Paper6133574

Comparison of the chronotropic effect and the cyclic AMP accumulation induced by beta 2-agonists in rat heart cell culture.

Freyss-Beguin M and 6 others. Br J Pharmacol, 1983. Cited by 22 papers, by iCite.

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ConductScience Library. Comparison of the chronotropic effect and the cyclic AMP accumulation induced by beta 2-agonists in rat heart cell culture. Papers, record 6133574. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/6133574

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Comparison of the chronotropic effect and the cyclic AMP accumulation induced by beta 2-agonists in rat heart cell culture.; PubMed
Journal: Br J Pharmacol; PubMed
Year: 1983; PubMed
Publication types: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/6133574/; PubMed
DOI: https://doi.org/10.1111/j.1476-5381.1983.tb09425.x; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC2044749/; PubMed
The journal: https://conductscience.org/library/journal-index/7502536; PubMed
Citations, by iCite: 22; iCite
Relative citation ratio, by iCite: 0.82; iCite
Revised in PubMed: 2019-05-11; PubMed

Authors7

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Freyss-Beguin M	M
2	Griffaton G	G
3	Lechat P	P
4	Picken D	D
5	Quennedey MC	M C
6	Rouot B	B
7	Schwartz J	J

Source PubMed

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Topics10

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Adrenergic beta-Agonists	Major topic
Cyclic AMP	Major topic
Heart Rate	Major topic
Myocardium	Major topic
Animals
Cells, Cultured
Rats
Rats, Inbred Strains
Time Factors
Trachea

Source PubMed

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References12

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	6,036,174	Differentiation of receptor systems activated by sympathomimetic amines.	Nature	1967	https://conductscience.org/library/papers/6036174	PubMed
2	4,330,379	A simple and sensitive saturation assay method for the measurement of adenosine 3':5'-cyclic monophosphate.	Biochem J	1971	https://conductscience.org/library/papers/4330379	PubMed
3	165,678	Relationship between cyclic AMP metabolism and inotropic response of perfused rat hearts to phenylephrine and other adrenergic amines.	Adv Cyclic Nucleotide Res	1975	https://conductscience.org/library/papers/165678	PubMed
4	168,352	Changes in mechanical events and adenosine 3',5'-monophosphate levels induced by enantiomers of isoproterenol in isolated rat atria and uteri.	J Pharmacol Exp Ther	1975	https://conductscience.org/library/papers/168352	PubMed
5	24,540	Studies on beta-adrenoceptors mediating changes in mechanical events and adenosine 3',5'-monophosphate levels. Rat atria.	Eur J Pharmacol	1978	https://conductscience.org/library/papers/24540	PubMed
6	39,243	The pharmacological specificity of beta-1 and beta-2 adrenergic receptors in rat heart and lung in vitro.	Mol Pharmacol	1979	https://conductscience.org/library/papers/39243	PubMed
7	13,952,710	In vitro studies on single beating rat heart cells. I. Growth and organization.	Exp Cell Res	1963	https://conductscience.org/library/papers/13952710	PubMed
8	6,244,386	Differential distribution of beta-1 and beta-2 adrenergic receptors in cat and guinea-pig heart.	J Pharmacol Exp Ther	1980	https://conductscience.org/library/papers/6244386	PubMed
9	6,104,287	Beta1- and beta2-adrenergic receptors responsible for cyclic AMP accumulation in isolated heart and lung cells.	Mol Pharmacol	1980	https://conductscience.org/library/papers/6104287	PubMed
10	6,121,296	Cardiostimulatory effects of prenalterol, a beta-1 adrenoceptor partial agonist, in vivo and in vitro. Correlation between physiological effects and adenylate cyclase activity.	Naunyn Schmiedebergs Arch Pharmacol	1982	https://conductscience.org/library/papers/6121296	PubMed
11	6,121,868	Effects of N-aralkyl substitution of beta-agonists on alpha- and beta-adrenoceptor subtypes: pharmacological studies and binding assays.	J Pharm Pharmacol	1982	https://conductscience.org/library/papers/6121868	PubMed
13	41,190	The importance of choice of agonist in studies designed to predict beta 2 : beta 1 adrenoceptor selectivity of antagonists from pA2 values on guinea-pig trachea and atria.	Naunyn Schmiedebergs Arch Pharmacol	1979	https://conductscience.org/library/papers/41190	PubMed

Show 6 more referencesShow fewer references

Cited by6

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 22 citations.

PMID	Title	Journal	Year	In Papers	Source
32,411,580	Effects of β2-adrenergic agonists on house dust mite-induced adhesion, superoxide anion generation, and degranulation of human eosinophils.	Asia Pac Allergy	2020	https://conductscience.org/library/papers/32411580	PubMed
25,432,985	PDE2 activity differs in right and left rat ventricular myocardium and differentially regulates β2 adrenoceptor-mediated effects.	Exp Biol Med (Maywood)	2015	https://conductscience.org/library/papers/25432985	PubMed
8,032,618	Evidence for a cooperation between adenosine A2 receptors and beta 1-adrenoceptors on cardiac automaticity in the isolated right ventricle of the rat.	Br J Pharmacol	1994	https://conductscience.org/library/papers/8032618	PubMed
2,875,397	Beta-adrenoceptor antagonists (non-selective as well as beta 1-selective) with partial agonistic activity decrease beta 2-adrenoceptor density in human lymphocytes. Evidence for a beta 2-agonistic component of the partial agonistic activity.	Naunyn Schmiedebergs Arch Pharmacol	1986	https://conductscience.org/library/papers/2875397	PubMed
2,865,685	Beta 1- and beta 2-adrenoceptor binding and functional response in right and left atria of rat heart.	Naunyn Schmiedebergs Arch Pharmacol	1985	https://conductscience.org/library/papers/2865685	PubMed
1,718,682	Formoterol. A review of its pharmacological properties and therapeutic potential in reversible obstructive airways disease.	Drugs	1991	https://conductscience.org/library/papers/1718682	PubMed

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

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ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

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ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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