Paper · 6315420

Electrophysiological characterization, solubilization and purification of the Tityus gamma toxin receptor associated with the gating component of the Na+ channel from rat brain.

Barhanin J and 6 others. EMBO J, 1983. Cited by 66 papers, by iCite.

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ConductScience Library. Electrophysiological characterization, solubilization and purification of the Tityus gamma toxin receptor associated with the gating component of the Na+ channel from rat brain. Papers, record 6315420. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/6315420

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Electrophysiological characterization, solubilization and purification of the Tityus gamma toxin receptor associated with the gating component of the Na+ channel from rat brain.; PubMed
Journal: EMBO J; PubMed
Year: 1983; PubMed
Publication types: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/6315420/; PubMed
DOI: https://doi.org/10.1002/j.1460-2075.1983.tb01521.x; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC555208/; PubMed
The journal: https://conductscience.org/library/journal-index/8208664; PubMed
Citations, by iCite: 66; iCite
Relative citation ratio, by iCite: 2.05; iCite
Revised in PubMed: 2022-05-11; PubMed

Authors7

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Barhanin J	J
2	Pauron D	D
3	Lombet A	A
4	Norman RI	R I
5	Vijverberg HP	H P
6	Giglio JR	J R
7	Lazdunski M	M

Source PubMed

Topics12

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Brain	Major topic
Ion Channels	Major topic
Receptors, Cholinergic	Major topic
Scorpion Venoms	Major topic
Sodium	Major topic
Sodium Channels	Major topic
Action Potentials
Animals
Cells, Cultured
Molecular Weight
Neuroblastoma
Rats

Source PubMed

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Comments and corrections0

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References23

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	6,153,529	Binding of scorpion toxins to rat brain synaptosomal fraction. Effects of membrane potential, ions, and other neurotoxins.	Biochemistry	1980	https://conductscience.org/library/papers/6153529	PubMed
2	532,965	A rapid and precise assay for tetrodotoxin binding to detergent extracts of excitable tissues.	Anal Biochem	1979	https://conductscience.org/library/papers/532965	PubMed
3	6,246,486	Purification from rat sarcolemma of the saxitoxin-binding component of the excitable membrane sodium channel.	Proc Natl Acad Sci U S A	1980	https://conductscience.org/library/papers/6246486	PubMed
4	6,103,536	Binding of sea anemone toxin to receptor sites associated with gating system of sodium channel in synaptic nerve endings in vitro.	Proc Natl Acad Sci U S A	1980	https://conductscience.org/library/papers/6103536	PubMed
5	6,162,199	Ultrasensitive stain for proteins in polyacrylamide gels shows regional variation in cerebrospinal fluid proteins.	Science	1981	https://conductscience.org/library/papers/6162199	PubMed
6	6,270,687	Purification of the saxitoxin receptor of the sodium channel from rat brain.	Proc Natl Acad Sci U S A	1981	https://conductscience.org/library/papers/6270687	PubMed
7	6,122,211	Apamin as a selective blocker of the calcium-dependent potassium channel in neuroblastoma cells: voltage-clamp and biochemical characterization of the toxin receptor.	Proc Natl Acad Sci U S A	1982	https://conductscience.org/library/papers/6122211	PubMed
8	6,288,608	Biochemical studies of the excitable membrane sodium channel.	Int Rev Neurobiol	1982	https://conductscience.org/library/papers/6288608	PubMed
9	6,290,472	Tityus serrulatus venom contains two classes of toxins. Tityus gamma toxin is a new tool with a very high affinity for studying the Na+ channel.	J Biol Chem	1982	https://conductscience.org/library/papers/6290472	PubMed
10	6,292,214	The saxitoxin receptor of the sodium channel from rat brain. Evidence for two nonidentical beta subunits.	J Biol Chem	1982	https://conductscience.org/library/papers/6292214	PubMed

1 to 10 of 23

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Cited by13

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 66 citations.

PMID	Title	Journal	Year	In Papers	Source
36,188,602	Apamin structure and pharmacology revisited.	Front Pharmacol	2022	https://conductscience.org/library/papers/36188602	PubMed
30,873,475	Scorpion and spider venoms in cancer treatment: state of the art, challenges, and perspectives.	J Clin Transl Res	2017	https://conductscience.org/library/papers/30873475	PubMed
15,678,093	Selective release of ATP from sympathetic nerves of rat vas deferens by the toxin TsTX-I from Brazilian scorpion Tityus serrulatus.	Br J Pharmacol	2005	https://conductscience.org/library/papers/15678093	PubMed
9,350,011	Expression of ion channels during differentiation of a human skeletal muscle cell line.	J Muscle Res Cell Motil	1997	https://conductscience.org/library/papers/9350011	PubMed
6,325,173	Reconstitution of highly purified saxitoxin-sensitive Na+-channels into planar lipid bilayers.	EMBO J	1984	https://conductscience.org/library/papers/6325173	PubMed
6,324,066	Tityus gamma toxin, a high affinity effector of the Na+ channel in muscle, with a selectivity for channels in the surface membrane.	Pflugers Arch	1984	https://conductscience.org/library/papers/6324066	PubMed
6,089,101	The effect of Tityus serrulatus scorpion toxin gamma on Na channels in neuroblastoma cells.	Pflugers Arch	1984	https://conductscience.org/library/papers/6089101	PubMed
2,580,299	A monoclonal immunotoxin acting on the Na+ channel, with properties similar to those of a scorpion toxin.	Proc Natl Acad Sci U S A	1985	https://conductscience.org/library/papers/2580299	PubMed
2,439,979	Blocking of the squid axon K+ channel by noxiustoxin: a toxin from the venom of the scorpion Centruroides noxius.	Pflugers Arch	1987	https://conductscience.org/library/papers/2439979	PubMed
2,432,607	Topographical localization of the C-terminal region of the voltage-dependent sodium channel from Electrophorus electricus using antibodies raised against a synthetic peptide.	Proc Natl Acad Sci U S A	1987	https://conductscience.org/library/papers/2432607	PubMed

1 to 10 of 13

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PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

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NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

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NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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