Paper41190
The importance of choice of agonist in studies designed to predict beta 2 : beta 1 adrenoceptor selectivity of antagonists from pA2 values on guinea-pig trachea and atria.
O'Donnell SR and 1 other. Naunyn Schmiedebergs Arch Pharmacol, 1979. Cited by 175 papers, by iCite.
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ConductScience Library. The importance of choice of agonist in studies designed to predict beta 2 : beta 1 adrenoceptor selectivity of antagonists from pA2 values on guinea-pig trachea and atria. Papers, record 41190. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/41190
Paper
PubMed's record of the paper, with iCite's citation figures. No abstract is shown.
- Title
- The importance of choice of agonist in studies designed to predict beta 2 : beta 1 adrenoceptor selectivity of antagonists from pA2 values on guinea-pig trachea and atria.
- PubMed
Topics13
NLM's MeSH indexing of the paper, its major topics first.
| MeSH term | Major |
|---|---|
| Adrenergic beta-Agonists | Major topic |
| Adrenergic beta-Antagonists | Major topic |
| Muscle Contraction | Major topic |
| Myocardial Contraction | Major topic |
| Receptors, Adrenergic | Major topic |
| Receptors, Adrenergic, beta | Major topic |
| Trachea | Major topic |
| Animals | |
| Drug Interactions | |
| Female | |
| Guinea Pigs | |
| In Vitro Techniques | |
| Muscle, Smooth |
Source PubMed
References22
The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.
| Order | PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|---|
| 1 | 47,291 | Beta-adrenoceptors invloved in inhibition of histamine release from sensitized guinea-pig lung. | Eur J Pharmacol | 1975 | https://conductscience.org/library/papers/47291 | PubMed |
| 2 | 13,651,579 | Some quantitative uses of drug antagonists. | Br J Pharmacol Chemother | 1959 | https://conductscience.org/library/papers/13651579 | PubMed |
| 3 | 4,458,848 | Potency and selectivity in vitro of compounds related to isoprenaline and orciprenaline on beta-adrenoceptors in the guinea-pig. | Br J Pharmacol | 1974 | https://conductscience.org/library/papers/4458848 | PubMed |
| 4 | 4,145,321 | Influence of N-alkyl substitution on antagonism at 1 - and 2 -receptor sites. | Eur J Pharmacol | 1973 | https://conductscience.org/library/papers/4145321 | PubMed |
| 5 | 18,249 | The use of functional antagonism to determine whether beta-adrenoceptor agonists must have a lower efficacy than isoprenaline to be trachea-atria selective in vitro in guinea-pigs. | Br J Pharmacol | 1977 | https://conductscience.org/library/papers/18249 | PubMed |
| 6 | 4,394,346 | A selective beta-adrenoreceptor stimulant (Th1165a) related to orciprenaline. | Eur J Pharmacol | 1970 | https://conductscience.org/library/papers/4394346 | PubMed |
| 7 | 6,103,723 | A study of some propranolol analogues for selective beta-adrenoceptor antagonism using A2 values on isolated trachea and atria from guinea-pig. | Br J Pharmacol | 1980 | https://conductscience.org/library/papers/6103723 | PubMed |
| 8 | 4,152,806 | Changes in beta-adrenoceptor-blocking activity produced by chemical modifications in the practolol molecule. | Eur J Pharmacol | 1974 | https://conductscience.org/library/papers/4152806 | PubMed |
| 9 | 928,267 | The pharmacology of atenolol. | Postgrad Med J | 1977 | https://conductscience.org/library/papers/928267 | PubMed |
| 10 | 837,007 | Selective reserpine-induced supersensitivity of the positive inotropic and chronotropic responses to isoprenaline and salbutamol in guinea-pig isolated atria. | Br J Pharmacol | 1977 | https://conductscience.org/library/papers/837007 | PubMed |
| 12 | 4,151,237 | Guinea-pig atrial and pulmonary beta-adrenoceptors. | Arch Int Pharmacodyn Ther | 1974 | https://conductscience.org/library/papers/4151237 | PubMed |
| 13 | 719,958 | The antagonism by propranolol and alpha-methylpropranolol (ICI 77602) of vascular and cardiac responses to isoprenaline in anaesthetized dogs. | Clin Exp Pharmacol Physiol | 1978 | https://conductscience.org/library/papers/719958 | PubMed |
| 14 | 4,404,833 | An examination of some -adrenoreceptor stimulants for selectivity using the isolated trachea and atria of the guinea pig. | Eur J Pharmacol | 1972 | https://conductscience.org/library/papers/4404833 | PubMed |
| 15 | 5,772,673 | An analysis of selective beta receptor blockade. | Eur J Pharmacol | 1969 | https://conductscience.org/library/papers/5772673 | PubMed |
| 16 | 240,019 | On the use of functional antagonism to estimate dissociation constants for beta adrenergic receptor agonists in isolated guinea-pig trachea. | J Pharmacol Exp Ther | 1975 | https://conductscience.org/library/papers/240019 | PubMed |
| 17 | 19,116 | A potent new beta2-adrenoceptor blocking agent. | Br J Pharmacol | 1977 | https://conductscience.org/library/papers/19116 | PubMed |
| 18 | 41,041 | pA2 values of selective beta-adrenoceptor antagonists on isolated atria demonstrate a species difference in the beta-adrenoceptor populations mediating chronotropic responses in cat and guinea-pig. | J Pharm Pharmacol | 1979 | https://conductscience.org/library/papers/41041 | PubMed |
| 19 | 24,690 | Possible differences in alpha-adrenoceptors in rabbit ileum and spleen. | J Pharm Pharmacol | 1978 | https://conductscience.org/library/papers/24690 | PubMed |
| 20 | 4,149,462 | Selective beta adrenergic receptor antagonism in the anesthetized dog. | J Pharmacol Exp Ther | 1974 | https://conductscience.org/library/papers/4149462 | PubMed |
| 21 | 26,747 | How should values of pA2 and affinity constants for pharmacological competitive antagonists be estimated? | J Pharm Pharmacol | 1978 | https://conductscience.org/library/papers/26747 | PubMed |
Cited by38
The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 175 citations.
| PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|
| 39,382,679 | The negative chronotropic effects of (±)-propranolol and (±)-4-NO2-propranolol in the rat isolated right atrium are due to blockade of the 6-nitrodopamine receptor. | Naunyn Schmiedebergs Arch Pharmacol | 2025 | https://conductscience.org/library/papers/39382679 | PubMed |
| 29,540,623 | Pharmacological identification of β-adrenoceptor subtypes mediating isoprenaline-induced relaxation of guinea pig colonic longitudinal smooth muscle. | J Smooth Muscle Res | 2018 | https://conductscience.org/library/papers/29540623 | PubMed |
| 21,323,900 | The design, synthesis and pharmacological characterization of novel β₂-adrenoceptor antagonists. | Br J Pharmacol | 2011 | https://conductscience.org/library/papers/21323900 | PubMed |
| 17,237,919 | Pharmacological characterization of the beta-adrenoceptor that mediates the relaxant response to noradrenaline in guinea-pig tracheal smooth muscle. | Naunyn Schmiedebergs Arch Pharmacol | 2007 | https://conductscience.org/library/papers/17237919 | PubMed |
| 8,872,350 | Capsinolol: the first beta-adrenoceptor blocker with an associated calcitonin gene-related peptide releasing activity in the heart. | Br J Pharmacol | 1996 | https://conductscience.org/library/papers/8872350 | PubMed |
| 8,095,419 | Investigations into factors determining the duration of action of the beta 2-adrenoceptor agonist, salmeterol. | Br J Pharmacol | 1993 | https://conductscience.org/library/papers/8095419 | PubMed |
| 8,032,617 | Pharmacological characterization and anatomical localization of prejunctional beta-adrenoceptors in the rat kidney. | Br J Pharmacol | 1994 | https://conductscience.org/library/papers/8032617 | PubMed |
| 7,915,610 | Effect of salmeterol on human nasal epithelial cell ciliary beating: inhibition of the ciliotoxin, pyocyanin. | Br J Pharmacol | 1994 | https://conductscience.org/library/papers/7915610 | PubMed |
| 7,675,115 | Beta-adrenoceptor regulation and functional responses in the guinea-pig following chronic administration of the long-acting beta 2-adrenoceptor agonist formoterol. | Naunyn Schmiedebergs Arch Pharmacol | 1995 | https://conductscience.org/library/papers/7675115 | PubMed |
| 7,284,696 | Proceedings of the British Pharmacological Society. 16--18th December, 1980. | Br J Pharmacol | 1981 | https://conductscience.org/library/papers/7284696 | PubMed |
| 6,317,123 | Beta-adrenoceptor heterogeneity in guinea-pig airways: comparison of functional and receptor labelling studies. | Br J Pharmacol | 1983 | https://conductscience.org/library/papers/6317123 | PubMed |
| 6,307,451 | Classification of beta-adrenoceptors in isolated bronchus of the pig. | Br J Pharmacol | 1983 | https://conductscience.org/library/papers/6307451 | PubMed |
| 6,289,139 | A novel analysis of concentration-dependence of partial agonism Ring-demethylation of bupranolol results in a high affinity partial agonist (K 105) for myocardial and tracheal beta-adrenoceptors. | Naunyn Schmiedebergs Arch Pharmacol | 1982 | https://conductscience.org/library/papers/6289139 | PubMed |
| 6,286,028 | A comparative study of beta-adrenoceptors in human and porcine lung parenchyma strip. | Br J Pharmacol | 1982 | https://conductscience.org/library/papers/6286028 | PubMed |
| 6,144,344 | The classification of beta-adrenoceptors in isolated ring preparations of canine coronary arteries. | Br J Pharmacol | 1984 | https://conductscience.org/library/papers/6144344 | PubMed |
| 6,144,342 | Classification of beta-adrenoceptors in human isolated bronchus. | Br J Pharmacol | 1984 | https://conductscience.org/library/papers/6144342 | PubMed |
| 6,140,058 | The selectivity of beta-adrenoceptor antagonists on isoprenaline-induced changes in heart rate, blood pressure, soleus muscle contractility and airways function in anaesthetized cats. | Br J Pharmacol | 1983 | https://conductscience.org/library/papers/6140058 | PubMed |
| 6,135,158 | A model for the interaction of competitive antagonists with two receptor-subtypes characterized by a Schild-plot with apparent slope unity. Agonist-dependent enantiomeric affinity ratios for bupranolol in tracheae but not in right atria of guinea pigs. | Naunyn Schmiedebergs Arch Pharmacol | 1983 | https://conductscience.org/library/papers/6135158 | PubMed |
| 6,133,574 | Comparison of the chronotropic effect and the cyclic AMP accumulation induced by beta 2-agonists in rat heart cell culture. | Br J Pharmacol | 1983 | https://conductscience.org/library/papers/6133574 | PubMed |
| 6,131,720 | Relaxation of cat trachea by beta-adrenoceptor agonists can be mediated by both beta1- and beta2-adrenoceptors and potentiated by inhibitors of extraneuronal uptake. | Br J Pharmacol | 1983 | https://conductscience.org/library/papers/6131720 | PubMed |
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