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Paper63533

Genetic control of the immune response to staphylococcal nuclease. IV. H-2-linked control of the relative proportions of antibodies produced to different determinants of native nuclease.

Berzofsky JA and 3 others. J Exp Med, 1977. Cited by 62 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Genetic control of the immune response to staphylococcal nuclease. IV. H-2-linked control of the relative proportions of antibodies produced to different determinants of native nuclease. Papers, record 63533. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/63533

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Genetic control of the immune response to staphylococcal nuclease. IV. H-2-linked control of the relative proportions of antibodies produced to different determinants of native nuclease.
PubMed
Journal
J Exp Med
PubMed
Year
1977
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
62
iCite
Relative citation ratio, by iCite
1.27
iCite
Revised in PubMed
2019-05-08
PubMed

Authors4

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Berzofsky JAJ A
2Schechter ANA N
3Shearer GMG M
4Sachs DHD H

Source PubMed

Topics16

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Antibodies, BacterialMajor topic
Antibody FormationMajor topic
Antibody SpecificityMajor topic
GenesMajor topic
Histocompatibility AntigensMajor topic
Micrococcal NucleaseMajor topic
Animals
B-Lymphocytes
Epitopes
Genetic Linkage
Immunologic Memory
Mice
Mice, Inbred Strains
Peptides
Protein Conformation
Structure-Activity Relationship

Source PubMed

References11

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
11,090,698Cell interactions between histoincompatible T and B lymphocytes. VII. Cooperative responses between lymphocytes are controlled by genes in the I region of the H-2 complex.J Exp Med1975https://conductscience.org/library/papers/1090698PubMed
21,171,246An immunological approach to the conformational equilibrium of staphylococcal nuclease.J Mol Biol1975https://conductscience.org/library/papers/1171246PubMed
3163,827The mechanism of stabilization of the structure of nuclease-T by binding of ligands.J Biol Chem1975https://conductscience.org/library/papers/163827PubMed
44,118,873An immunologic approach to the conformational equilibria of polypeptides.Proc Natl Acad Sci U S A1972https://conductscience.org/library/papers/4118873PubMed
54,187,525The genetic control of antibody specificity.J Exp Med1969https://conductscience.org/library/papers/4187525PubMed
6830,786Genetic control of the immune response to staphylococcal nuclease. III. Time-course and correlation between the response to native nuclease and the response to its polypeptide fragments.J Exp Med1977https://conductscience.org/library/papers/830786PubMed
74,908,392Genetic control of specific immune responses.Adv Immunol1969https://conductscience.org/library/papers/4908392PubMed
85,009,706
Specific immune response genes of the guinea pig. V. Influence of the GA and GT immune response genes on the specificity of cellular and humoral immune responses to a terpolymer of L-glutamic acid, L-alanine, and L-tyrosine.
J Exp Med1972https://conductscience.org/library/papers/5009706PubMed
956,408Genetic control of the immune response to nuclease. II. Detection of idiotypic determinants by the inhibition of antibody-mediated nuclease inactivation.J Immunol1976https://conductscience.org/library/papers/56408PubMed
10815,254Antibodies to an NH2-terminal fragment of betaS globin. II. Specificity and isolation of antibodies for the sickle mutation.J Biol Chem1976https://conductscience.org/library/papers/815254PubMed
114,360,861Genetic control of the immune response: the effect of non-H-2 linked genes on antibody production.J Immunol1974https://conductscience.org/library/papers/4360861PubMed

Cited by13

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 62 citations.

PMIDTitleJournalYearIn PapersSource
33,571,241In silico analysis suggests less effective MHC-II presentation of SARS-CoV-2 RBM peptides: Implication for neutralizing antibody responses.PLoS One2021https://conductscience.org/library/papers/33571241PubMed
6,432,932A major anti-myoglobin idiotype. Influence of H-2-linked Ir genes on idiotype expression.J Exp Med1984https://conductscience.org/library/papers/6432932PubMed
6,201,979T-B reciprocity. An Ia-restricted epitope-specific circuit regulating T cell-B cell interaction and antibody specificity.Surv Immunol Res1983https://conductscience.org/library/papers/6201979PubMed
6,195,108RT1-linked Ir and Is genes control the immune response to bovine insulin in the rat.Immunogenetics1983https://conductscience.org/library/papers/6195108PubMed
3,117,691Genetic control of immune response to staphylococcal exfoliative toxin A in mice.Infect Immun1987https://conductscience.org/library/papers/3117691PubMed
2,450,949Limiting dilution comparison of the repertoires of high and low responder MHC-restricted T cells.J Exp Med1988https://conductscience.org/library/papers/2450949PubMed
2,414,644Genetic control of immune response to staphylococcal nuclease. XII: Analysis of nuclease antigenic determinants using anti-nuclease monoclonal antibodies.Mol Cell Biochem1985https://conductscience.org/library/papers/2414644PubMed
830,786Genetic control of the immune response to staphylococcal nuclease. III. Time-course and correlation between the response to native nuclease and the response to its polypeptide fragments.J Exp Med1977https://conductscience.org/library/papers/830786PubMed
415,108Genetic control of the immune response to staphylococcal nuclease. VII. Role of non-H2-linked genes in the control of the anti-nuclease antibody response.J Exp Med1978https://conductscience.org/library/papers/415108PubMed
102,725The involvement of suppressor T cells in Ir gene regulation of secondary antibody responses of primed (responder X nonresponder)F1 mice to macrophage-bound L-glutamic acid60-L-alanine30-L-tyrosine.J Exp Med1978https://conductscience.org/library/papers/102725PubMed
91,172Distinct H-2-linked Ir genes control both antibody and T cell responses to different determinants on the same antigen, myoglobin.Proc Natl Acad Sci U S A1979https://conductscience.org/library/papers/91172PubMed
83,296Evidence that L-rhamnose is the antigenic determinant of hyporesponsiveness of BALB/c mice to Klebsiella pneumoniae type 47.Infect Immun1978https://conductscience.org/library/papers/83296PubMed
77,307Genetic control of the immune response to staphylococcal nuclease. VIII. Mapping of genes for antibodies to different antigenic regions of nuclease.J Exp Med1978https://conductscience.org/library/papers/77307PubMed

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

None in this release

  • Grants
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  • Comments and corrections
  • Genes
  • Drugs
  • Data

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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