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Paper · 578705

Irreversible binding of 14C-labelled trichloroethylene to mice liver constituents in vivo and in vitro.

Uehleke H and 1 other. Arch Toxicol, 1977. Cited by 41 papers, by iCite.

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ConductScience Library. Irreversible binding of 14C-labelled trichloroethylene to mice liver constituents in vivo and in vitro. Papers, record 578705. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/578705

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Irreversible binding of 14C-labelled trichloroethylene to mice liver constituents in vivo and in vitro.
PubMed
Journal
Arch Toxicol
PubMed
Year
1977
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
41
iCite
Relative citation ratio, by iCite
2.14
iCite
Revised in PubMed
2026-10-10
PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Uehleke HH
2Poplawski-Tabarelli SS

Source PubMed

Topics9

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Carbon RadioisotopesMajor topic
LiverMajor topic
TrichloroethyleneMajor topic
Animals
Lipid Metabolism
Mice
Mice, Inbred Strains
Microsomes, Liver
Protein Binding

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References14

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
14,147,966Metabolic activation of halothane and its covalent binding to liver endoplasmic proteins in vitro.Naunyn Schmiedebergs Arch Pharmacol1973https://conductscience.org/library/papers/4147966PubMed
24,144,825Binding of 14 C-carbon tetrachloride to microsomal proteins in vitro and formation of CHC1 3 by reduced liver microsomes.Xenobiotica1973https://conductscience.org/library/papers/4144825PubMed
3791,581Chemical reactivity, biotransformation, and toxicity of polychlorinated aliphatic compounds.CRC Crit Rev Toxicol1976https://conductscience.org/library/papers/791581PubMed
414,071,536THE METABOLISM OF 36C1-LABELLED TRICHLOROETHYLENE AND TETRACHLOROETHYLENE IN THE RAT.Biochem Pharmacol1963https://conductscience.org/library/papers/14071536PubMed
5329,590Metabolic activation of haloalkanes and tests in vitro for mutagenicity.Xenobiotica1977https://conductscience.org/library/papers/329590PubMed
64,363,358Enhancement of the hepatotoxicity of trichloroethylene by inducers of drug metabolism.Res Commun Chem Pathol Pharmacol1974https://conductscience.org/library/papers/4363358PubMed
74,357,489Carbon tetrachloride hepatotoxicity: an example of lethal cleavage.CRC Crit Rev Toxicol1973https://conductscience.org/library/papers/4357489PubMed
83,152A comparative study on the irreversible binding of labeled halothane trichlorofluoromethane, chloroform, and carbon tetrachloride to hepatic protein and lipids in vitro and in vivo.Arch Toxicol1975https://conductscience.org/library/papers/3152PubMed
91,277,148Covalent interaction of metabolites of the carcinogen trichloroethylene in rat hepatic microsomes.Cancer Res1976https://conductscience.org/library/papers/1277148PubMed
105,098,347[Binding of carbon tetrachloride to reduced microsomal cytochrome P-450 and to heme].Hoppe Seylers Z Physiol Chem1971https://conductscience.org/library/papers/5098347PubMed

1 to 10 of 14

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Cited by12

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 41 citations.

PMIDTitleJournalYearIn PapersSource
21,432,291Regulatory heme and trichloroethylene intoxication: A possible explanation of the case of "A Civil Action".Environ Health Prev Med2002https://conductscience.org/library/papers/21432291PubMed
17,376,499Differential immune responses to albumin adducts of reactive intermediates of trichloroethene in MRL+/+ mice.Toxicol Appl Pharmacol2007https://conductscience.org/library/papers/17376499PubMed
16,348,039Toxicity of Trichloroethylene to Pseudomonas putida F1 Is Mediated by Toluene Dioxygenase.Appl Environ Microbiol1989https://conductscience.org/library/papers/16348039PubMed
7,429,647The effect of trichloroethylene on some serum-enzymes, on the cytoenzymological activity in leucocytes, and on the acid-base equilibrium.Int Arch Occup Environ Health1980https://conductscience.org/library/papers/7429647PubMed
7,059,279Increased acetone exhalation induced by metabolites of halogenated C1 and C2 compounds.Arch Toxicol1982https://conductscience.org/library/papers/7059279PubMed
6,893,145Trichloroethylene vapours do not produce dominant lethal mutations in male mice.Arch Toxicol1980https://conductscience.org/library/papers/6893145PubMed
6,830,310Human environmental exposure to trichloro- and tetrachloroethylene from water and air in Milan, Italy.Arch Environ Contam Toxicol1983https://conductscience.org/library/papers/6830310PubMed
6,197,950Interactions of trichloroethylene with DNA in vitro and with RNA and DNA of various mouse tissues in vivo.Arch Toxicol1983https://conductscience.org/library/papers/6197950PubMed
3,917,197Activities of chlorinated ethane and ethylene compounds in the Salmonella/rat microsome mutagenesis and rat hepatocyte/DNA repair assays under vapor phase exposure conditions.Cell Biol Toxicol1985https://conductscience.org/library/papers/3917197PubMed
2,036,023Kinetics of chlorinated hydrocarbon degradation by Methylosinus trichosporium OB3b and toxicity of trichloroethylene.Appl Environ Microbiol1991https://conductscience.org/library/papers/2036023PubMed

1 to 10 of 12

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Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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