Paper · 6148751

Intrinsic GTPase activity distinguishes normal and oncogenic ras p21 molecules.

Gibbs JB and 3 others. Proc Natl Acad Sci U S A, 1984. Cited by 626 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Intrinsic GTPase activity distinguishes normal and oncogenic ras p21 molecules. Papers, record 6148751. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/6148751

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Intrinsic GTPase activity distinguishes normal and oncogenic ras p21 molecules.; PubMed
Journal: Proc Natl Acad Sci U S A; PubMed
Year: 1984; PubMed
Publication types: Comparative Study, Journal Article; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/6148751/; PubMed
DOI: https://doi.org/10.1073/pnas.81.18.5704; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC391779/; PubMed
The journal: https://conductscience.org/library/journal-index/7505876; PubMed
Citations, by iCite: 626; iCite
Relative citation ratio, by iCite: 11.3; iCite
Revised in PubMed: 2019-05-01; PubMed

Authors4

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Gibbs JB	J B
2	Sigal IS	I S
3	Poe M	M
4	Scolnick EM	E M

Source PubMed

Topics14

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
GTP Phosphohydrolases	Major topic
Neoplasm Proteins	Major topic
Oncogenes	Major topic
Phosphoric Monoester Hydrolases	Major topic
Animals
Escherichia coli
Genetic Vectors
Mice
Mutation
Phosphorus Radioisotopes
Phosphorylation
Plasmids
Protein Binding
Proto-Oncogene Proteins p21(ras)

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References27

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	4,941,237	Protein biosynthesis.	Annu Rev Biochem	1971	https://conductscience.org/library/papers/4941237	PubMed
2	228,288	Guanine nucleotide-binding activity as an assay for src protein of rat-derived murine sarcoma viruses.	Proc Natl Acad Sci U S A	1979	https://conductscience.org/library/papers/228288	PubMed
3	232,214	Plasmids of Escherichia coli as cloning vectors.	Methods Enzymol	1979	https://conductscience.org/library/papers/232214	PubMed
4	6,247,068	Localization of the src gene product of the Harvey strain of MSV to plasma membrane of transformed cells by electron microscopic immunocytochemistry.	Cell	1980	https://conductscience.org/library/papers/6247068	PubMed
5	6,104,671	The coupling with polypeptide synthesis of the GTPase activity dependent on elongation factor G.	J Biol Chem	1980	https://conductscience.org/library/papers/6104671	PubMed
6	6,253,810	Guanine nucleotide-binding and autophosphorylating activities associated with the p21src protein of Harvey murine sarcoma virus.	Nature	1980	https://conductscience.org/library/papers/6253810	PubMed
7	6,267,583	Analysis of two divergent rat genomic clones homologous to the transforming gene of Harvey murine sarcoma virus.	Proc Natl Acad Sci U S A	1981	https://conductscience.org/library/papers/6267583	PubMed
8	7,037,779	Hydrolysis of GTP by elongation factor Tu can be induced by monovalent cations in the absence of other effectors.	J Biol Chem	1982	https://conductscience.org/library/papers/7037779	PubMed
9	7,074,077	Assembly of microtubule protein: role of guanosine di- and triphosphate nucleotides.	Biochemistry	1982	https://conductscience.org/library/papers/7074077	PubMed
10	6,283,358	Tumorigenic transformation of mammalian cells induced by a normal human gene homologous to the oncogene of Harvey murine sarcoma virus.	Nature	1982	https://conductscience.org/library/papers/6283358	PubMed

1 to 10 of 27

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Cited by206

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 626 citations.

PMID	Title	Journal	Year	In Papers	Source
41,756,324	Lung adenocarcinoma with KRAS-Q61H: clinicopathologic features, diagnostics, and the evolving treatment landscape.	Front Oncol	2026	https://conductscience.org/library/papers/41756324	PubMed
41,750,275	Generation of Human Haematopoietic Model Cell Lines Revealed Distinct Replication Stress Tolerance Between Two Oncogenic KRAS Mutations, G12V and A146T.	Biomolecules	2026	https://conductscience.org/library/papers/41750275	PubMed
41,598,808	KRAS Inhibition in Pancreatic Ductal Adenocarcinoma.	J Clin Med	2026	https://conductscience.org/library/papers/41598808	PubMed
41,158,876	ARF: the most misunderstood GTPase I ever knew - why study ARF GAPs.	Front Mol Biosci	2025	https://conductscience.org/library/papers/41158876	PubMed
40,930,400	Michaelis-Menten kinetics of RasGAP proteins by a rapid fluorescence-based assay.	Methods	2025	https://conductscience.org/library/papers/40930400	PubMed
39,638,567	"Undruggable KRAS": druggable after all.	Genes Dev	2025	https://conductscience.org/library/papers/39638567	PubMed
39,537,865	VP28 interacts with PmRab7 irrespective of its nucleotide state.	Sci Rep	2024	https://conductscience.org/library/papers/39537865	PubMed
39,404,173	Advances and Challenges in RAS Signaling Targeted Therapy in Leukemia.	Mol Cancer Ther	2025	https://conductscience.org/library/papers/39404173	PubMed
39,164,274	MYC and KRAS cooperation: from historical challenges to therapeutic opportunities in cancer.	Signal Transduct Target Ther	2024	https://conductscience.org/library/papers/39164274	PubMed
38,570,448	Progress in Targeting KRAS Directly.	Methods Mol Biol	2024	https://conductscience.org/library/papers/38570448	PubMed

1 to 10 of 206

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Genes1

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes
H3P16	644,914	PubTator's text mining	https://conductscience.org/library/genes/644914

Source NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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