecholamine binding to the beta-adrenergic receptor.Proc Natl Acad Sci U S A1977https://conductscience.org/library/papers/15249PubMed
23,725Structure-activity relationships of adenylate cyclase-coupled beta adrenergic receptors: determination by direct binding studies.Mol Pharmacol1976https://conductscience.org/library/papers/3725PubMed
3205,559Multiple effects of N, N' dicyclohexyl carbodiimide on the beta-adrenergic receptor--adenylate cyclase system in frog erythrocytes.J Cyclic Nucleotide Res1978https://conductscience.org/library/papers/205559PubMed
41,069,993Coupling of catecholamine receptor from one cell with adenylate cyclase from another cell by cell fusion.Proc Natl Acad Sci U S A1976https://conductscience.org/library/papers/1069993PubMed
54,827,395A highly sensitive adenylate cyclase assay.Anal Biochem1974https://conductscience.org/library/papers/4827395PubMed
6195,961Hydrodynamic properties of the beta-adrenergic receptor and adenylate cyclase from wild type and varient S49 lymphoma cells.J Biol Chem1977https://conductscience.org/library/papers/195961PubMed
7198,781Mechanism of adenylate cyclase activation by cholera toxin: inhibition of GTP hydrolysis at the regulatory site.Proc Natl Acad Sci U S A1977https://conductscience.org/library/papers/198781PubMed
8562,358Reconstitution of catecholamine-sensitive adenylate cyclase activity: interaction of components following cell-cell and membrane-cell fusion.J Cyclic Nucleotide Res1977https://conductscience.org/library/papers/562358PubMed
9198,799Reconstitution of catecholamine-sensitive adenylate cyclase activity: interactions of solubilized components with receptor-replete membranes.Proc Natl Acad Sci U S A1977https://conductscience.org/library/papers/198799PubMed
106,036,174Differentiation of receptor systems activated by sympathomimetic amines.Nature1967https://conductscience.org/library/papers/6036174PubMed
11196,212Coupling of hormone receptors to adenylate cyclase of different cells by cell fusion.Nature1977https://conductscience.org/library/papers/196212PubMed
124,425,095Stimulation of catecholamine-sensitive adenylate cyclase by 5'-guanylyl-imidodiphosphate.J Biol Chem1974https://conductscience.org/library/papers/4425095PubMed
13833,154Resolution of beta-adrenergic receptor binding and adenylate cyclase activity by gel exclusion chromatography.J Biol Chem1977https://conductscience.org/library/papers/833154PubMed
14934,056Regulation of adenylate cyclase-coupled beta adrenergic receptor binding sites by beta adrenergic catecholamines in vitro.Mol Pharmacol1976https://conductscience.org/library/papers/934056PubMed
15187,924Beta adrenergic receptors and adenylate cyclase: products of separate genes?Mol Pharmacol1976https://conductscience.org/library/papers/187924PubMed
1617,119Adenylate cyclase permanently uncoupled from hormone receptors in a novel variant of S49 mouse lymphoma cells.Proc Natl Acad Sci U S A1977https://conductscience.org/library/papers/17119PubMed
17197,949Activation of turkey erythrocyte adenylate cyclase and blocking of the catecholamine-stimulated GTPase by guanosine 5'-(gamma-thio) triphosphate.Biochem Biophys Res Commun1977https://conductscience.org/library/papers/197949PubMed
181,254,566Beta-Adrenergic receptor interactions. Direct comparison of receptor interaction and biological activity.J Biol Chem1976https://conductscience.org/library/papers/1254566PubMed

Cited by3

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 23 citations.

PMIDTitleJournalYearIn PapersSource
7,070,577The dopamine receptor adenylate cyclase complex: evidence for post recognition site involvement for the development of supersensitivity.Neurochem Res1982https://conductscience.org/library/papers/7070577PubMed
6,175,371Dissociation of beta-adrenoceptor-induced effects on amylase secretion and cyclic adenosine 3', 5' monophosphate accumulation.Br J Pharmacol1982https://conductscience.org/library/papers/6175371PubMed
2,072,893Mechanism of adenylate cyclase activation by the rat lung cytoplasmic factors.Mol Cell Biochem1991https://conductscience.org/library/papers/2072893PubMed

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

None in this release

  • Grants
  • Trials
  • Comments and corrections
  • Genes
  • Drugs
  • Data

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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