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Gene · 1723

DHODH: dihydroorotate dehydrogenase (quinone)

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. DHODH: dihydroorotate dehydrogenase (quinone). Genes, record 1723. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1723

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Gene

Symbol
DHODH
HGNC
Name
dihydroorotate dehydrogenase (quinone)
HGNC
NCBI Gene ID
1723
NCBI Gene
HGNC ID
HGNC:2867
HGNC
Ensembl
ENSG00000102967
NCBI Gene
Aliases
DHOdehase, POADS, URA1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q02127Dihydroorotate dehydrogenase (quinone), mitochondrial395105Ensembl, GeneID, HGNC

Source UniProt

Patents36

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1443785Q02127Espacenet
JP 2025529142 A2025-09-041256Q02127Espacenet
US 12371689 B22025-07-291256Q02127Espacenet
EP 4541812 A22025-04-234Q02127Espacenet
US 12203103 B22025-01-214Q02127Espacenet
JP 2023544267 A2023-10-2332Q02127Espacenet
KR 1020230068401 A2023-05-174Q02127Espacenet
US 11446398 B22022-09-2024389Q02127Espacenet
US 11400116 B22022-08-022351Q02127Espacenet
US 11401555 B22022-08-02100Q02127Espacenet

1 to 10 of 36

See all 36 patents

Drugs6

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ASLAN-003CHEMBL2263632Dihydroorotate dehydrogenase inhibitorINHIBITORChEMBL
BREQUINARCHEMBL38434Dihydroorotate dehydrogenase inhibitorINHIBITORChEMBL
EMVODODSTATCHEMBL4650336Dihydroorotate dehydrogenase inhibitorINHIBITORChEMBL
LEFLUNOMIDECHEMBL960Dihydroorotate dehydrogenase inhibitorINHIBITORChEMBL
TERIFLUNOMIDECHEMBL973Dihydroorotate dehydrogenase inhibitorINHIBITORChEMBL
VIDOFLUDIMUSCHEMBL197194Dihydroorotate dehydrogenase inhibitorINHIBITORChEMBL

Trials132

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07388407LEFLUNOMIDEClinicalTrials.gov
NCT07388407TERIFLUNOMIDEClinicalTrials.gov
NCT07189325TERIFLUNOMIDEPHASE3ClinicalTrials.gov
NCT06923488LEFLUNOMIDEPHASE1/PHASE2ClinicalTrials.gov
NCT06540937LEFLUNOMIDEPHASE2ClinicalTrials.gov
NCT06454383LEFLUNOMIDEPHASE1ClinicalTrials.gov
NCT06229340LEFLUNOMIDEPHASE2ClinicalTrials.gov
NCT06190145TERIFLUNOMIDEPHASE2ClinicalTrials.gov
NCT06176911TERIFLUNOMIDEPHASE2ClinicalTrials.gov
NCT06141473TERIFLUNOMIDEPHASE3ClinicalTrials.gov

1 to 10 of 132

See all 132 trials

NIH grants1,473

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleDHODH papersNewest fiscal year
R01AI103947Lead Optimization of DHODH Inhibitors for Malaria162025
P30CA008748Cancer Center Support Grant122025
P30CA016672Cancer Center Support Grant122025
R01AI109023Defining P. falciparum resistance to artemisinin-based combination therapies102025
P01CA120964Molecular Pathogenesis of the Hamartoma Syndromes72025
R01AI124678Elucidating the molecular basis of piperaquine resistance in Plasmodium falciparum72025
P30CA006516Dana-Farber/Harvard Cancer Center62025
R01AI028398Mitochondrial Functions in Malaria Parasites62025
R37AI050234Defining the Role of PfCRT and PfMDR1 as Pleiotropic Mediators of Plasmodium falciparum Multidrug Resistance62025
P30CA014051Cancer Center Support (Core) Grant52025

1 to 10 of 1,473Source NIH's project files

See all 1,473 nih grants

Papers2,016

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Development of High-Efficiency Mitochondrial Protease Targeting Chimeras (MtPTACs) for Targeted Degradation of POLRMT and Beyond.JACS Au202642819300PubTator, text miningPubMed
Structural insights into DHODH-mediated catalysis and drug resistance.bioRxiv202642818329PubTator, text miningPubMed
NRF2-Regulated Ferroptosis in Breast Cancer: Mechanisms, Resistance, and Therapeutic Opportunities.Asia Pac J Clin Oncol202642802387PubTator, text miningPubMed
Pharmacological targeting of ferroptosis in cancer: mechanisms, tumor immunity, and translational challenges.Pharmacol Rep202642789241PubTator, text miningPubMed
Programmed cell death evasion in BRAF V600E-driven primary CNS tumors and thyroid cancer brain metastases.Front Neurol202642769885PubTator, text miningPubMed
DHODH inhibition drives albumin-mediated drug resistance through TERF2IP lactylation-activated macropinosome-mitochondria contact.Nat Commun202642736281PubTator, text miningPubMed
Therapeutic Co-targeting of oxidative phosphorylation and pyrimidine synthesis restores gemcitabine response in pancreatic ductal adenocarcinoma.Transl Res202642732873PubTator, text miningPubMed
The redox paradox in neurological disorders: balancing cytoprotection, ferroptosis, and therapeutic targeting.Brain Res202642700879PubTator, text miningPubMed
Lysyl oxidase inhibition disrupts mitochondrial homeostasis to create vulnerability to ferroptosis in TNBC.Cell Rep Med202642673947PubTator, text miningPubMed
Network pharmacology based identification of potential phytocompounds from Betula utilis in the treatment of leishmaniasis.J Parasit Dis202642670328PubTator, text miningPubMed

1 to 10 of 2,016

See all 2,016 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/1723

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