Paper18249
The use of functional antagonism to determine whether beta-adrenoceptor agonists must have a lower efficacy than isoprenaline to be trachea-atria selective in vitro in guinea-pigs.
O'Donnell SR and 1 other. Br J Pharmacol, 1977. Cited by 23 papers, by iCite.
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ConductScience Library. The use of functional antagonism to determine whether beta-adrenoceptor agonists must have a lower efficacy than isoprenaline to be trachea-atria selective in vitro in guinea-pigs. Papers, record 18249. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/18249
Paper
PubMed's record of the paper, with iCite's citation figures. No abstract is shown.
- Title
- The use of functional antagonism to determine whether beta-adrenoceptor agonists must have a lower efficacy than isoprenaline to be trachea-atria selective in vitro in guinea-pigs.
- PubMed
Topics14
NLM's MeSH indexing of the paper, its major topics first.
| MeSH term | Major |
|---|---|
| Adrenergic beta-Agonists | Major topic |
| Carbachol | Major topic |
| Heart | Major topic |
| Isoproterenol | Major topic |
| Trachea | Major topic |
| Animals | |
| Female | |
| Guinea Pigs | |
| Heart Atria | |
| Heart Rate | |
| In Vitro Techniques | |
| Muscle Contraction | |
| Muscle, Smooth | |
| Organ Specificity |
Source PubMed
References13
The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.
| Order | PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|---|
| 1 | 4,404,833 | An examination of some -adrenoreceptor stimulants for selectivity using the isolated trachea and atria of the guinea pig. | Eur J Pharmacol | 1972 | https://conductscience.org/library/papers/4404833 | PubMed |
| 2 | 4,458,848 | Potency and selectivity in vitro of compounds related to isoprenaline and orciprenaline on beta-adrenoceptors in the guinea-pig. | Br J Pharmacol | 1974 | https://conductscience.org/library/papers/4458848 | PubMed |
| 3 | 4,613 | Dissociation constants and relative efficacies of agonists acting on alpha adrenergic receptors in rabbit aorta. | J Pharmacol Exp Ther | 1976 | https://conductscience.org/library/papers/4613 | PubMed |
| 4 | 6,060,269 | Differentiation of receptors responsive to isoproterenol. | Life Sci | 1967 | https://conductscience.org/library/papers/6060269 | PubMed |
| 5 | 10,029 | The contribution of extraneuronal uptake to the trachea-blood vessel selectivity of beta-adrenoceptor stimulants in vitro in guinea-pigs. | Br J Pharmacol | 1976 | https://conductscience.org/library/papers/10029 | PubMed |
| 7 | 4,398,743 | Steric aspects of adrenergic drugs. XVI. Beta adrenergic receptors of guinea-pig atria and trachea. | J Pharmacol Exp Ther | 1971 | https://conductscience.org/library/papers/4398743 | PubMed |
| 8 | 3,725 | Structure-activity relationships of adenylate cyclase-coupled beta adrenergic receptors: determination by direct binding studies. | Mol Pharmacol | 1976 | https://conductscience.org/library/papers/3725 | PubMed |
| 9 | 4,147,331 | The model of functional interaction. I. Development and first check of a new model of functional synergism and antagonism. | Eur J Pharmacol | 1973 | https://conductscience.org/library/papers/4147331 | PubMed |
| 10 | 4,147,332 | The model of functional interaction. II. Experimental verification of a new model: the antagonism of beta-adrenoceptor stimulants and other agonists. | Eur J Pharmacol | 1973 | https://conductscience.org/library/papers/4147332 | PubMed |
| 11 | 4,148,441 | Letter: Salbutamol: agonistic and antagonistic activity at beta--adrenoceptor sites. | J Pharm Pharmacol | 1973 | https://conductscience.org/library/papers/4148441 | PubMed |
| 12 | 4,150,359 | Classification and properties of peripheral adrenergic receptors. | Br Med Bull | 1973 | https://conductscience.org/library/papers/4150359 | PubMed |
| 13 | 4,152,313 | Studies on the effects of enantiomers of soterenol, trimetoquinol and salbutamol on beta adrenergic receptors of isolated guinea-pig atria and trachea. | J Pharmacol Exp Ther | 1974 | https://conductscience.org/library/papers/4152313 | PubMed |
| 14 | 240,019 | On the use of functional antagonism to estimate dissociation constants for beta adrenergic receptor agonists in isolated guinea-pig trachea. | J Pharmacol Exp Ther | 1975 | https://conductscience.org/library/papers/240019 | PubMed |
Cited by13
The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 23 citations.
| PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|
| 7,284,693 | A test of the null equation for functional antagonism. | Br J Pharmacol | 1981 | https://conductscience.org/library/papers/7284693 | PubMed |
| 7,272,604 | Influence of tracheal contraction on relaxant effects in vitro of theophylline and isoprenaline. | Br J Pharmacol | 1981 | https://conductscience.org/library/papers/7272604 | PubMed |
| 6,131,720 | Relaxation of cat trachea by beta-adrenoceptor agonists can be mediated by both beta1- and beta2-adrenoceptors and potentiated by inhibitors of extraneuronal uptake. | Br J Pharmacol | 1983 | https://conductscience.org/library/papers/6131720 | PubMed |
| 6,116,509 | Dissociation constants of isoprenaline and orciprenaline and their relative efficacies on guinea-pig isolated atria determined by use of an irreversible beta-adrenoceptor antagonist. | Br J Pharmacol | 1981 | https://conductscience.org/library/papers/6116509 | PubMed |
| 6,103,723 | A study of some propranolol analogues for selective beta-adrenoceptor antagonism using A2 values on isolated trachea and atria from guinea-pig. | Br J Pharmacol | 1980 | https://conductscience.org/library/papers/6103723 | PubMed |
| 4,052,734 | The guinea-pig isolated bronchus for the in vitro study of small calibre airway reactivity. | Br J Pharmacol | 1985 | https://conductscience.org/library/papers/4052734 | PubMed |
| 2,869,414 | Binding of agonists and antagonists to beta-adrenoceptors in rat vas deferens: relationship to functional response. | Naunyn Schmiedebergs Arch Pharmacol | 1985 | https://conductscience.org/library/papers/2869414 | PubMed |
| 2,865,685 | Beta 1- and beta 2-adrenoceptor binding and functional response in right and left atria of rat heart. | Naunyn Schmiedebergs Arch Pharmacol | 1985 | https://conductscience.org/library/papers/2865685 | PubMed |
| 1,975,429 | Affinities of full agonists for cardiac beta-adrenoceptors calculated by use of in vitro desensitization. | Naunyn Schmiedebergs Arch Pharmacol | 1990 | https://conductscience.org/library/papers/1975429 | PubMed |
| 1,680,517 | Desensitization and functional antagonism by beta-adrenoceptor and muscarinic receptor agonists, respectively: a comparison with receptor alkylation for calculation of apparent agonist affinity. | Br J Pharmacol | 1991 | https://conductscience.org/library/papers/1680517 | PubMed |
| 719,272 | Estimation of dissociation constants and relative efficacies of isoprenaline, orciprenaline and terbutaline in guinea-pig isolated atria by use of functional antagonism [proceedings]. | Br J Pharmacol | 1978 | https://conductscience.org/library/papers/719272 | PubMed |
| 526,709 | Functional antagonism as a means of determining dissociation constants and relative efficacies of sympathomimetic amines in guinea-pig isolated atria. | Br J Pharmacol | 1979 | https://conductscience.org/library/papers/526709 | PubMed |
| 41,190 | The importance of choice of agonist in studies designed to predict beta 2 : beta 1 adrenoceptor selectivity of antagonists from pA2 values on guinea-pig trachea and atria. | Naunyn Schmiedebergs Arch Pharmacol | 1979 | https://conductscience.org/library/papers/41190 | PubMed |
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- 2026-09-18
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- PMC's ID filePublic domain (US government)
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
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- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
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