Paper · 6180304

Single-copy and amplified CAD genes in Syrian hamster chromosomes localized by a highly sensitive method for in situ hybridization.

Wahl GM and 3 others. Mol Cell Biol, 1982. Cited by 87 papers, by iCite.

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ConductScience Library. Single-copy and amplified CAD genes in Syrian hamster chromosomes localized by a highly sensitive method for in situ hybridization. Papers, record 6180304. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/6180304

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Single-copy and amplified CAD genes in Syrian hamster chromosomes localized by a highly sensitive method for in situ hybridization.; PubMed
Journal: Mol Cell Biol; PubMed
Year: 1982; PubMed
Publication types: Journal Article, Research Support, U.S. Gov't, P.H.S.; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/6180304/; PubMed
DOI: https://doi.org/10.1128/mcb.2.3.308-319.1982; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC369790/; PubMed
The journal: https://conductscience.org/library/journal-index/8109087; PubMed
Citations, by iCite: 87; iCite
Relative citation ratio, by iCite: 1.94; iCite
Revised in PubMed: 2021-05-26; PubMed

Authors4

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Wahl GM	G M
2	Vitto L	L
3	Padgett RA	R A
4	Stark GR	G R

Source PubMed

Topics18

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Chromosome Mapping	Major topic
Multienzyme Complexes	Major topic
Nucleic Acid Hybridization	Major topic
Animals
Aspartic Acid
Cells, Cultured
Chromosome Aberrations
Cricetinae
DNA
DNA, Recombinant
Dextran Sulfate
Dextrans
Drug Resistance
Gene Amplification
Karyotyping
Kidney
Mesocricetus
Phosphonoacetic Acid

Source PubMed

Grants3

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes it	Agency	Country	NIH project	Stated by	Source
5T016M196	PHS HHS	United States		PubMed	PubMed
CA-17287	NCI NIH HHS	United States	R01CA017287	PubMed and NIH	NIH RePORTER
GM-27754	NIGMS NIH HHS	United States	R01GM027754	PubMed and NIH	NIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References35

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	5,963,888	A membrane-filter technique for the detection of complementary DNA.	Biochem Biophys Res Commun	1966	https://conductscience.org/library/papers/5963888	PubMed
2	5,253,668	Hybridization of hamster cells with high and low folate reductase activity.	Proc Natl Acad Sci U S A	1969	https://conductscience.org/library/papers/5253668	PubMed
3	4,107,917	A rapid banding technique for human chromosomes.	Lancet	1971	https://conductscience.org/library/papers/4107917	PubMed
4	4,402,276	Two different species of dihydrofolate reductase in mammalian cells differentially resistant to amethopterin and methasquin.	Cancer Res	1972	https://conductscience.org/library/papers/4402276	PubMed
5	4,121,202	Identification of Syrian hamster chromosomes by acetic-saline-Giemsa (ASG) and trypsin techniques.	Cytogenetics	1972	https://conductscience.org/library/papers/4121202	PubMed
6	4,371,054	N-(phosphonacetyl)-L-aspartate, a potent transition state analog inhibitor of aspartate transcarbamylase, blocks proliferation of mammalian cells in culture.	J Biol Chem	1974	https://conductscience.org/library/papers/4371054	PubMed
7	942,798	Metaphase chromosome anomaly: association with drug resistance and cell-specific products.	Science	1976	https://conductscience.org/library/papers/942798	PubMed
8	975,935	Location of nucleolar organizing regions on the chromosomes of the Syrian hamster (Mesocricetus auratus) and the Djungarian hamster (Phodopus sungorus).	Cytogenet Cell Genet	1976	https://conductscience.org/library/papers/975935	PubMed
9	12,870	Stable mutants of mammalian cells that overproduce the first three enzymes of pyrimidine nucleotide biosynthesis.	Cell	1976	https://conductscience.org/library/papers/12870	PubMed
10	1,028,172	Isolation and partial characterization of three methotrexate-resistant phenotypes from Chinese hamster ovary cells.	Somatic Cell Genet	1976	https://conductscience.org/library/papers/1028172	PubMed

1 to 10 of 35

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Cited by39

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 87 citations.

PMID	Title	Journal	Year	In Papers	Source
22,358,436	Localization of amplified CAD genes on rearranged chromosomes of Chinese hamster cells.	Cytotechnology	1987	https://conductscience.org/library/papers/22358436	PubMed
19,002,887	Identification of transgene integration loci of different highly expressing recombinant CHO cell lines by FISH.	Cytotechnology	2006	https://conductscience.org/library/papers/19002887	PubMed
10,938,367	Fluoroorotic acid-selected Nicotiana plumbaginifolia cell lines with a stable thymine starvation phenotype have lost the thymine-regulated transcriptional program.	Plant Physiol	2000	https://conductscience.org/library/papers/10938367	PubMed
8,202,521	MYCN is retained in single copy at chromosome 2 band p23-24 during amplification in human neuroblastoma cells.	Proc Natl Acad Sci U S A	1994	https://conductscience.org/library/papers/8202521	PubMed
7,623,808	Identification of an origin of bidirectional DNA replication in the ubiquitously expressed mammalian CAD gene.	Mol Cell Biol	1995	https://conductscience.org/library/papers/7623808	PubMed
6,961,456	Two human c-onc genes are located on the long arm of chromosome 8.	Proc Natl Acad Sci U S A	1982	https://conductscience.org/library/papers/6961456	PubMed
6,896,736	General method for cloning amplified DNA by differential screening with genomic probes.	Mol Cell Biol	1982	https://conductscience.org/library/papers/6896736	PubMed
6,855,772	Evolution of chromosomal regions containing transfected and amplified dihydrofolate reductase sequences.	Mol Cell Biol	1983	https://conductscience.org/library/papers/6855772	PubMed
6,656,764	Properties of single-step mutants of Syrian hamster cell lines resistant to N-(phosphonacetyl)-L-aspartate.	Mol Cell Biol	1983	https://conductscience.org/library/papers/6656764	PubMed
6,656,763	Structure of amplified DNA in different Syrian hamster cell lines resistant to N-(phosphonacetyl)-L-aspartate.	Mol Cell Biol	1983	https://conductscience.org/library/papers/6656763	PubMed

1 to 10 of 39

See all 39 cited by

Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

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ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

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ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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