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Paper · 6928643

Triplicated alpha-globin loci in humans.

Goossens M and 6 others. Proc Natl Acad Sci U S A, 1980. Cited by 246 papers, by iCite.

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ConductScience Library. Triplicated alpha-globin loci in humans. Papers, record 6928643. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/6928643

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Triplicated alpha-globin loci in humans.
PubMed
Journal
Proc Natl Acad Sci U S A
PubMed
Year
1980
PubMed
Publication types
Journal Article, Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
246
iCite
Relative citation ratio, by iCite
5.53
iCite
Revised in PubMed
2022-12-07
PubMed

Authors7

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Goossens MM
2Dozy AMA M
3Embury SHS H
4Zachariades ZZ
5Hadjiminas MGM G
6Stamatoyannopoulos GG
7Kan YWY W

Source PubMed

Topics9

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
GenesMajor topic
GlobinsMajor topic
Black People
Cyprus
Gene Frequency
Genetic Linkage
Hemoglobin A
Humans
Recombination, Genetic

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References22

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
15,775,343Globin chain synthesis in the alpha thalassemia syndromes.J Clin Invest1969https://conductscience.org/library/papers/5775343PubMed
213,968,954The fusion of two peptide chains in hemoglobin Lepore and its interpretation as a genetic deletion.Proc Natl Acad Sci U S A1962https://conductscience.org/library/papers/13968954PubMed
35,492,814Observations on haemoglobin P (Congo type).Biochem J1970https://conductscience.org/library/papers/5492814PubMed
45,288,810Haemoglobin Miyada, a beta-delta fusion peptide (anti-Lepore) type discovered in a Japanese family.Nat New Biol1971https://conductscience.org/library/papers/5288810PubMed
54,654,161Duplication of haemoglobin genes.Biochimie1972https://conductscience.org/library/papers/4654161PubMed
64,513,408Haemoglobin P-Nilotic containing a - chain.Nat New Biol1973https://conductscience.org/library/papers/4513408PubMed
74,138,824The severe form of alpha thalassaemia is caused by a haemoglobin gene deletion.Nature1974https://conductscience.org/library/papers/4138824PubMed
84,424,635Genetic lesion in homozygous alpha thalassaemia (hydrops fetalis).Nature1974https://conductscience.org/library/papers/4424635PubMed
91,170,497Deletion of alpha-globin genes in haemoglobin-H disease demonstrates multiple alpha-globin structural loci.Nature1975https://conductscience.org/library/papers/1170497PubMed
10561,664Localization of the human alpha-globin structural gene to chromosome 16 in somatic cell hybrids by molecular hybridization assay.Cell1977https://conductscience.org/library/papers/561664PubMed

1 to 10 of 22

See all 22 references

Cited by79

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 246 citations.

PMIDTitleJournalYearIn PapersSource
40,176,065Application value of long-read sequencing in full characterization of thalassemia-associated structural variations: identifying a novel large segmental duplication and literature review.Orphanet J Rare Dis2025https://conductscience.org/library/papers/40176065PubMed
39,600,315Genetic screening of α-thalassemia fusion gene using routine flow-through hybridization.Front Genet2024https://conductscience.org/library/papers/39600315PubMed
37,928,241Prevalence and genetic analysis of triplicated α-globin gene in Ganzhou region using high-throughput sequencing.Front Genet2023https://conductscience.org/library/papers/37928241PubMed
36,766,477Next-Generation Sequencing (NGS) and Third-Generation Sequencing (TGS) for the Diagnosis of Thalassemia.Diagnostics (Basel)2023https://conductscience.org/library/papers/36766477PubMed
36,074,711The hemoglobinopathies, molecular disease mechanisms and diagnostics.Int J Lab Hematol2022https://conductscience.org/library/papers/36074711PubMed
35,834,496Alpha globin gene copy number and hypertension risk among Black Americans.PLoS One2022https://conductscience.org/library/papers/35834496PubMed
33,827,577Prevalence and clinical phenotype of the triplicated α-globin genes and its ethnic and geographical distribution in Guizhou of China.BMC Med Genomics2021https://conductscience.org/library/papers/33827577PubMed
28,276,593Association between sickle cell anemia and alpha thalassemia reveals a high prevalence of the α3.7 triplication in congolese patients than in worldwide series.J Clin Lab Anal2018https://conductscience.org/library/papers/28276593PubMed
27,408,425The Frequency of α-Globin Gene Triplication in a Southern Chinese Population.Indian J Hematol Blood Transfus2016https://conductscience.org/library/papers/27408425PubMed
27,199,182The molecular spectrum and distribution of haemoglobinopathies in Cyprus: a 20-year retrospective study.Sci Rep2016https://conductscience.org/library/papers/27199182PubMed

1 to 10 of 79

See all 79 cited by

Genes4

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
ADCY1055,811PubTator's text mininghttps://conductscience.org/library/genes/55811NCBI Gene
HBA23,040PubTator's text mininghttps://conductscience.org/library/genes/3040NCBI Gene
LOC106804612106,804,612PubTator's text mininghttps://conductscience.org/library/genes/106804612NCBI Gene
LOC106804613106,804,613PubTator's text mininghttps://conductscience.org/library/genes/106804613NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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