Paper · 7011990

Protective effect of immunization of rats with holotoxin or B subunit of Escherichia coli heat-labile enterotoxin.

Klipstein FA and 1 other. Infect Immun, 1981. Cited by 23 papers, by iCite.

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ConductScience Library. Protective effect of immunization of rats with holotoxin or B subunit of Escherichia coli heat-labile enterotoxin. Papers, record 7011990. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/7011990

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Protective effect of immunization of rats with holotoxin or B subunit of Escherichia coli heat-labile enterotoxin.; PubMed
Journal: Infect Immun; PubMed
Year: 1981; PubMed
Publication types: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/7011990/; PubMed
DOI: https://doi.org/10.1128/iai.31.1.144-150.1981; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC351763/; PubMed
The journal: https://conductscience.org/library/journal-index/0246127; PubMed
Citations, by iCite: 23; iCite
Relative citation ratio, by iCite: 0.91; iCite
Revised in PubMed: 2021-12-16; PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	Kind	ORCID iD
1	Klipstein FA	F A
2	Engert RF	R F

Source PubMed

Topics10

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Antitoxins	Major topic
Bacterial Toxins	Major topic
Enterotoxins	Major topic
Escherichia coli	Major topic
Escherichia coli Proteins	Major topic
Immunization	Major topic
Animals
Dose-Response Relationship, Immunologic
Hot Temperature
Rats

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References38

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	7,380,543	Antitoxic immunity to cholera in dogs immunized orally with cholera toxin.	Infect Immun	1980	https://conductscience.org/library/papers/7380543	PubMed
2	399,324	The molecular nature of heat-labile enterotoxin (LT) of escherichia coli.	Nature	1979	https://conductscience.org/library/papers/399324	PubMed
3	1,238,506	Cellular kinetics of the intestinal immune response to cholera toxoid in rats.	J Exp Med	1975	https://conductscience.org/library/papers/1238506	PubMed
4	54,337	Antitoxic immunity in experimental cholera: protection, and serum and local antibody responses in rabbits after enteral and parenteral immunization.	Infect Immun	1975	https://conductscience.org/library/papers/54337	PubMed
5	16,558,081	Polymyxin B-Induced Release of Low-Molecular-Weight, Heat-Labile Enterotoxin from Escherichia coli.	Infect Immun	1974	https://conductscience.org/library/papers/16558081	PubMed
6	336,542	Protection against challenge with Escherichia coli heat-labile enterotoxin by immunization of rats with cholera toxin/toxoid.	Infect Immun	1977	https://conductscience.org/library/papers/336542	PubMed
7	6,988,518	Adenosine diphosphate-ribosylation of adenylate cyclase catalyzed by heat-labile enterotoxin of Escherichia coli: comparison with cholera toxin.	J Infect Dis	1980	https://conductscience.org/library/papers/6988518	PubMed
8	992,868	Immunological control mechanism against cholera toxin: interference with toxin binding to intestinal receptors.	Infect Immun	1976	https://conductscience.org/library/papers/992868	PubMed
9	4,664,117	Protection against experimental cholera by antitoxin.	J Infect Dis	1972	https://conductscience.org/library/papers/4664117	PubMed
10	6,156,914	Properties of homogeneous heat-labile enterotoxin from Escherichia coli.	Infect Immun	1980	https://conductscience.org/library/papers/6156914	PubMed

1 to 10 of 38

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Cited by13

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 23 citations.

PMID	Title	Journal	Year	In Papers	Source
7,129,629	Arousal of mucosal secretory immunoglobulin A antitoxin in rats immunized with Escherichia coli heat-labile enterotoxin.	Infect Immun	1982	https://conductscience.org/library/papers/7129629	PubMed
7,030,964	Protection in rats immunized with Escherichia coli heat-stable enterotoxin.	Infect Immun	1981	https://conductscience.org/library/papers/7030964	PubMed
7,019,087	Immunization of rats with heat-labile enterotoxin provides uniform protection against heterologous serotypes of enterotoxigenic Escherichia coli.	Infect Immun	1981	https://conductscience.org/library/papers/7019087	PubMed
6,749,682	Development of a vaccine of cross-linked heat-stable and heat-labile enterotoxins that protects against Escherichia coli producing either enterotoxin.	Infect Immun	1982	https://conductscience.org/library/papers/6749682	PubMed
6,746,090	Properties of crude Campylobacter jejuni heat-labile enterotoxin.	Infect Immun	1984	https://conductscience.org/library/papers/6746090	PubMed
6,682,834	Protection in rabbits immunized with a vaccine of Escherichia coli heat-stable toxin cross-linked to the heat-labile toxin B subunit.	Infect Immun	1983	https://conductscience.org/library/papers/6682834	PubMed
6,365,784	Differences in cross-protection in rats immunized with the B subunits of cholera toxin and Escherichia coli heat-labile toxin.	Infect Immun	1984	https://conductscience.org/library/papers/6365784	PubMed
6,363,898	New knowledge on pathogenesis of bacterial enteric infections as applied to vaccine development.	Microbiol Rev	1983	https://conductscience.org/library/papers/6363898	PubMed
6,352,492	Effect of parenteral immunization on the local immunoglobulin A response of the intestine to Shigella flexneri antigens.	Infect Immun	1983	https://conductscience.org/library/papers/6352492	PubMed
6,343,245	Protection against human and porcine enterotoxigenic strains of Escherichia coli in rats immunized with a cross-linked toxoid vaccine.	Infect Immun	1983	https://conductscience.org/library/papers/6343245	PubMed

1 to 10 of 13

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Genes0

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None in this release.

Drugs0

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None in this release.

Data0

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None in this release.

Data dates

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PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

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ClinicalTrials.govNo license stated
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iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

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ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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