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Paper · 62818

Nature of the antigenic complex recognized by T lymphocytes. I. Analysis with an in vitro primary response to soluble protein antigens.

Thomas DW and 1 other. J Exp Med, 1976. Cited by 103 papers, by iCite.

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ConductScience Library. Nature of the antigenic complex recognized by T lymphocytes. I. Analysis with an in vitro primary response to soluble protein antigens. Papers, record 62818. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/62818

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Nature of the antigenic complex recognized by T lymphocytes. I. Analysis with an in vitro primary response to soluble protein antigens.
PubMed
Journal
J Exp Med
PubMed
Year
1976
PubMed
Publication types
Journal Article, Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
103
iCite
Relative citation ratio, by iCite
2.69
iCite
Revised in PubMed
2019-05-08
PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Thomas DWD W
2Shevach EME M

Source PubMed

Topics12

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
AntigensMajor topic
Lymphocyte ActivationMajor topic
MacrophagesMajor topic
T-LymphocytesMajor topic
Animals
Epitopes
Genes
Guinea Pigs
Isoantigens
Kinetics
Solubility
Structure-Activity Relationship

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References12

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
11,079,849The role of macrophages in the generation of T-helper cells. II. The genetic control of the macrophage-T-cell interaction for helper cell induction with soluble antigens.J Exp Med1975https://conductscience.org/library/papers/1079849PubMed
21,082,923Virus and trinitrophenol hapten-specific T-cell-mediated cytotoxicity against H-2 incompatible target cells.J Exp Med1976https://conductscience.org/library/papers/1082923PubMed
31,083,875The function of macrophages in antigen recognition by guinea pig T lymphocytes. III. Genetic analysis of the antigens mediating macrophage-T lymphocyte interaction.J Immunol1976https://conductscience.org/library/papers/1083875PubMed
41,084,997Role of major histocompatibility complex gene products in delayed-type hypersensitivity.Proc Natl Acad Sci U S A1976https://conductscience.org/library/papers/1084997PubMed
51,090,698Cell interactions between histoincompatible T and B lymphocytes. VII. Cooperative responses between lymphocytes are controlled by genes in the I region of the H-2 complex.J Exp Med1975https://conductscience.org/library/papers/1090698PubMed
6123,544Macrophage activation of allogeneic lymphocyte proliferation in the guinea pig mixed leukocyte culture.J Immunol1975https://conductscience.org/library/papers/123544PubMed
74,126,770Function of macrophages in antigen recognition by guinea pig T lymphocytes. II. Role of the macrophage in the regulation of genetic control of the immune response.J Exp Med1973https://conductscience.org/library/papers/4126770PubMed
84,542,806Function of macrophages in antigen recognition by guinea pig T lymphocytes. I. Requirement for histocompatible macrophages and lymphocytes.J Exp Med1973https://conductscience.org/library/papers/4542806PubMed
94,551,691Immune responses in vitro. I. Culture conditions for antibody synthesis.Cell Immunol1972https://conductscience.org/library/papers/4551691PubMed
1047,901
H-2 compatability requirement for T-cell-mediated lysis of target cells infected with lymphocytic choriomeningitis virus. Different cytotoxic T-cell specificities are associated with structures coded for in H-2K or H-2D;.
J Exp Med1975https://conductscience.org/library/papers/47901PubMed

1 to 10 of 12

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Cited by22

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 103 citations.

PMIDTitleJournalYearIn PapersSource
7,035,869Tuftsin, Thr-Lys-Pro-Arg. Anatomy of an immunologically active peptide.Mol Cell Biochem1981https://conductscience.org/library/papers/7035869PubMed
6,977,488HLA-DR antigens induce proliferation and cytotoxicity of T cells against haptenated (TNP and FITC) self structures.Immunogenetics1981https://conductscience.org/library/papers/6977488PubMed
6,974,758Antigen presentation to human T lymphocytes. I. Different requirements for stimulation by hapten-modified cells vs. cell sonicates.J Exp Med1981https://conductscience.org/library/papers/6974758PubMed
6,769,783The establishment of continuous macrophage cell lines from peripheal blood monocytes.Immunology1980https://conductscience.org/library/papers/6769783PubMed
6,768,830Role of I-region gene products in macrophage induction of an antibody response. II. Restriction at the level of T cell in recognition of I-J-subregion macrophage determinants.J Exp Med1980https://conductscience.org/library/papers/6768830PubMed
6,455,762T cell recognition of antigen in vivo: role of the H-2 complex.Springer Semin Immunopathol1980https://conductscience.org/library/papers/6455762PubMed
6,170,721Murine syngeneic mixed lymphocyte response. I. Target antigens are self Ia molecules.J Exp Med1981https://conductscience.org/library/papers/6170721PubMed
6,157,084Antigen specific T cell factors.Mol Cell Biochem1980https://conductscience.org/library/papers/6157084PubMed
3,923,947Human interferon-gamma induces expression of HLA-DR on keratinocytes and melanocytes.Arch Dermatol Res1985https://conductscience.org/library/papers/3923947PubMed
3,485,568Characterization of a T-lymphocyte membrane protein involved in T-cell function: its contribution to T-cell recognition or cellular interaction.Immunology1986https://conductscience.org/library/papers/3485568PubMed

1 to 10 of 22

See all 22 cited by

Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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