Paper68095
Cultured human monocytes synthesize and secrete alpha2-macroglobulin.
Hovi T and 2 others. J Exp Med, 1977. Cited by 225 papers, by iCite.
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ConductScience Library. Cultured human monocytes synthesize and secrete alpha2-macroglobulin. Papers, record 68095. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/68095
Paper
PubMed's record of the paper, with iCite's citation figures. No abstract is shown.
Topics11
NLM's MeSH indexing of the paper, its major topics first.
| MeSH term | Major |
|---|---|
| Monocytes | Major topic |
| alpha-Macroglobulins | Major topic |
| B-Lymphocytes | |
| Cells, Cultured | |
| Chemical Precipitation | |
| Electrophoresis, Polyacrylamide Gel | |
| Fluorescent Antibody Technique | |
| Humans | |
| Leukocytes | |
| Macrophages | |
| Peptides |
Source PubMed
References25
The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.
| Order | PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|---|
| 1 | 1,099,092 | Enhancement of migration inhibitory factor activity by plasma esterase inhibitors. | J Biol Chem | 1975 | https://conductscience.org/library/papers/1099092 | PubMed |
| 2 | 1,201,282 | Uptake of proteinase-alpha-macroglobulin complexes by macrophages. | Biochim Biophys Acta | 1975 | https://conductscience.org/library/papers/1201282 | PubMed |
| 4 | 14,074,395 | PLASMA PROTEIN FORMATION IN VITRO BY TISSUES FROM MICE INFECTED WITH STAPHYLOCOCCI. | J Exp Med | 1963 | https://conductscience.org/library/papers/14074395 | PubMed |
| 5 | 167,095 | Secretion of a specific collagenase by stimulated macrophages. | J Exp Med | 1975 | https://conductscience.org/library/papers/167095 | PubMed |
| 6 | 167,096 | Elastase secretion by stimulated macrophages. Characterization and regulation. | J Exp Med | 1975 | https://conductscience.org/library/papers/167096 | PubMed |
| 7 | 167,099 | Fibroblast surface antigen produced but not retained by virus-transformed human cells. | J Exp Med | 1975 | https://conductscience.org/library/papers/167099 | PubMed |
| 8 | 4,143,252 | Preliminary studies on the synthesis of alpha2-macroglobulin by human lymphocytes in vitro. | Clin Exp Immunol | 1974 | https://conductscience.org/library/papers/4143252 | PubMed |
| 9 | 4,201,304 | The interaction of alpha 2-macroglobulin with proteinases. Characteristics and specificity of the reaction, and a hypothesis concerning its molecular mechanism. | Biochem J | 1973 | https://conductscience.org/library/papers/4201304 | PubMed |
| 10 | 4,202,481 | Association of alpha-macroglobulins with lymphoid cells. | Nat New Biol | 1973 | https://conductscience.org/library/papers/4202481 | PubMed |
| 11 | 4,275,042 | Fixation of cell-bound antibody in the membrane immunofluorescence test. | J Immunol Methods | 1974 | https://conductscience.org/library/papers/4275042 | PubMed |
| 12 | 4,427,092 | Induction of macrophage plasminogen activator by endotoxin stimulation and phagocytosis: evidence for a two-stage process. | J Exp Med | 1974 | https://conductscience.org/library/papers/4427092 | PubMed |
| 13 | 4,587,740 | A rapid method for the isolation of functional thymus-derived murine lymphocytes. | Eur J Immunol | 1973 | https://conductscience.org/library/papers/4587740 | PubMed |
| 14 | 4,659,649 | Studies of radioiodinated fibrinogen. I. Physicochemical properties of the ICl, chloramine-T, and electrolytic reaction products. | Biochim Biophys Acta | 1972 | https://conductscience.org/library/papers/4659649 | PubMed |
| 15 | 47,865 | Normal and pathological serum levels of alpha2-macroglobulins in men and mice. | J Clin Pathol | 1975 | https://conductscience.org/library/papers/47865 | PubMed |
| 16 | 4,808,940 | Immune complexes induce selective release of lysosomal hydrolases from macrophages. | Nature | 1974 | https://conductscience.org/library/papers/4808940 | PubMed |
| 17 | 4,816,302 | Secretion of plasminogen activator by stimulated macrophages. | J Exp Med | 1974 | https://conductscience.org/library/papers/4816302 | PubMed |
| 18 | 4,960,195 | Separation of lymphocytes from human blood. | Acta Haematol | 1966 | https://conductscience.org/library/papers/4960195 | PubMed |
| 19 | 4,963,792 | Sites of synthesis of serum proteins. OI. Serum proteins produced by macrophages in vitro. | J Immunol | 1967 | https://conductscience.org/library/papers/4963792 | PubMed |
| 20 | 5,100,767 | Radioactive labeling of proteins in vitro. | J Biol Chem | 1971 | https://conductscience.org/library/papers/5100767 | PubMed |
| 21 | 5,411,979 | Stimulation of rabbit peripheral lymphocytes with antisera to alpha-macroglobulin. | Int Arch Allergy Appl Immunol | 1970 | https://conductscience.org/library/papers/5411979 | PubMed |
Cited by49
The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 225 citations.
| PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|
| 41,964,382 | Human α2-Macroglobulin: Architecture, Mechanisms, and Functional Implications. | FASEB J | 2026 | https://conductscience.org/library/papers/41964382 | PubMed |
| 25,045,023 | Phenotypic expression in human monocyte-derived interleukin-4-induced foreign body giant cells and macrophages in vitro: dependence on material surface properties. | J Biomed Mater Res A | 2015 | https://conductscience.org/library/papers/25045023 | PubMed |
| 21,883,963 | Contribution of murine innate serum inhibitors toward interference within influenza virus immune assays. | Influenza Other Respir Viruses | 2012 | https://conductscience.org/library/papers/21883963 | PubMed |
| 9,798,094 | Interaction of transforming growth factor-beta-1 with alpha-2-macroglobulin from normal and inflamed equine joints. | Can J Vet Res | 1998 | https://conductscience.org/library/papers/9798094 | PubMed |
| 8,973,565 | Proteinases are isoform-specific regulators of the binding of transforming growth factor beta to alpha 2-macroglobulin. | Biochem J | 1996 | https://conductscience.org/library/papers/8973565 | PubMed |
| 8,785,722 | Evaluation of plasma alpha-2-macroglobulin and interactions with tumour necrosis factor-alpha in horses with endotoxemic signs. | Can J Vet Res | 1996 | https://conductscience.org/library/papers/8785722 | PubMed |
| 8,225,567 | Effects of serine protease inhibitor, TAME, on IL-1 beta in LPS-stimulated human monocytes: relationship between synthesis and release of a 33-kDa precursor and the 17-kDa biologically active species. | Inflammation | 1993 | https://conductscience.org/library/papers/8225567 | PubMed |
| 7,851,015 | Secretion of immunoglobulins and plasma proteins from the colonic mucosa: an in vivo study in man. | Clin Exp Immunol | 1995 | https://conductscience.org/library/papers/7851015 | PubMed |
| 7,537,521 | Changes in tissue distribution of rat alpha 1-macroglobulin and pregnancy-associated alpha 1-glycoprotein after inflammatory injury. | Int J Exp Pathol | 1994 | https://conductscience.org/library/papers/7537521 | PubMed |
| 7,359,083 | Fibronectin is produced by human macrophages. | J Exp Med | 1980 | https://conductscience.org/library/papers/7359083 | PubMed |
| 7,251,858 | Cystic fibrosis ciliary dyskinesia substances and pulmonary disease. Effects of ciliary dyskinesia substances on neutrophil movement in vitro. | J Clin Invest | 1981 | https://conductscience.org/library/papers/7251858 | PubMed |
| 6,912,276 | Human monocyte spreading induced by factor Bb of the alternative pathway of complement activation. A possible role for C5 in monocyte spreading. | J Exp Med | 1981 | https://conductscience.org/library/papers/6912276 | PubMed |
| 6,803,512 | Localization of factor VIII/von Willebrand factor and glial fibrillary acidic protein in the hemangioblastoma: implications for stromal cell histogenesis. | Acta Neuropathol | 1982 | https://conductscience.org/library/papers/6803512 | PubMed |
| 6,746,905 | Secretion of immunoglobulins and plasma proteins from the jejunal mucosa. Transport rate and origin of polymeric immunoglobulin A. | J Clin Invest | 1984 | https://conductscience.org/library/papers/6746905 | PubMed |
| 6,424,942 | Cysteine proteinase inhibitors produced by mononuclear phagocytes. | Cell Tissue Res | 1984 | https://conductscience.org/library/papers/6424942 | PubMed |
| 6,409,477 | Acute phase serum proteins in syngeneic and allogeneic mouse pregnancy. | Clin Exp Immunol | 1983 | https://conductscience.org/library/papers/6409477 | PubMed |
| 6,376,293 | Macrophage activation, chronic inflammation and gastrointestinal disease. | Gut | 1984 | https://conductscience.org/library/papers/6376293 | PubMed |
| 6,360,889 | Production of macrophage activation factors by tryptic cleavage of calf serum proteins. | Inflammation | 1983 | https://conductscience.org/library/papers/6360889 | PubMed |
| 6,339,521 | Immunolocalization of a novel, cytoskeleton-associated polypeptide of Mr 230,000 daltons (p230). | J Cell Biol | 1983 | https://conductscience.org/library/papers/6339521 | PubMed |
| 6,209,408 | Heritable alpha 2-macroglobulin deficiency in a patient with arterial thrombosis: alpha 2-macroglobulin deficiency Irvine. | J Natl Med Assoc | 1984 | https://conductscience.org/library/papers/6209408 | PubMed |
Genes1
The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.
| Gene | NCBI Gene ID | Linked by | In Genes |
|---|---|---|---|
| A2M | 2 | PubTator's text mining | https://conductscience.org/library/genes/2 |
Source NCBI Gene
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- 2026-11-12
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- 2026-11-11
- Pipelines
- 2026-09-18
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- ClinicalTrials.govNo license stated
- HGNCCC0
- iCiteCC BY 4.0
- NCBI GenePublic domain (US government)
- NIH RePORTER's grant and paper linksPublic domain
- Open TargetsCC0 1.0
- PMC's ID filePublic domain (US government)
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
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- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
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- HGNCCC0: https://www.genenames.org/about/license/
- iCiteCC BY 4.0
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
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