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Paper84040

Regulatory mechanisms in cell-mediated immune responses. VII. Presence of I-C subregion determinants on mixed leukocyte reaction suppressor factor.

Rich SS and 2 others. J Exp Med, 1979. Cited by 58 papers, by iCite.

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ConductScience Library. Regulatory mechanisms in cell-mediated immune responses. VII. Presence of I-C subregion determinants on mixed leukocyte reaction suppressor factor. Papers, record 84040. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/84040

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Regulatory mechanisms in cell-mediated immune responses. VII. Presence of I-C subregion determinants on mixed leukocyte reaction suppressor factor.
PubMed
Journal
J Exp Med
PubMed
Year
1979
PubMed
Publication types
Journal Article, Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
58
iCite
Relative citation ratio, by iCite
1.37
iCite
Revised in PubMed
2021-12-03
PubMed

Authors3

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Rich SSS S
2David CSC S
3Rich RRR R

Source PubMed

Topics11

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
H-2 AntigensMajor topic
Immunity, CellularMajor topic
Immunosuppression TherapyMajor topic
Major Histocompatibility ComplexMajor topic
Animals
Chromosome Mapping
Epitopes
Genes
Lymphocyte Culture Test, Mixed
Mice
Mice, Inbred Strains

Source PubMed

References28

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
11,085,338A new I subregion (I-J) marked by a locus (Ia-4) controlling surface determinants on suppressor T lymphocytes.J Exp Med1976https://conductscience.org/library/papers/1085338PubMed
21,085,339
Properties of the antigen-specific suppressive T-cell factor in the regulation of antibody response of the mouse. IV. Special subregion assignment of the gene(s) that codes for the suppressive T-cell factor in the H-2 histocompatibility complex.
J Exp Med1976https://conductscience.org/library/papers/1085339PubMed
31,086,882Regulatory mechanisms in cell-mediated immune responses. IV. Expression of a receptor for mixed lymphocyte reaction suppressor factor on activated T lymphocytes.J Exp Med1976https://conductscience.org/library/papers/1086882PubMed
41,091,708Regulation of the immune response: production of a soluble suppressor by immune spleen cells in vitro.J Immunol1975https://conductscience.org/library/papers/1091708PubMed
51,117,139Serologic and biochemical studies of the Ia system of the mouse H-2 gene complex. Further evidence for I-C subregion.J Immunol1975https://conductscience.org/library/papers/1117139PubMed
6129,500Regulatory mechanisms in cell-mediated immune responses. III. I-region control of suppressor cell interaction with responder cells in mixed lymphocyte reactions.J Exp Med1976https://conductscience.org/library/papers/129500PubMed
7144,767Regulatory mechanisms in cell-mediated immune responses. VI. Interaction of H-2 and non-H-2 genes in elaboration of mixed leukocyte reaction suppressor factor.J Exp Med1977https://conductscience.org/library/papers/144767PubMed
8144,771The role of gene products of the I-J subregion in mixed lymphocyte reactions.J Exp Med1977https://conductscience.org/library/papers/144771PubMed
9270,747Reduction of syngeneic tumor growth by an anti-I-J-alloantiserum.Proc Natl Acad Sci U S A1977https://conductscience.org/library/papers/270747PubMed
10300,709Regulatory substances produced by lymphocytes--IV. Further characterization of the inhibitor of DNA synthesis (IDS).Immunochemistry1977https://conductscience.org/library/papers/300709PubMed
11302,311In vitro analysis of allogeneic lymphocyte interaction. I. Characterization and cellular origin of an Ia-positive helper factor-allogeneic effect factor.J Exp Med1977https://conductscience.org/library/papers/302311PubMed
12303,682Enrichment of specific suppressor T cells and characterization of their surface markers.J Exp Med1977https://conductscience.org/library/papers/303682PubMed
13410,029Potentiation of a primary in vivo antibody response by alloantisera against gene products of the I region of the H-2 complex.Proc Natl Acad Sci U S A1977https://conductscience.org/library/papers/410029PubMed
144,133,256Lymphocyte antigens controlled by the Ir region of the mouse H-2 complex.Transplantation1974https://conductscience.org/library/papers/4133256PubMed
15415,106Suppressor-cell induction in vitro. IV. Target of antigen-specific suppressor factor and its genetic relationships.J Exp Med1978https://conductscience.org/library/papers/415106PubMed
1653,264Regulatory mechanisms in cell-mediated immune responses. II. A genetically restricted suppressor of mixed lymphocyte reactions released by alloantigen-activated spleen cells.J Exp Med1975https://conductscience.org/library/papers/53264PubMed
176,595Biological expressions of lymphocyte activation. V. Characterization of a soluble immune response suppressor (SIRS) produced by concanavalin A-activated spleen cells.J Immunol1976https://conductscience.org/library/papers/6595PubMed
1867,171
Immunosuppressive factor(s) extracted from lymphoid cells of nonresponder mice primed with L-glutamic acid60-L-alanine30-L-tyrosine10 (GAT) III. Immunochemical properties of the GAT-specific suppressive factor.
J Exp Med1977https://conductscience.org/library/papers/67171PubMed
1968,991Immunosuppressive factor(s) specific for L-glutamic acid50-L-tyrosine50 (GT) II. Presence of I-J determinants on the GT-suppressive factor.J Exp Med1977https://conductscience.org/library/papers/68991PubMed
2068,992The I-J subregion codes for determinats on suppressor factor(s) which limit the contact sensitivity response to picryl chloride.J Exp Med1977https://conductscience.org/library/papers/68992PubMed

See all 28 references

Cited by15

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 58 citations.

PMIDTitleJournalYearIn PapersSource
6,966,320Selective suppression of the major idiotypic component of an antihapten response by soluble T cell-derived factors with idiotypic or anti-idiotypic receptors.J Exp Med1980https://conductscience.org/library/papers/6966320PubMed
6,792,727Helper and suppressor T cell factors.Springer Semin Immunopathol1980https://conductscience.org/library/papers/6792727PubMed
6,600,235Cyclosporin A-treated guinea pig responder cells secrete a genetically restricted factor that suppresses the mixed leukocyte reaction.J Clin Invest1983https://conductscience.org/library/papers/6600235PubMed
6,460,694Requirement for the location of both appropriate and irrelevant H-2 antigens on the same stimulator cell for unspecific DNA-synthesis inhibition by the H-2-antigen-primed, specific suppressor T cells.Immunogenetics1982https://conductscience.org/library/papers/6460694PubMed
6,459,996
Regulation of the human allogenic proliferative response in vitro. II. Production of soluble suppressor factors by suppressor T cells and evidence in favor of "acceptor" cells for suppression among unprimed lymphocytes.
Immunogenetics1981https://conductscience.org/library/papers/6459996PubMed
6,227,676Suppressive mechanisms in alloantigen-induced T cell responses.J Exp Med1983https://conductscience.org/library/papers/6227676PubMed
6,217,278Regulation of granulomatous inflammation in murine schistosomiasis. II. T suppressor cell-derived, I-C subregion-encoded soluble suppressor factor mediates regulation of lymphokine production.J Exp Med1983https://conductscience.org/library/papers/6217278PubMed
6,193,232Regulatory mechanisms in cell-mediated immune responses. Role of I-J and I-C determinants in the activation of H-2I and H-2K/D alloantigen-specific suppressor T cells.J Exp Med1983https://conductscience.org/library/papers/6193232PubMed
6,176,663Interferon inhibits the generation of allospecific suppressor T lymphocytes.J Exp Med1982https://conductscience.org/library/papers/6176663PubMed
6,161,371Murine T cell Ia antigens: specificity Iat.46 maps in I-J to I-E chromosomal segment of H-2 complex.Proc Natl Acad Sci U S A1980https://conductscience.org/library/papers/6161371PubMed
6,157,644Intra-H-2 recombination in the mouse. III. I-Region characterization of haplotypes H-2at2, H-2at3 and H-2a2.Immunogenetics1980https://conductscience.org/library/papers/6157644PubMed
6,155,422Regulation of granulomatous inflammation in murine schistosomiasis. In vitro characterization of T lymphocyte subsets involved in the production and suppression of migration inhibition factor.J Exp Med1980https://conductscience.org/library/papers/6155422PubMed
3,884,497The effect of H-2IJ disparity on induction of allotransplantation tolerance by lentil lectin.Immunogenetics1985https://conductscience.org/library/papers/3884497PubMed
315,993
Soluble factors in tolerance and contact sensitivity to 2,4-dinitrofluorobenzene in mice. III. Histocompatibility antigens associated with the hapten dinitrophenol serve as target molecules on 2,4-dinitrofluorobenzene-immune T cells for soluble suppressor factor.
J Exp Med1979https://conductscience.org/library/papers/315993PubMed
91,654Regulatory mechanisms in cell-mediated immune responses. VIII. Differential expression of I-region determinants by suppressor cells and their targets in suppression of mixed leukocyte reactions.J Exp Med1979https://conductscience.org/library/papers/91654PubMed

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

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  • ClinicalTrials.govNo license stated
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  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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