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Paper6595

Biological expressions of lymphocyte activation. V. Characterization of a soluble immune response suppressor (SIRS) produced by concanavalin A-activated spleen cells.

Tadakuma T and 4 others. J Immunol, 1976. Cited by 116 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Biological expressions of lymphocyte activation. V. Characterization of a soluble immune response suppressor (SIRS) produced by concanavalin A-activated spleen cells. Papers, record 6595. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/6595

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Biological expressions of lymphocyte activation. V. Characterization of a soluble immune response suppressor (SIRS) produced by concanavalin A-activated spleen cells.
PubMed
Journal
J Immunol
PubMed
Year
1976
PubMed
Publication types
Journal Article, Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
116
iCite
Relative citation ratio, by iCite
3.04
iCite
Revised in PubMed
2008-11-21
PubMed

Authors5

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Tadakuma TT
2Kühner ALA L
3Rich RRR R
4David JRJ R
5Pierce CWC W

Source PubMed

Topics19

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Immunosuppressive AgentsMajor topic
Lymphocyte ActivationMajor topic
SpleenMajor topic
Absorption
Animals
Antibodies, Anti-Idiotypic
Centrifugation, Isopycnic
Chromatography, Gel
Concanavalin A
Deoxyribonucleases
Dialysis
Electrophoresis, Polyacrylamide Gel
Hot Temperature
Hydrogen-Ion Concentration
Macrophage Migration-Inhibitory Factors
Mice
Mice, Inbred C57BL
Ribonucleases
Trypsin

Source PubMed

Cited by22

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 116 citations.

PMIDTitleJournalYearIn PapersSource
7,307,347Generation of a soluble immune response suppressor factor (IRSF) by unstimulated leukocytes of healthy subjects.Clin Exp Immunol1981https://conductscience.org/library/papers/7307347PubMed
7,007,219Purification and properties of a factor from leukaemic T cells which non-specifically enhances the antibody response.Immunology1981https://conductscience.org/library/papers/7007219PubMed
6,975,476Conversion of soluble immune response suppressor to macrophage-derived suppressor factor by peroxide.Proc Natl Acad Sci U S A1981https://conductscience.org/library/papers/6975476PubMed
6,682,089Relationship between a spleen-derived immunosuppressive peptide 'SDIP' and the 'Facteur thymique sérique' (FTS): biochemical and biological comparison of the two factors.Immunology1983https://conductscience.org/library/papers/6682089PubMed
6,611,297Functional properties of lymphocytes isolated from murine small intestinal epithelium.Immunology1984https://conductscience.org/library/papers/6611297PubMed
6,458,429Production of migration inhibition factor (MIF) by purified human T cell subpopulations.Clin Exp Immunol1981https://conductscience.org/library/papers/6458429PubMed
6,454,650Bovine con A-induced suppressor cells: generation, macrophage requirements and possible mechanisms of regulatory action.Immunology1981https://conductscience.org/library/papers/6454650PubMed
6,444,265Macrophages: modulators of immunity. Parke-Davis Award Lecture.Am J Pathol1980https://conductscience.org/library/papers/6444265PubMed
6,345,031In vitro proliferative response to M. leprae and PPD of isolated T cell subsets from leprosy patients.Clin Exp Immunol1983https://conductscience.org/library/papers/6345031PubMed
6,334,714Purification and characterization of a mannose-containing disaccharide obtained from human pregnancy urine. A new immunoregulatory saccharide.J Exp Med1984https://conductscience.org/library/papers/6334714PubMed
3,180,511Identification of two suppressor factors induced by early pregnancy factor.Clin Exp Immunol1988https://conductscience.org/library/papers/3180511PubMed
2,461,966Identification of a histamine release inhibitory factor produced by human mononuclear cells in vitro.J Clin Invest1988https://conductscience.org/library/papers/2461966PubMed
864,380Suppression of IgE antibody production in SJL mice. III. Characterization of a suppressor substance extracted from normal SJL spleen cells.J Exp Med1977https://conductscience.org/library/papers/864380PubMed
390,085A hemolytic plaque assay for activated murine T cells.J Exp Med1979https://conductscience.org/library/papers/390085PubMed
338,477Partial characterization of a T cell-derived factor that suppresses the initiation of the humoral immune response in vitro.Immunology1977https://conductscience.org/library/papers/338477PubMed
324,897Non-specific suppression of the initiation of the immune response to a heterologous immunogen by supernatants from specifically stimulated, primed lymphoid cells.Immunology1977https://conductscience.org/library/papers/324897PubMed
315,993
Soluble factors in tolerance and contact sensitivity to 2,4-dinitrofluorobenzene in mice. III. Histocompatibility antigens associated with the hapten dinitrophenol serve as target molecules on 2,4-dinitrofluorobenzene-immune T cells for soluble suppressor factor.
J Exp Med1979https://conductscience.org/library/papers/315993PubMed
312,171Immunological dysfunctions in multiple sclerosis. I. Diminution of 'active' thymus-derived lymphocytes and presence of immunomodulating serum factors.Clin Exp Immunol1979https://conductscience.org/library/papers/312171PubMed
304,780Stimulation of a human B-lymphocyte line by anti-immunoglobulin and its concanavalin A-induced suppression by a T-cell line.Clin Exp Immunol1977https://conductscience.org/library/papers/304780PubMed
84,040Regulatory mechanisms in cell-mediated immune responses. VII. Presence of I-C subregion determinants on mixed leukocyte reaction suppressor factor.J Exp Med1979https://conductscience.org/library/papers/84040PubMed

See all 22 cited by

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

None in this release

  • Grants
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  • References
  • Genes
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  • Data

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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