Paper · 62055

A novel chromosome abnormality in human neuroblastoma and antifolate-resistant Chinese hamster cell lives in culture.

Biedler JL and 1 other. J Natl Cancer Inst, 1976. Cited by 209 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. A novel chromosome abnormality in human neuroblastoma and antifolate-resistant Chinese hamster cell lives in culture. Papers, record 62055. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/62055

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: A novel chromosome abnormality in human neuroblastoma and antifolate-resistant Chinese hamster cell lives in culture.; PubMed
Journal: J Natl Cancer Inst; PubMed
Year: 1976; PubMed
Publication types: Journal Article, Research Support, U.S. Gov't, P.H.S.; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/62055/; PubMed
DOI: https://doi.org/10.1093/jnci/57.3.683; PubMed
The journal: https://conductscience.org/library/journal-index/7503089; PubMed
Citations, by iCite: 209; iCite
Relative citation ratio, by iCite: 4.26; iCite
Revised in PubMed: 2019-05-09; PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	Kind	ORCID iD
1	Biedler JL	J L
2	Spengler BA	B A

Source PubMed

Topics15

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Chromosome Aberrations	Major topic
Folic Acid Antagonists	Major topic
Neuroblastoma	Major topic
Animals
Autoradiography
Azure Stains
Cell Line
Cells, Cultured
Cricetinae
DNA Replication
Drug Resistance
Humans
Neoplasms, Experimental
Staining and Labeling
Tetrahydrofolate Dehydrogenase

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References0

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

None in this release.

Cited by60

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 209 citations.

PMID	Title	Journal	Year	In Papers	Source
40,943,355	Ganglioside Profiling Uncovers Distinct Patterns in High-Risk Neuroblastoma.	Int J Mol Sci	2025	https://conductscience.org/library/papers/40943355	PubMed
40,823,512	Molecular cytogenetic study on the scleractinian coral Micromussaamakusensis (Veron, 1990) (Hexacorallia, Anthozoa, Cnidaria): isolation of five fluorescence in situ hybridization markers.	Comp Cytogenet	2025	https://conductscience.org/library/papers/40823512	PubMed
38,625,562	Imaging extrachromosomal DNA (ecDNA) in cancer.	Histochem Cell Biol	2024	https://conductscience.org/library/papers/38625562	PubMed
35,192,728	Poloxamer-linked prodrug of a topoisomerase I inhibitor SN22 shows efficacy in models of high-risk neuroblastoma with primary and acquired chemoresistance.	FASEB J	2022	https://conductscience.org/library/papers/35192728	PubMed
35,022,561	TWIST1 expression is associated with high-risk neuroblastoma and promotes primary and metastatic tumor growth.	Commun Biol	2022	https://conductscience.org/library/papers/35022561	PubMed
34,930,786	Plasticity of Extrachromosomal and Intrachromosomal BRAF Amplifications in Overcoming Targeted Therapy Dosage Challenges.	Cancer Discov	2022	https://conductscience.org/library/papers/34930786	PubMed
33,644,043	AQP1 Is Up-Regulated by Hypoxia and Leads to Increased Cell Water Permeability, Motility, and Migration in Neuroblastoma.	Front Cell Dev Biol	2021	https://conductscience.org/library/papers/33644043	PubMed
33,491,755	Effects of PI3K and FGFR inhibitors alone and in combination, and with/without cytostatics in childhood neuroblastoma cell lines.	Int J Oncol	2021	https://conductscience.org/library/papers/33491755	PubMed
31,776,131	Histone Lysine Methylation Dynamics Control EGFR DNA Copy-Number Amplification.	Cancer Discov	2020	https://conductscience.org/library/papers/31776131	PubMed
30,483,774	MYCN is amplified during S phase, and c‑myb is involved in controlling MYCN expression and amplification in MYCN‑amplified neuroblastoma cell lines.	Mol Med Rep	2019	https://conductscience.org/library/papers/30483774	PubMed

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Genes1

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes
DHFR	1,719	PubTator's text mining	https://conductscience.org/library/genes/1719

Source NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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