Paper · 12870

Stable mutants of mammalian cells that overproduce the first three enzymes of pyrimidine nucleotide biosynthesis.

Kempe TD and 3 others. Cell, 1976. Cited by 223 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

Cite this record

ConductScience Library. Stable mutants of mammalian cells that overproduce the first three enzymes of pyrimidine nucleotide biosynthesis. Papers, record 12870. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/12870

On this page

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Stable mutants of mammalian cells that overproduce the first three enzymes of pyrimidine nucleotide biosynthesis.; PubMed
Journal: Cell; PubMed
Year: 1976; PubMed
Publication types: Journal Article; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/12870/; PubMed
DOI: https://doi.org/10.1016/0092-8674(76)90036-2; PubMed
The journal: https://conductscience.org/library/journal-index/0413066; PubMed
Citations, by iCite: 223; iCite
Relative citation ratio, by iCite: 5.52; iCite
Revised in PubMed: 2019-07-05; PubMed

Authors4

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Kempe TD	T D
2	Swyryd EA	E A
3	Bruist M	M
4	Stark GR	G R

Source PubMed

Topics18

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Amidohydrolases	Major topic
Aspartate Carbamoyltransferase	Major topic
Aspartic Acid	Major topic
Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing)	Major topic
Dihydroorotase	Major topic
Genes	Major topic
Organophosphorus Compounds	Major topic
Phosphotransferases	Major topic
Pyrimidine Nucleotides	Major topic
Binding Sites
Cell Division
Cell Line
Dihydroorotate Oxidase
Drug Resistance
Mutation
Neoplasms, Experimental
Orotate Phosphoribosyltransferase
Orotidine-5'-Phosphate Decarboxylase

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References0

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

None in this release.

Cited by52

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 223 citations.

PMID	Title	Journal	Year	In Papers	Source
35,310,840	Novel Highlight in Malarial Drug Discovery: Aspartate Transcarbamoylase.	Front Cell Infect Microbiol	2022	https://conductscience.org/library/papers/35310840	PubMed
34,288,185	Deciphering CAD: Structure and function of a mega-enzymatic pyrimidine factory in health and disease.	Protein Sci	2021	https://conductscience.org/library/papers/34288185	PubMed
28,304,928	Rudimentary mutants ofDrosophila melanogaster : Isolation and characterization of pyrimidine auxotrophic cell lines.	Wilehm Roux Arch Dev Biol	1979	https://conductscience.org/library/papers/28304928	PubMed
24,241,524	Detoxification of N-(phosphonoacetyl)-L-aspartate by carrot cells in suspension culture.	Planta	1985	https://conductscience.org/library/papers/24241524	PubMed
22,520,844	The JAK-STAT pathway at twenty.	Immunity	2012	https://conductscience.org/library/papers/22520844	PubMed
22,419,077	Gene overexpression: uses, mechanisms, and interpretation.	Genetics	2012	https://conductscience.org/library/papers/22419077	PubMed
22,358,436	Localization of amplified CAD genes on rearranged chromosomes of Chinese hamster cells.	Cytotechnology	1987	https://conductscience.org/library/papers/22358436	PubMed
17,206,380	Protein kinase A phosphorylation of the multifunctional protein CAD antagonizes activation by the MAP kinase cascade.	Mol Cell Biochem	2007	https://conductscience.org/library/papers/17206380	PubMed
12,370,813	Genomic instability driven by the human T-cell leukemia virus type I (HTLV-I) oncoprotein, Tax.	Oncogene	2002	https://conductscience.org/library/papers/12370813	PubMed
11,717,437	High rate of CAD gene amplification in human cells deficient in MLH1 or MSH6.	Proc Natl Acad Sci U S A	2001	https://conductscience.org/library/papers/11717437	PubMed

1 to 10 of 52

See all 52 cited by

Genes2

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes	Source
DHODH	1,723	PubTator's text mining	https://conductscience.org/library/genes/1723	NCBI Gene
UMPS	7,372	PubTator's text mining	https://conductscience.org/library/genes/7372	NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this paper from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/papers/v1/12870

GET https://conductscience.org/api/papers/v1/12870/cited_by?page=2

API reference For AI assistants