ConductScience.org, home

Paper · 70310

The interplay of evolution and environment in B-cell diversification.

Klinman NR and 4 others. Cold Spring Harb Symp Quant Biol, 1977. Cited by 27 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

Download JSON
Cite this record

ConductScience Library. The interplay of evolution and environment in B-cell diversification. Papers, record 70310. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/70310

On this page

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
The interplay of evolution and environment in B-cell diversification.
PubMed
Journal
Cold Spring Harb Symp Quant Biol
PubMed
Year
1977
PubMed
Publication types
Journal Article, Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
27
iCite
Relative citation ratio, by iCite
0.54
iCite
Revised in PubMed
2019-08-23
PubMed

Authors5

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Klinman NRN R
2Sigal NHN H
3Metcalf ESE S
4Pierce SKS K
5Gearhart PJP J

Source PubMed

Topics21

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
B-LymphocytesMajor topic
Biological EvolutionMajor topic
Age Factors
Animals
Animals, Newborn
Antibody Specificity
Antigens
Bone Marrow
Bone Marrow Cells
Carrier Proteins
Clone Cells
Environment
Epitopes
Germ-Free Life
Haptens
Immune Tolerance
Immunologic Memory
Mice
Selection, Genetic
Spleen
T-Lymphocytes

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References0

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

None in this release.

Cited by8

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 27 citations.

PMIDTitleJournalYearIn PapersSource
9,406,350DNA vaccines: safety and efficacy issues.Springer Semin Immunopathol1997https://conductscience.org/library/papers/9406350PubMed
8,981,914Induction of neonatal tolerance by plasmid DNA vaccination of mice.J Clin Invest1996https://conductscience.org/library/papers/8981914PubMed
6,172,364Hybridomas: a new dimension in biological analyses.In Vitro1981https://conductscience.org/library/papers/6172364PubMed
3,899,707The adaptive significance of sexuality.Experientia1985https://conductscience.org/library/papers/3899707PubMed
3,495,004Clonal analysis of the anti-DNA repertoire of murine B lymphocytes.Proc Natl Acad Sci U S A1987https://conductscience.org/library/papers/3495004PubMed
374,264
Ontogeny of B-lymphocyte function. IX. Difference in the time of maturation of the capacity of B lymphocytes from foetal and neonatal mice to produce a heterogeneous antibody response to thymic-dependent and thymic-independent antigens.
Immunology1979https://conductscience.org/library/papers/374264PubMed
303,683Role of IgD in the immune response and tolerance. I. Anti-delta pretreatment facilitates tolerance induction in adult B cells in vitro.J Exp Med1977https://conductscience.org/library/papers/303683PubMed
92,194Monoclonal antibodies. Hybrid myelomas--a revolution in serology and immunogenetics.Am J Hum Genet1979https://conductscience.org/library/papers/92194PubMed

Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this paper from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/papers/v1/70310

GET https://conductscience.org/api/papers/v1/70310/authors