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Paper526709

Functional antagonism as a means of determining dissociation constants and relative efficacies of sympathomimetic amines in guinea-pig isolated atria.

Broadley KJ and 1 other. Br J Pharmacol, 1979. Cited by 30 papers, by iCite.

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ConductScience Library. Functional antagonism as a means of determining dissociation constants and relative efficacies of sympathomimetic amines in guinea-pig isolated atria. Papers, record 526709. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/526709

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Functional antagonism as a means of determining dissociation constants and relative efficacies of sympathomimetic amines in guinea-pig isolated atria.
PubMed
Journal
Br J Pharmacol
PubMed
Year
1979
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
30
iCite
Relative citation ratio, by iCite
1.47
iCite
Revised in PubMed
2019-05-09
PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Broadley KJK J
2Nicholson CDC D

Source PubMed

Topics12

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Myocardial ContractionMajor topic
SympathomimeticsMajor topic
Animals
Chemical Phenomena
Chemistry
Female
Guinea Pigs
Heart Rate
In Vitro Techniques
Male
Stimulation, Chemical
Structure-Activity Relationship

Source PubMed

References20

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
223,978
The contribution of metabolism to the hypothermia-induced supersensitivity of guinea-pig isolated atria; selective supersensitivity for beta-adrenoceptor agonists and their positive inotropic responses.
Gen Pharmacol1977https://conductscience.org/library/papers/23978PubMed
324,540Studies on beta-adrenoceptors mediating changes in mechanical events and adenosine 3',5'-monophosphate levels. Rat atria.Eur J Pharmacol1978https://conductscience.org/library/papers/24540PubMed
423,191The beta-adrenoceptor stimulant properties of OPC-2009 on guinea-pig isolated tracheal, right atrial and left atrial preparations.Br J Pharmacol1977https://conductscience.org/library/papers/23191PubMed
519,116A potent new beta2-adrenoceptor blocking agent.Br J Pharmacol1977https://conductscience.org/library/papers/19116PubMed
618,249The use of functional antagonism to determine whether beta-adrenoceptor agonists must have a lower efficacy than isoprenaline to be trachea-atria selective in vitro in guinea-pigs.Br J Pharmacol1977https://conductscience.org/library/papers/18249PubMed
721,238Evidence from agonist and antagonist studies to suggest that the beta1-adrenoceptors subserving the positive inotropic and chronotropic responses of the heart do not belong to two separate subgroups.J Pharm Pharmacol1977https://conductscience.org/library/papers/21238PubMed
8837,007Selective reserpine-induced supersensitivity of the positive inotropic and chronotropic responses to isoprenaline and salbutamol in guinea-pig isolated atria.Br J Pharmacol1977https://conductscience.org/library/papers/837007PubMed
91,234,763Differential blockade of guinea-pig atrial rate and force responses to (--)-noradrenaline by practolol - an uptake phenomenon.Eur J Pharmacol1975https://conductscience.org/library/papers/1234763PubMed
10240,019On the use of functional antagonism to estimate dissociation constants for beta adrenergic receptor agonists in isolated guinea-pig trachea.J Pharmacol Exp Ther1975https://conductscience.org/library/papers/240019PubMed
114,154,764Comparison of beta-adrenergic blocking activities of propranolol, isopropylmethoxamine, sotalol, practolol, alprenolol, pindolol, oxprenolol and D-32 in the atria and trachea of the guinea-pig.Arzneimittelforschung1974https://conductscience.org/library/papers/4154764PubMed
124,394,343A quantitative study of beta-adrenergic receptors in rabbit atria.Eur J Pharmacol1970https://conductscience.org/library/papers/4394343PubMed
134,391,750A comparison of the beta-adrenoreceptor stimulant properties of isoprenaline, with those of orciprenaline, salbutamol, soterenol and trimetoquinol on isolated atria and trachea of the guinea pig.J Pharm Pharmacol1970https://conductscience.org/library/papers/4391750PubMed
144,147,331The model of functional interaction. I. Development and first check of a new model of functional synergism and antagonism.Eur J Pharmacol1973https://conductscience.org/library/papers/4147331PubMed
154,382,727Evaluation of the cardiac effects of several beta adrenergic blocking agents.Ann N Y Acad Sci1967https://conductscience.org/library/papers/4382727PubMed
164,613Dissociation constants and relative efficacies of agonists acting on alpha adrenergic receptors in rabbit aorta.J Pharmacol Exp Ther1976https://conductscience.org/library/papers/4613PubMed
17238,222Indications for the existence of two types of cardiac beta-adrenergic receptors.Pharmacol Res Commun1975https://conductscience.org/library/papers/238222PubMed
184,554,480Cardiovascular and renal actions of dopamine: potential clinical applications.Pharmacol Rev1972https://conductscience.org/library/papers/4554480PubMed
19234,805Dobutamine: development of a new catecholamine to selectively increase cardiac contractility.Circ Res1975https://conductscience.org/library/papers/234805PubMed
204,715,216Differential inotropic--chronotropic action of thyronamine.Eur J Pharmacol1973https://conductscience.org/library/papers/4715216PubMed
215,232,334The pharmacological differentiation of adrenergic receptors.Ann N Y Acad Sci1967https://conductscience.org/library/papers/5232334PubMed

Cited by9

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 30 citations.

PMIDTitleJournalYearIn PapersSource
11,487,517Functional characterization of coronary vascular adenosine receptors in the mouse.Br J Pharmacol2001https://conductscience.org/library/papers/11487517PubMed
8,548,172Extended concentration-response curves used to reflect full agonist efficacies and receptor occupancy-response coupling ranges.Br J Pharmacol1995https://conductscience.org/library/papers/8548172PubMed
7,284,692An analysis of functional antagonism and synergism.Br J Pharmacol1981https://conductscience.org/library/papers/7284692PubMed
6,140,043Temperature-induced changes in dissociation constants (KA) of agonists at cardiac beta-adrenoceptors determined by use of the irreversible antagonist Ro 03-7894.Br J Pharmacol1983https://conductscience.org/library/papers/6140043PubMed
6,132,819Ventilatory and haemodynamic effects of prenalterol and terbutaline in asthmatic patients.Eur J Clin Pharmacol1983https://conductscience.org/library/papers/6132819PubMed
6,116,509Dissociation constants of isoprenaline and orciprenaline and their relative efficacies on guinea-pig isolated atria determined by use of an irreversible beta-adrenoceptor antagonist.Br J Pharmacol1981https://conductscience.org/library/papers/6116509PubMed
4,027,483Application of the operational model of agonism to establish conditions when functional antagonism may be used to estimate agonist dissociation constants.Br J Pharmacol1985https://conductscience.org/library/papers/4027483PubMed
1,975,429Affinities of full agonists for cardiac beta-adrenoceptors calculated by use of in vitro desensitization.Naunyn Schmiedebergs Arch Pharmacol1990https://conductscience.org/library/papers/1975429PubMed
1,680,517Desensitization and functional antagonism by beta-adrenoceptor and muscarinic receptor agonists, respectively: a comparison with receptor alkylation for calculation of apparent agonist affinity.Br J Pharmacol1991https://conductscience.org/library/papers/1680517PubMed

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

None in this release

  • Grants
  • Trials
  • Comments and corrections
  • Genes
  • Drugs
  • Data

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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