Paper · 6780980

Organization of the sequences flanking immunoglobulin heavy chain genes and their role in class switching.

Tyler BM and 1 other. Nucleic Acids Res, 1980. Cited by 7 papers, by iCite.

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ConductScience Library. Organization of the sequences flanking immunoglobulin heavy chain genes and their role in class switching. Papers, record 6780980. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/6780980

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Organization of the sequences flanking immunoglobulin heavy chain genes and their role in class switching.; PubMed
Journal: Nucleic Acids Res; PubMed
Year: 1980; PubMed
Publication types: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/6780980/; PubMed
DOI: https://doi.org/10.1093/nar/8.23.5579; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC324327/; PubMed
The journal: https://conductscience.org/library/journal-index/0411011; PubMed
Citations, by iCite: 7; iCite
Relative citation ratio, by iCite: 0.13; iCite
Revised in PubMed: 2019-05-01; PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	Kind	ORCID iD
1	Tyler BM	B M
2	Adams JM	J M

Source PubMed

Topics12

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Genes, MHC Class II	Major topic
Immunoglobulin Heavy Chains	Major topic
Animals
Base Sequence
Cloning, Molecular
DNA
Gene Amplification
Mice
Neoplasms, Experimental
Nucleic Acid Heteroduplexes
Plasmacytoma
Recombination, Genetic

Source PubMed

Grants1

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes it	Agency	Country	NIH project	Stated by
R01-CA12421	NCI NIH HHS	United States	R01CA012421	PubMed and NIH

Source NIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References42

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	4,160,200	The molecular basis of antibody formation: a paradox.	Proc Natl Acad Sci U S A	1965	https://conductscience.org/library/papers/4160200	PubMed
2	5,343,515	Rate of fixation of nucleotide substitutions in evolution.	Nature	1969	https://conductscience.org/library/papers/5343515	PubMed
3	4,944,929	A study in evolution: the DNA base sequence homology between coliphages T7 and T3.	J Mol Biol	1971	https://conductscience.org/library/papers/4944929	PubMed
4	787,539	The molecular basis for length heterogeneity in ribosomal DNA from Xenopus laevis.	J Mol Biol	1976	https://conductscience.org/library/papers/787539	PubMed
5	403,010	Synthesis of hybrid bacterial plasmids containing highly repeated satellite DNA.	Cell	1977	https://conductscience.org/library/papers/403010	PubMed
6	408,084	Somatic changes in the content and context of immunoglobulin genes.	Cold Spring Harb Symp Quant Biol	1977	https://conductscience.org/library/papers/408084	PubMed
7	566,163	The nucleotide sequence of oocyte 5S DNA in Xenopus laevis. I. The AT-rich spacer.	Cell	1978	https://conductscience.org/library/papers/566163	PubMed
8	566,164	The nucleotide sequence of oocyte 5S DNA in Xenopus laevis. II. The GC-rich region.	Cell	1978	https://conductscience.org/library/papers/566164	PubMed
9	351,064	Sequential expression of immunoglobulin on developing mouse B lymphocytes: a systematic survey that suggests a model for the generation of immunoglobulin isotype diversity.	J Immunol	1978	https://conductscience.org/library/papers/351064	PubMed
10	97,665	Organization of immunoglobulin heavy chain genes and allelic deletion model.	Proc Natl Acad Sci U S A	1978	https://conductscience.org/library/papers/97665	PubMed

1 to 10 of 42

See all 42 references

Cited by2

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 7 citations.

PMID	Title	Journal	Year	In Papers	Source
6,804,950	mRNA for surface immunoglobulin gamma chains encodes a highly conserved transmembrane sequence and a 28-residue intracellular domain.	Proc Natl Acad Sci U S A	1982	https://conductscience.org/library/papers/6804950	PubMed
6,278,424	On immunoglobulin heavy chain gene switching: two gamma 2b genes are rearranged via switch sequences in MPC-11 cells but only one is expressed.	Nucleic Acids Res	1982	https://conductscience.org/library/papers/6278424	PubMed

Genes1

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes
IGHG3	3,502	PubTator's text mining	https://conductscience.org/library/genes/3502

Source NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

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ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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