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Paper8564269

Regulation by phosphodiesterase isoenzymes of non-adrenergic non-cholinergic contraction in guinea-pig isolated main bronchus.

Spina D and 2 others. Br J Pharmacol, 1995. Cited by 32 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Regulation by phosphodiesterase isoenzymes of non-adrenergic non-cholinergic contraction in guinea-pig isolated main bronchus. Papers, record 8564269. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/8564269

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Regulation by phosphodiesterase isoenzymes of non-adrenergic non-cholinergic contraction in guinea-pig isolated main bronchus.
PubMed
Journal
Br J Pharmacol
PubMed
Year
1995
PubMed
Publication types
Journal Article, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
32
iCite
Relative citation ratio, by iCite
1.17
iCite
Revised in PubMed
2019-05-12
PubMed

Authors3

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Spina DD
2Harrison SS
3Page CPC P

Source PubMed

Topics15

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Autonomic Nervous SystemMajor topic
BronchiMajor topic
IsoenzymesMajor topic
Phosphoric Diester HydrolasesMajor topic
Animals
Electric Stimulation
Guinea Pigs
In Vitro Techniques
Male
Muscle Contraction
Muscle Relaxation
Neurons, Afferent
Neuropeptides
Phosphodiesterase Inhibitors
Substance P

Source PubMed

References40

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
18,004,382Separation and characterization of a novel isoenzyme of cyclic nucleotide phosphodiesterase from rat cerebrum.Br J Pharmacol1994https://conductscience.org/library/papers/8004382PubMed
28,003,849Inhibitors of cyclic nucleotide phosphodiesterase isoenzymes--their potential utility in the therapy of asthma.Pulm Pharmacol1994https://conductscience.org/library/papers/8003849PubMed
34,147,331The model of functional interaction. I. Development and first check of a new model of functional synergism and antagonism.Eur J Pharmacol1973https://conductscience.org/library/papers/4147331PubMed
44,147,332The model of functional interaction. II. Experimental verification of a new model: the antagonism of beta-adrenoceptor stimulants and other agonists.Eur J Pharmacol1973https://conductscience.org/library/papers/4147332PubMed
5230,542I - Prostaglandin hyperalgesia, a cAMP/Ca2+ dependent process.Prostaglandins1979https://conductscience.org/library/papers/230542PubMed
63,534,062Development of safer xanthine drugs for treatment of obstructive airways disease.J Allergy Clin Immunol1986https://conductscience.org/library/papers/3534062PubMed
73,683,597Peripheral effects of opioid drugs on capsaicin-sensitive neurones of the guinea-pig bronchus and rabbit ear.Naunyn Schmiedebergs Arch Pharmacol1987https://conductscience.org/library/papers/3683597PubMed
83,683,864The mechanism of action of capsaicin on sensory C-type neurons and their axons in vitro.Neuroscience1987https://conductscience.org/library/papers/3683864PubMed
93,171,675Capsaicin-induced ion fluxes in dorsal root ganglion cells in culture.J Neurosci1988https://conductscience.org/library/papers/3171675PubMed
102,460,772
The effect of omega conotoxin GVIA, a peptide modulator of the N-type voltage sensitive calcium channels, on motor responses produced by activation of efferent and sensory nerves in mammalian smooth muscle.
Naunyn Schmiedebergs Arch Pharmacol1988https://conductscience.org/library/papers/2460772PubMed
112,905,667Evidence for two independent modes of activation of the 'efferent' function of capsaicin-sensitive nerves.Eur J Pharmacol1988https://conductscience.org/library/papers/2905667PubMed
122,907,913Neuropeptide Y modulates neurotransmitter release and Ca2+ currents in rat sensory neurons.J Neurosci1988https://conductscience.org/library/papers/2907913PubMed
133,249,235The effect of down regulation of protein kinase C on the inhibitory modulation of dorsal root ganglion neuron Ca2+ currents by neuropeptide Y.J Neurosci1988https://conductscience.org/library/papers/3249235PubMed
143,249,246Depolarization of nonmyelinated fibers of the rat vagus nerve produced by activation of protein kinase C.J Neurosci1988https://conductscience.org/library/papers/3249246PubMed
152,472,969Modulatory action of galanin on responses due to antidromic activation of peripheral terminals of capsaicin-sensitive sensory nerves.Eur J Pharmacol1989https://conductscience.org/library/papers/2472969PubMed
162,745,277Adenosine selectively inhibits noncholinergic transmission in guinea pig bronchi.J Appl Physiol (1985)1989https://conductscience.org/library/papers/2745277PubMed
172,550,823Regulation of Ca2+-dependent K+-channel activity in tracheal myocytes by phosphorylation.Nature1989https://conductscience.org/library/papers/2550823PubMed
182,819,327Prejunctional modulatory action of neuropeptide Y on peripheral terminals of capsaicin-sensitive sensory nerves.Br J Pharmacol1989https://conductscience.org/library/papers/2819327PubMed
192,159,198Primary sequence of cyclic nucleotide phosphodiesterase isozymes and the design of selective inhibitors.Trends Pharmacol Sci1990https://conductscience.org/library/papers/2159198PubMed
201,700,817Selective inhibition of relaxation of guinea-pig trachea by charybdotoxin, a potent Ca(++)-activated K+ channel inhibitor.J Pharmacol Exp Ther1990https://conductscience.org/library/papers/1700817PubMed

See all 40 references

Cited by7

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 32 citations.

PMIDTitleJournalYearIn PapersSource
19,655,107Sensory nerves and airway irritability.Handb Exp Pharmacol2009https://conductscience.org/library/papers/19655107PubMed
18,660,825PDE4 inhibitors: current status.Br J Pharmacol2008https://conductscience.org/library/papers/18660825PubMed
14,636,078Phosphodiesterase-4 inhibitors in the treatment of inflammatory lung disease.Drugs2003https://conductscience.org/library/papers/14636078PubMed
11,226,144The endogenous cannabinoid agonist, anandamide stimulates sensory nerves in guinea-pig airways.Br J Pharmacol2001https://conductscience.org/library/papers/11226144PubMed
10,704,053Reduced airway hyperresponsiveness by phosphodiesterase 3 and 4 inhibitors in guinea-pigs.Mediators Inflamm1999https://conductscience.org/library/papers/10704053PubMed
8,818,344Effect of the glucocorticosteroid budesonide and a novel phosphodiesterase type 4 inhibitor CDP840 on antigen-induced airway responses in neonatally immunised rabbits.Br J Pharmacol1996https://conductscience.org/library/papers/8818344PubMed
8,730,732Effects of theophylline and rolipram on antigen-induced airway responses in neonatally immunized rabbits.Br J Pharmacol1996https://conductscience.org/library/papers/8730732PubMed

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

None in this release

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  • Trials
  • Comments and corrections
  • Genes
  • Drugs
  • Data

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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