Paper4147331
The model of functional interaction. I. Development and first check of a new model of functional synergism and antagonism.
van den Brink FG. Eur J Pharmacol, 1973. Cited by 99 papers, by iCite.
11 sourcespapers-2026-11-12-0.1.0
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ConductScience Library. The model of functional interaction. I. Development and first check of a new model of functional synergism and antagonism. Papers, record 4147331. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/4147331
Paper
PubMed's record of the paper, with iCite's citation figures. No abstract is shown.
- Title
- The model of functional interaction. I. Development and first check of a new model of functional synergism and antagonism.
- PubMed
Topics11
NLM's MeSH indexing of the paper, its major topics first.
| MeSH term | Major |
|---|---|
| Drug Antagonism | Major topic |
| Drug Interactions | Major topic |
| Drug Synergism | Major topic |
| Models, Biological | Major topic |
| Binding, Competitive | |
| Dose-Response Relationship, Drug | |
| Histamine | |
| Histamine H1 Antagonists | |
| Mathematics | |
| Methacholine Compounds | |
| Receptors, Drug |
Source PubMed
Cited by20
The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 99 citations.
| PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|
| 40,661,085 | Pharmacological basis for medicinal use of Cymbopogon proximus Hochst. ex A. Rich. Essential oil in hyperactive gastrointestinal disorders. | Front Pharmacol | 2025 | https://conductscience.org/library/papers/40661085 | PubMed |
| 35,209,147 | In Silico and Ex Vivo Studies on the Spasmolytic Activities of Fenchone Using Isolated Guinea Pig Trachea. | Molecules | 2022 | https://conductscience.org/library/papers/35209147 | PubMed |
| 16,995,861 | Speed of onset of bronchodilator response to salbutamol inhaled via different devices in asthmatics: a bioassay based on functional antagonism. | Br J Clin Pharmacol | 2006 | https://conductscience.org/library/papers/16995861 | PubMed |
| 11,487,520 | A comparison of effects measured with isotonic and isometric recording: II. Concentration-effect curves for physiological antagonists. | Br J Pharmacol | 2001 | https://conductscience.org/library/papers/11487520 | PubMed |
| 8,818,358 | Analysis of the effects of alpha 1-adrenoceptor antagonists on noradrenaline-mediated contraction of rat small mesenteric artery. | Br J Pharmacol | 1996 | https://conductscience.org/library/papers/8818358 | PubMed |
| 8,564,269 | Regulation by phosphodiesterase isoenzymes of non-adrenergic non-cholinergic contraction in guinea-pig isolated main bronchus. | Br J Pharmacol | 1995 | https://conductscience.org/library/papers/8564269 | PubMed |
| 8,548,172 | Extended concentration-response curves used to reflect full agonist efficacies and receptor occupancy-response coupling ranges. | Br J Pharmacol | 1995 | https://conductscience.org/library/papers/8548172 | PubMed |
| 8,395,286 | Interactions between responses mediated by activation of adenosine A2 receptors and alpha 1-adrenoceptors in the rabbit isolated aorta. | Br J Pharmacol | 1993 | https://conductscience.org/library/papers/8395286 | PubMed |
| 7,521,260 | Evidence for differential roles of nitric oxide (NO) and hyperpolarization in endothelium-dependent relaxation of pig isolated coronary artery. | Br J Pharmacol | 1994 | https://conductscience.org/library/papers/7521260 | PubMed |
| 7,284,693 | A test of the null equation for functional antagonism. | Br J Pharmacol | 1981 | https://conductscience.org/library/papers/7284693 | PubMed |
| 7,284,692 | An analysis of functional antagonism and synergism. | Br J Pharmacol | 1981 | https://conductscience.org/library/papers/7284692 | PubMed |
| 4,155,485 | An analysis of the alpha- and beta-effects of isoprenaline on the isolated nictitating membraen. | Naunyn Schmiedebergs Arch Pharmacol | 1974 | https://conductscience.org/library/papers/4155485 | PubMed |
| 4,027,483 | Application of the operational model of agonism to establish conditions when functional antagonism may be used to estimate agonist dissociation constants. | Br J Pharmacol | 1985 | https://conductscience.org/library/papers/4027483 | PubMed |
| 3,840,396 | Experimental testing of Mackay's model for functional antagonism in the isolated costo-uterus of the rat. | Br J Pharmacol | 1985 | https://conductscience.org/library/papers/3840396 | PubMed |
| 1,723,152 | Mu and kappa opioid receptor modulation of 5-HT3 and NK-3 receptor-evoked release of acetylcholine from the guinea-pig ileum myenteric plexus. | Naunyn Schmiedebergs Arch Pharmacol | 1991 | https://conductscience.org/library/papers/1723152 | PubMed |
| 1,351,970 | Formoterol, fenoterol, and salbutamol as partial agonists for relaxation of maximally contracted guinea pig tracheae: comparison of relaxation with receptor binding. | Lung | 1992 | https://conductscience.org/library/papers/1351970 | PubMed |
| 719,272 | Estimation of dissociation constants and relative efficacies of isoprenaline, orciprenaline and terbutaline in guinea-pig isolated atria by use of functional antagonism [proceedings]. | Br J Pharmacol | 1978 | https://conductscience.org/library/papers/719272 | PubMed |
| 526,709 | Functional antagonism as a means of determining dissociation constants and relative efficacies of sympathomimetic amines in guinea-pig isolated atria. | Br J Pharmacol | 1979 | https://conductscience.org/library/papers/526709 | PubMed |
| 481,617 | The alteration by propranolol of the inotropic and bathmotropic effects of dihydro-ouabain on guinea-pig papillary muscle. | Naunyn Schmiedebergs Arch Pharmacol | 1979 | https://conductscience.org/library/papers/481617 | PubMed |
| 18,249 | The use of functional antagonism to determine whether beta-adrenoceptor agonists must have a lower efficacy than isoprenaline to be trachea-atria selective in vitro in guinea-pigs. | Br J Pharmacol | 1977 | https://conductscience.org/library/papers/18249 | PubMed |
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- 2026-11-12
- Gene search
- 2026-11-11
- Pipelines
- 2026-09-18
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Sources 11
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- HGNCCC0
- iCiteCC BY 4.0
- NCBI GenePublic domain (US government)
- NIH RePORTER's grant and paper linksPublic domain
- Open TargetsCC0 1.0
- PMC's ID filePublic domain (US government)
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- HGNCCC0: https://www.genenames.org/about/license/
- iCiteCC BY 4.0
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
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