Paper · 3152
A comparative study on the irreversible binding of labeled halothane trichlorofluoromethane, chloroform, and carbon tetrachloride to hepatic protein and lipids in vitro and in vivo.
Uehleke H and 1 other. Arch Toxicol, 1975. Cited by 70 papers, by iCite.
11 sourcespapers-2026-11-12-0.1.0
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ConductScience Library. A comparative study on the irreversible binding of labeled halothane trichlorofluoromethane, chloroform, and carbon tetrachloride to hepatic protein and lipids in vitro and in vivo. Papers, record 3152. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/3152
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Paper
PubMed's record of the paper, with iCite's citation figures. No abstract is shown.
- Title
- A comparative study on the irreversible binding of labeled halothane trichlorofluoromethane, chloroform, and carbon tetrachloride to hepatic protein and lipids in vitro and in vivo.
- PubMed
Topics25
NLM's MeSH indexing of the paper, its major topics first.
| MeSH term | Major |
|---|---|
| Carbon Tetrachloride | Major topic |
| Chloroform | Major topic |
| Halothane | Major topic |
| Liver | Major topic |
| 1-Propanol | |
| Aerobiosis | |
| Age Factors | |
| Anaerobiosis | |
| Animals | |
| Cobalt | |
| Cytochrome P-450 Enzyme System | |
| Endoplasmic Reticulum | |
| Humans | |
| In Vitro Techniques | |
| Lipid Metabolism | |
| Methylcholanthrene | |
| Mice | |
| Microsomes, Liver | |
| Mitochondria, Liver | |
| NADP | |
| Phenobarbital | |
| Protein Binding | |
| Rabbits | |
| Rats | |
| Species Specificity |
Source PubMed
Grants0
Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.
None in this release.
Trials0
The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.
None in this release.
Comments and corrections0
PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.
None in this release.
References53
The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.
| Order | PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|---|
| 1 | 4,147,966 | Metabolic activation of halothane and its covalent binding to liver endoplasmic proteins in vitro. | Naunyn Schmiedebergs Arch Pharmacol | 1973 | https://conductscience.org/library/papers/4147966 | PubMed |
| 2 | 4,145,288 | Binding of radioactivity from 14 C-labeled halothane in isolated perfused rat livers. | Anesthesiology | 1973 | https://conductscience.org/library/papers/4145288 | PubMed |
| 3 | 4,404,917 | [Formation of chloroform from carbon tetrachloride in liver microsomes, lipid peroxidation and destruction of cytochrome P-450]. | Arch Toxikol | 1972 | https://conductscience.org/library/papers/4404917 | PubMed |
| 4 | 4,283,696 | The role of metabolism in chloroform hepatotoxicity. | Toxicol Appl Pharmacol | 1974 | https://conductscience.org/library/papers/4283696 | PubMed |
| 5 | 4,686,098 | The absence of effect of phenobarbital on halothane toxicity. | Res Commun Chem Pathol Pharmacol | 1973 | https://conductscience.org/library/papers/4686098 | PubMed |
| 6 | 4,405,141 | Enhanced hepatic microsomal activity by pretreatment of rats with acetone or isopropanol. | Proc Soc Exp Biol Med | 1973 | https://conductscience.org/library/papers/4405141 | PubMed |
| 7 | 4,721,720 | Further observation on the effects of 3-methylcholanthrene and phenobarbital on carbon tetrachloride hepatotoxicity. | Exp Mol Pathol | 1973 | https://conductscience.org/library/papers/4721720 | PubMed |
| 8 | 14,025,587 | Carbon tetrachloride poisoning in the liver of the new-born rat. | J Pathol Bacteriol | 1963 | https://conductscience.org/library/papers/14025587 | PubMed |
| 9 | 4,149,397 | The role of cytochrome P-450 in the N-oxidation of individual amines. | Drug Metab Dispos | 1973 | https://conductscience.org/library/papers/4149397 | PubMed |
| 10 | 14,245,252 | THE CONVERSION OF CARBON TETRACHLORIDE AND CHLOROFORM TO CARBON DIOXIDE BY RAT LIVER HOMOGENATES. | Can J Biochem | 1964 | https://conductscience.org/library/papers/14245252 | PubMed |
1 to 10 of 53
See all 53 referencesCited by8
The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 70 citations.
| PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|
| 7,059,279 | Increased acetone exhalation induced by metabolites of halogenated C1 and C2 compounds. | Arch Toxicol | 1982 | https://conductscience.org/library/papers/7059279 | PubMed |
| 7,035,210 | Toxic drug effects associated with oxygen metabolism: redox cycling and lipid peroxidation. | Experientia | 1981 | https://conductscience.org/library/papers/7035210 | PubMed |
| 6,156,044 | Antigens of the human liver. | Clin Exp Immunol | 1980 | https://conductscience.org/library/papers/6156044 | PubMed |
| 3,816,736 | Enhancement of the hepatotoxicity of chloroform in B6C3F1 mice by corn oil: implications for chloroform carcinogenesis. | Environ Health Perspect | 1986 | https://conductscience.org/library/papers/3816736 | PubMed |
| 3,007,102 | Biochemical studies on the metabolic activation of halogenated alkanes. | Environ Health Perspect | 1985 | https://conductscience.org/library/papers/3007102 | PubMed |
| 612,434 | Irreversible binding of chlorinated ethylenes to macromolecules. | Environ Health Perspect | 1977 | https://conductscience.org/library/papers/612434 | PubMed |
| 578,705 | Irreversible binding of 14C-labelled trichloroethylene to mice liver constituents in vivo and in vitro. | Arch Toxicol | 1977 | https://conductscience.org/library/papers/578705 | PubMed |
| 18,130 | Spectral evidence for 2,2,3-trichloro-oxirane formation during microsomal trichloroethylene oxidation. | Arch Toxicol | 1977 | https://conductscience.org/library/papers/18130 | PubMed |
Genes0
The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.
None in this release.
Drugs0
The drugs whose trials, in the Pipelines release, list the paper.
None in this release.
Data0
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None in this release.
Data dates
The date of each source this release read.
- Trials
- 2026-11-12
- Gene search
- 2026-11-11
- Pipelines
- 2026-09-18
Sources 11
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- HGNCCC0
- iCiteCC BY 4.0
- NCBI GenePublic domain (US government)
- NIH RePORTER's grant and paper linksPublic domain
- Open TargetsCC0 1.0
- PMC's ID filePublic domain (US government)
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- HGNCCC0: https://www.genenames.org/about/license/
- iCiteCC BY 4.0
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
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