Paper · 6283358

Tumorigenic transformation of mammalian cells induced by a normal human gene homologous to the oncogene of Harvey murine sarcoma virus.

Chang EH and 3 others. Nature, 1982. Cited by 603 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Tumorigenic transformation of mammalian cells induced by a normal human gene homologous to the oncogene of Harvey murine sarcoma virus. Papers, record 6283358. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/6283358

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Tumorigenic transformation of mammalian cells induced by a normal human gene homologous to the oncogene of Harvey murine sarcoma virus.; PubMed
Journal: Nature; PubMed
Year: 1982; PubMed
Publication types: Journal Article, Research Support, U.S. Gov't, P.H.S.; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/6283358/; PubMed
DOI: https://doi.org/10.1038/297479a0; PubMed
The journal: https://conductscience.org/library/journal-index/0410462; PubMed
Citations, by iCite: 603; iCite
Relative citation ratio, by iCite: 12.3; iCite
Revised in PubMed: 2022-02-25; PubMed

Authors4

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Chang EH	E H
2	Furth ME	M E
3	Scolnick EM	E M
4	Lowy DR	D R

Source PubMed

Topics15

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Cell Transformation, Neoplastic	Major topic
Genes	Major topic
Genes, Viral	Major topic
Sarcoma Viruses, Murine	Major topic
Animals
Cell Line
Cells, Cultured
DNA Restriction Enzymes
DNA, Recombinant
Humans
Kirsten murine sarcoma virus
Mice
Nucleic Acid Hybridization
Rats
Species Specificity

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References0

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

None in this release.

Cited by164

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 603 citations.

PMID	Title	Journal	Year	In Papers	Source
41,229,267	A novel carcinogenic mouse model by site-directed insertion of tandem human HRAS large DNA fragment into 15E1 site.	Animal Model Exp Med	2025	https://conductscience.org/library/papers/41229267	PubMed
40,268,809	Efficacy of CRISPR-Cas9 gene editing for targeting KRAS mutations in pancreatic cancer: a systematic review.	Discov Oncol	2025	https://conductscience.org/library/papers/40268809	PubMed
39,367,162	KRAS mutations detection methodology: from RFLP to CRISPR/Cas based methods.	Funct Integr Genomics	2024	https://conductscience.org/library/papers/39367162	PubMed
37,964,407	Oncogenic KRAS, Mucin 4, and Activin A-Mediated Fibroblast Activation Cooperate for PanIN Initiation.	Adv Sci (Weinh)	2023	https://conductscience.org/library/papers/37964407	PubMed
36,077,614	DNA Polymerase Theta Plays a Critical Role in Pancreatic Cancer Development and Metastasis.	Cancers (Basel)	2022	https://conductscience.org/library/papers/36077614	PubMed
32,493,501	Prevention of tumor risk associated with the reprogramming of human pluripotent stem cells.	J Exp Clin Cancer Res	2020	https://conductscience.org/library/papers/32493501	PubMed
27,340,238	Oncogenic KRAS and BRAF Drive Metabolic Reprogramming in Colorectal Cancer.	Mol Cell Proteomics	2016	https://conductscience.org/library/papers/27340238	PubMed
26,284,568	MicroRNA-Based Therapeutic Strategies for Targeting Mutant and Wild Type RAS in Cancer.	Drug Dev Res	2015	https://conductscience.org/library/papers/26284568	PubMed
26,070,366	Combined HSP90 and kinase inhibitor therapy: Insights from The Cancer Genome Atlas.	Cell Stress Chaperones	2015	https://conductscience.org/library/papers/26070366	PubMed
25,621,172	Putting the pieces together: How is the mitochondrial pathway of apoptosis regulated in cancer and chemotherapy?	Cancer Metab	2014	https://conductscience.org/library/papers/25621172	PubMed

1 to 10 of 164

See all 164 cited by

Genes1

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes
HRAS	3,265	PubTator's text mining	https://conductscience.org/library/genes/3265

Source NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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