Paper6804591

In vivo therapy of a murine B cell tumor (BCL1) using antibody-ricin A chain immunotoxins.

Krolick KA and 3 others. J Exp Med, 1982. Cited by 130 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. In vivo therapy of a murine B cell tumor (BCL1) using antibody-ricin A chain immunotoxins. Papers, record 6804591. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/6804591

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: In vivo therapy of a murine B cell tumor (BCL1) using antibody-ricin A chain immunotoxins.; PubMed
Journal: J Exp Med; PubMed
Year: 1982; PubMed
Publication types: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/6804591/; PubMed
DOI: https://doi.org/10.1084/jem.155.6.1797; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC2186702/; PubMed
The journal: https://conductscience.org/library/journal-index/2985109R; PubMed
Citations, by iCite: 130; iCite
Relative citation ratio, by iCite: 3.89; iCite
Revised in PubMed: 2019-05-08; PubMed

Authors4

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Krolick KA	K A
2	Uhr JW	J W
3	Slavin S	S
4	Vitetta ES	E S

Source PubMed

Topics17

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Antitoxins	Major topic
B-Lymphocytes	Major topic
Lectins	Major topic
Leukemia, Experimental	Major topic
Plant Lectins	Major topic
Plant Proteins	Major topic
Animals
Antibodies, Anti-Idiotypic
Cell Transformation, Neoplastic
Fluorescent Antibody Technique
Immunoglobulin delta-Chains
Leukocyte Count
Lymphoid Tissue
Mice
Mice, Inbred BALB C
Rabbits
Splenectomy

Source PubMed

Show 11 more topicsShow fewer topics

Grants4

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes it	Agency	Country	NIH project	Stated by	Source
AI-15387	NIAID NIH HHS	United States	R01AI015387	PubMed and NIH	NIH RePORTER
CA-28149	NCI NIH HHS	United States	R01CA028149	PubMed and NIH	NIH RePORTER
CA-30313	NCI NIH HHS	United States	R01CA030313	PubMed and NIH	NIH RePORTER
			R37CA028149	NIH	NIH RePORTER

References41

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	4,343,471	Antitumor effects of antibody-diphtheria toxin conjugates: use of hapten-coated tumor cells as an antigenic target.	J Natl Cancer Inst	1972	https://conductscience.org/library/papers/4343471	PubMed
2	1,090,697	Cell surface immunoglobulin. XI. The appearance of an IgD-like molecule on murine lymphoid cells during ontogeny.	J Exp Med	1975	https://conductscience.org/library/papers/1090697	PubMed
3	169,378	Antitumor effects of antibody-diphtheria toxin conjugates. II. Immunotherapy with conjugates directed against tumor antigens induced by simian virus 40.	J Natl Cancer Inst	1975	https://conductscience.org/library/papers/169378	PubMed
4	1,082,551	Preparation and characterisation of an antiserum to the mouse candidate for immunoglobulin D.	Nature	1976	https://conductscience.org/library/papers/1082551	PubMed
5	323,402	The relationship between surface immunoglobulin isotype and immune function of murine B lymphocytes. I. Surface immunoglobulin isotypes on primed B cells in the spleen.	J Exp Med	1977	https://conductscience.org/library/papers/323402	PubMed
6	17,647	Induction of specific tissue transplantation tolerance using fractionated total lymphoid irradiation in adult mice: long-term survival of allogeneic bone marrow and skin grafts.	J Exp Med	1977	https://conductscience.org/library/papers/17647	PubMed
7	894,051	Cell surface immunoglobulin. XXII. Reappearance of surface IgM and IgD on murine splenocytes after removal by capping.	J Immunol	1977	https://conductscience.org/library/papers/894051	PubMed
8	306,069	Spontaneous murine B-cell leukaemia.	Nature	1978	https://conductscience.org/library/papers/306069	PubMed
9	97,669	Rescue of immunoglobulin secretion from human neoplastic lymphoid cells by somatic cell hybridization.	Proc Natl Acad Sci U S A	1978	https://conductscience.org/library/papers/97669	PubMed
10	567,555	Properties of monoclonal antibodies to mouse Ig allotypes, H-2, and Ia antigens.	Curr Top Microbiol Immunol	1978	https://conductscience.org/library/papers/567555	PubMed
11	80,453	Antibody-linked cytotoxic agents in the treatment of cancer: current status and future prospects.	J Natl Cancer Inst	1978	https://conductscience.org/library/papers/80453	PubMed
12	109,513	Characterization of the spontaneous murine B cell leukemia (BCL1). III. Evidence for monoclonality by using an anti-idiotype antibody.	J Immunol	1979	https://conductscience.org/library/papers/109513	PubMed
13	313,960	Characterization of a spontaneous murine B cell leukemia (BCL1). I. Cell surface expression of IgM, IgD, Ia, and FcR.	J Immunol	1979	https://conductscience.org/library/papers/313960	PubMed
14	39,027	Allograft tolerance after total lymphoid irradiation (TLI).	Immunol Rev	1979	https://conductscience.org/library/papers/39027	PubMed
15	385,772	Murine B cell leukemia (BCL1): organ distribution and kinetics of growth as determined by fluorescence analysis with an anti-idiotypic antibody.	J Immunol	1979	https://conductscience.org/library/papers/385772	PubMed
16	496,982	Preparation of a hybrid of fragment Fab' of antibody and fragment A of diphtheria toxin and its cytotoxicity.	Biochem Biophys Res Commun	1979	https://conductscience.org/library/papers/496982	PubMed
17	6,965,909	Increased toxicity of diphtheria toxin for human lymphoblastoid cells following covalent linkage to anti-(human lymphocyte) globulin or its F(ab')2 fragment.	Eur J Biochem	1980	https://conductscience.org/library/papers/6965909	PubMed
18	121,100	Immunobiology of a spontaneous murine B cell leukemia (BCL1).	Immunol Rev	1979	https://conductscience.org/library/papers/121100	PubMed
19	94,899	BCL1, a murine model for chronic lymphocytic leukemia: use of the surface immunoglobulin idiotype for the detection and treatment of tumor.	Immunol Rev	1979	https://conductscience.org/library/papers/94899	PubMed
20	398,327	Xenogeneic monoclonal antibodies to mouse lymphoid differentiation antigens.	Immunol Rev	1979	https://conductscience.org/library/papers/398327	PubMed

Show 14 more referencesShow fewer referencesSee all 41 references

Cited by14

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 130 citations.

PMID	Title	Journal	Year	In Papers	Source
41,181,593	Clinically approved immunotoxins targeting hematological cancers: "the best of both worlds".	Front Pharmacol	2025	https://conductscience.org/library/papers/41181593	PubMed
9,227,858	Yeast killer systems.	Clin Microbiol Rev	1997	https://conductscience.org/library/papers/9227858	PubMed
8,481,059	IgG3 cryoglobulins in autoimmune MRL-lpr/lpr mice: immunopathogenesis, therapeutic approaches and relevance to similar human diseases.	Ann Rheum Dis	1993	https://conductscience.org/library/papers/8481059	PubMed
7,811,557	Radioimmunodetection of cancer of gastrointestinal tract and liver metastasis with I-131 anti-CEA and I-131 anti-CA19-9 monoclonal antibody cocktail (IMACIS-1).	Ann Nucl Med	1994	https://conductscience.org/library/papers/7811557	PubMed
7,513,431	Lyn tyrosine kinase signals cell cycle arrest but not apoptosis in B-lineage lymphoma cells.	Proc Natl Acad Sci U S A	1994	https://conductscience.org/library/papers/7513431	PubMed
6,577,942	Interferon-alpha conjugation to human osteogenic sarcoma monoclonal antibody 791T/36.	Cancer Immunol Immunother	1983	https://conductscience.org/library/papers/6577942	PubMed
6,351,310	Treatment of lymphoid tumors with anti-idiotype antibodies.	Springer Semin Immunopathol	1983	https://conductscience.org/library/papers/6351310	PubMed
3,543,527	Immunotoxin therapy of malignant melanoma.	Med Oncol Tumor Pharmacother	1986	https://conductscience.org/library/papers/3543527	PubMed
3,494,997	Complete suppression of in vivo growth of human leukemia cells by specific immunotoxins: nude mouse models.	Proc Natl Acad Sci U S A	1987	https://conductscience.org/library/papers/3494997	PubMed
3,110,351	Emergence of immunoglobulin variants following treatment of a B cell leukemia with an immunotoxin composed of antiidiotypic antibody and saporin.	J Exp Med	1987	https://conductscience.org/library/papers/3110351	PubMed
2,997,783	Targeting of loaded Sendai virus envelopes by covalently attached insulin molecules to virus receptor-depleted cells: fusion-mediated microinjection of ricin A and simian virus 40 DNA.	Proc Natl Acad Sci U S A	1985	https://conductscience.org/library/papers/2997783	PubMed
2,993,314	Selective destruction of nerve growth factor receptor-bearing cells in vitro using a hybrid toxin composed of ricin A chain and a monoclonal antibody against the nerve growth factor receptor.	J Cell Biol	1985	https://conductscience.org/library/papers/2993314	PubMed
2,081,785	Immunotoxins: new therapeutic reagents for autoimmunity, cancer, and AIDS.	J Clin Immunol	1990	https://conductscience.org/library/papers/2081785	PubMed
1,731,346	Treatment of premalignancy: prevention of lymphoma in radiation leukemia virus-inoculated mice by cyclosporin A and immunotoxin.	Proc Natl Acad Sci U S A	1992	https://conductscience.org/library/papers/1731346	PubMed

Show 8 more cited byShow fewer cited by

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

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ClinicalTrials.govNo license stated
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NIH RePORTER's grant and paper linksPublic domain
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PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

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NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
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