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Paper · 6974741

Tumor promoter phorbol myristic acetate stimulates immunoglobulin secretion correlated with growth cessation in human B lymphocyte cell lines.

Ralph P and 1 other. J Clin Invest, 1981. Cited by 48 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Tumor promoter phorbol myristic acetate stimulates immunoglobulin secretion correlated with growth cessation in human B lymphocyte cell lines. Papers, record 6974741. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/6974741

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Tumor promoter phorbol myristic acetate stimulates immunoglobulin secretion correlated with growth cessation in human B lymphocyte cell lines.
PubMed
Journal
J Clin Invest
PubMed
Year
1981
PubMed
Publication types
Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
48
iCite
Relative citation ratio, by iCite
1.35
iCite
Revised in PubMed
2019-06-06
PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Ralph PP
2Kishimoto TT

Source PubMed

Topics9

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
B-LymphocytesMajor topic
ImmunoglobulinsMajor topic
PhorbolsMajor topic
Tetradecanoylphorbol AcetateMajor topic
Antibody Formation
Cell Differentiation
Cell Division
Cell Line
Humans

Source PubMed

Grants1

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated by
CA 24300NCI NIH HHSUnited StatesR01CA024300PubMed and NIH

Source NIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References21

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
1593,321Inhibition of adipose conversion of 3T3 fibroblasts by tumour promoters.Nature1977https://conductscience.org/library/papers/593321PubMed
2305,004Induction of IgG production in human B lymphoblastoid cell lines with normal human T cells.Nature1978https://conductscience.org/library/papers/305004PubMed
3308,698Tumor-promoting phorbol esters inhibit binding of epidermal growth factor to cellular receptors.Science1978https://conductscience.org/library/papers/308698PubMed
46,967,217Phorbol esters induce differentiation in human malignant T lymphoblasts.Proc Natl Acad Sci U S A1980https://conductscience.org/library/papers/6967217PubMed
5269,404Tumor promoters inhibit spontaneous and induced differentiation of murine erythroleukemia cells in culture.Proc Natl Acad Sci U S A1977https://conductscience.org/library/papers/269404PubMed
66,253,086T-Cell regulation of B-lymphoblastoid cell line function.Cell Immunol1980https://conductscience.org/library/papers/6253086PubMed
7958,393Phorbol esters stimulate DNA synthesis and ornithine decarboxylase activity in mouse epidermal cell cultures.Nature1976https://conductscience.org/library/papers/958393PubMed
8313,946In vitro immune response of human peripheral lymphocytes. IV. Specific induction of human suppressor T cells by an antiserum to the T leukemia cell line HSB.J Immunol1979https://conductscience.org/library/papers/313946PubMed
9566,614Establishment of a human plasma cell line in vitro.Cancer Res1978https://conductscience.org/library/papers/566614PubMed
10291,929Regulation of normal differentiation in mouse and human myeloid leukemic cells by phorbol esters and the mechanism of tumor promotion.Proc Natl Acad Sci U S A1979https://conductscience.org/library/papers/291929PubMed

1 to 10 of 21

See all 21 references

Cited by6

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 48 citations.

PMIDTitleJournalYearIn PapersSource
6,611,34812-O-Tetradecanoylphorbol-13-acetate (TPA) directly inhibits spontaneous immunoglobulin secretion by in vivo antigen-induced human lymphoblastoid B cells.J Clin Immunol1984https://conductscience.org/library/papers/6611348PubMed
6,604,057Stimulation of cell proliferation by tumor-promoting phorbol esters and inhibition by some inhibitors of tumor promotion in suspension cultures of a human lymphoblastoid cell line.J Cancer Res Clin Oncol1983https://conductscience.org/library/papers/6604057PubMed
6,087,121Human monoclonal antibodies.Mol Cell Biochem1984https://conductscience.org/library/papers/6087121PubMed
3,878,751Influence of TPA (12-O-tetradodecanoyl-phorbol-13-acetate) on human B lymphocyte function.Clin Exp Immunol1985https://conductscience.org/library/papers/3878751PubMed
3,872,753Phorbol ester-induced differentiation of chronic B lymphocytic leukaemia cells--regulatory impact of autologous and allogeneic accessory cells.Clin Exp Immunol1985https://conductscience.org/library/papers/3872753PubMed
2,986,115Specific expression of the human cellular fps/fes-encoded protein NCP92 in normal and leukemic myeloid cells.Proc Natl Acad Sci U S A1985https://conductscience.org/library/papers/2986115PubMed

Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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