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Paper6292841

Accurate in vitro splicing of human beta-globin RNA.

Kole R and 1 other. Nucleic Acids Res, 1982. Cited by 68 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Accurate in vitro splicing of human beta-globin RNA. Papers, record 6292841. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/6292841

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Accurate in vitro splicing of human beta-globin RNA.
PubMed
Journal
Nucleic Acids Res
PubMed
Year
1982
PubMed
Publication types
Journal Article, Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
68
iCite
Relative citation ratio, by iCite
1.16
iCite
Revised in PubMed
2022-03-11
PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Kole RR
2Weissman SMS M

Source PubMed

Topics11

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
GlobinsMajor topic
RNA, MessengerMajor topic
Transcription, GeneticMajor topic
Base Sequence
DNA
DNA Restriction Enzymes
Genes
HeLa Cells
Humans
Plasmids
Templates, Genetic

Source PubMed

Grants1

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated by
CA-16038NCI NIH HHSUnited StatesP01CA016038PubMed and NIH

Source NIH RePORTER

References24

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
14,708,091
Mammalian deoxyribonucleic acid-dependent ribonucleic acid polymerases. I. Purification and properties of an -amanitin-sensitive ribonucleic acid polymerase and stimulatory factors from HeLa and KB cells.
J Biol Chem1973https://conductscience.org/library/papers/4708091PubMed
2631,324The use of thin acrylamide gels for DNA sequencing.FEBS Lett1978https://conductscience.org/library/papers/631324PubMed
3728,996The isolation and characterization of linked delta- and beta-globin genes from a cloned library of human DNA.Cell1978https://conductscience.org/library/papers/728996PubMed
4112,912RNA processing and the intervening sequence problem.Annu Rev Biochem1979https://conductscience.org/library/papers/112912PubMed
57,350,545Are snRNPs involved in splicing?Nature1980https://conductscience.org/library/papers/7350545PubMed
6529,286RNA synthesis in isolated nuclei: identification and comparison of adenovirus 2 encoded transcripts synthesized in vitro and vivo.J Mol Biol1979https://conductscience.org/library/papers/529286PubMed
76,154,870Determination of RNA sequences by primer directed synthesis and sequencing of their cDNA transcripts.Methods Enzymol1980https://conductscience.org/library/papers/6154870PubMed
87,407,909Beta Thalassemia: mutations which affect processing of the beta-Globin mRNA precursor.Cell1980https://conductscience.org/library/papers/7407909PubMed
96,933,441DNA-dependent transcription of adenovirus genes in a soluble whole-cell extract.Proc Natl Acad Sci U S A1980https://conductscience.org/library/papers/6933441PubMed
106,254,016Cloning and characterization of DNA sequences surrounding the human gamma-, delta-, and beta-globin genes.Proc Natl Acad Sci U S A1980https://conductscience.org/library/papers/6254016PubMed
116,933,479Processing of human beta-globin mRNA precursor to mRNA is defective in three patients with beta+-thalassemia.Proc Natl Acad Sci U S A1980https://conductscience.org/library/papers/6933479PubMed
126,254,664The nucleotide sequence of the human beta-globin gene.Cell1980https://conductscience.org/library/papers/6254664PubMed
136,256,354Transcription of Simian virus 40 DNA in a HeLa whole cell extract.J Biol Chem1981https://conductscience.org/library/papers/6256354PubMed
147,226,224Speculations on RNA splicing.Cell1981https://conductscience.org/library/papers/7226224PubMed
156,940,164A small nuclear ribonucleoprotein is required for splicing of adenoviral early RNA sequences.Proc Natl Acad Sci U S A1981https://conductscience.org/library/papers/6940164PubMed
166,165,649Structural analysis of templates and RNA polymerase III transcripts of Alu family sequences interspersed among the human beta-like globin genes.Gene1981https://conductscience.org/library/papers/6165649PubMed
176,264,477Base substitution in an intervening sequence of a beta+-thalassemic human globin gene.Proc Natl Acad Sci U S A1981https://conductscience.org/library/papers/6264477PubMed
186,791,577Organization and expression of eucaryotic split genes coding for proteins.Annu Rev Biochem1981https://conductscience.org/library/papers/6791577PubMed
196,945,572Transcription and processing of adenoviral RNA by extracts from HeLa cells.Proc Natl Acad Sci U S A1981https://conductscience.org/library/papers/6945572PubMed
206,946,482In vitro splicing of purified precursor RNAs specified by early region 2 of the adenovirus 2 genome.Proc Natl Acad Sci U S A1981https://conductscience.org/library/papers/6946482PubMed

See all 24 references

Cited by27

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 68 citations.

PMIDTitleJournalYearIn PapersSource
32,020,016Cyclosporine H Improves the Multi-Vector Lentiviral Transduction of Murine Haematopoietic Progenitors and Stem Cells.Sci Rep2020https://conductscience.org/library/papers/32020016PubMed
29,321,806Development of an in vitro pre-mRNA splicing assay using plant nuclear extract.Plant Methods2018https://conductscience.org/library/papers/29321806PubMed
24,241,231Transcription of a legumin gene from pea (Pisum sativum L.) in vitro.Planta1985https://conductscience.org/library/papers/24241231PubMed
21,264,352The in vivo kinetics of RNA polymerase II elongation during co-transcriptional splicing.PLoS Biol2011https://conductscience.org/library/papers/21264352PubMed
17,630,325Concurrent splicing and transcription are not sufficient to enhance splicing efficiency.RNA2007https://conductscience.org/library/papers/17630325PubMed
16,453,710Monocot and dicot pre-mRNAs are processed with different efficiencies in transgenic tobacco.EMBO J1986https://conductscience.org/library/papers/16453710PubMed
10,999,609Coupled in vitro synthesis and splicing of RNA polymerase II transcripts.RNA2000https://conductscience.org/library/papers/10999609PubMed
6,589,618In vitro-synthesized adenovirus 2 messenger RNA precursors are accurately spliced by nuclear extracts.Proc Natl Acad Sci U S A1984https://conductscience.org/library/papers/6589618PubMed
6,577,417Splicing of adenovirus RNA in a cell-free transcription system.Proc Natl Acad Sci U S A1983https://conductscience.org/library/papers/6577417PubMed
6,361,523Initiation by RNA polymerase II and formation of runoff transcripts containing unblocked and unmethylated 5' termini.Mol Cell Biol1983https://conductscience.org/library/papers/6361523PubMed
6,326,137Efficient coupled transcription and mRNA splicing in vitro using plasmids derived from early region 3 of adenovirus 2 and a nondefective adenovirus-simian virus 40 hybrid.Proc Natl Acad Sci U S A1984https://conductscience.org/library/papers/6326137PubMed
6,310,149Microinjected simian virus 40 cRNA is spliced, as evidenced by electron microscopy.J Virol1983https://conductscience.org/library/papers/6310149PubMed
6,308,613In vitro assembly of a pre-messenger ribonucleoprotein.Proc Natl Acad Sci U S A1983https://conductscience.org/library/papers/6308613PubMed
6,208,548U1 RNA-protein complex preferentially binds to both 5' and 3' splice junction sequences in RNA or single-stranded DNA.Proc Natl Acad Sci U S A1984https://conductscience.org/library/papers/6208548PubMed
6,186,991Accurate and efficient in vitro splicing of purified precursor RNAs specified by early region 2 of the adenovirus 2 genome.Nucleic Acids Res1983https://conductscience.org/library/papers/6186991PubMed
6,083,441Isolation and characterization of the RNA2, RNA3, and RNA11 genes of Saccharomyces cerevisiae.Mol Cell Biol1984https://conductscience.org/library/papers/6083441PubMed
4,092,689Purification of a protein required for the splicing of pre-mRNA and its separation from the lariat debranching enzyme.EMBO J1985https://conductscience.org/library/papers/4092689PubMed
4,011,434The 5.8S ribosomal RNA gene of Trypanosoma brucei: structural and transcriptional studies.Nucleic Acids Res1985https://conductscience.org/library/papers/4011434PubMed
3,737,399The different intron 2 species excised in vivo from the E2A premRNA of adenovirus-2: an approach to analyse alternative splicing.Nucleic Acids Res1986https://conductscience.org/library/papers/3737399PubMed
3,517,868Fractionation and characterization of a yeast mRNA splicing extract.Proc Natl Acad Sci U S A1986https://conductscience.org/library/papers/3517868PubMed

See all 27 cited by

Genes1

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn Genes
HBB3,043PubTator's text mininghttps://conductscience.org/library/genes/3043

Source NCBI Gene

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

None in this release

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  • Data

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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