Paper · 303683

Role of IgD in the immune response and tolerance. I. Anti-delta pretreatment facilitates tolerance induction in adult B cells in vitro.

Scott DW and 2 others. J Exp Med, 1977. Cited by 119 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

Cite this record

ConductScience Library. Role of IgD in the immune response and tolerance. I. Anti-delta pretreatment facilitates tolerance induction in adult B cells in vitro. Papers, record 303683. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/303683

On this page

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Role of IgD in the immune response and tolerance. I. Anti-delta pretreatment facilitates tolerance induction in adult B cells in vitro.; PubMed
Journal: J Exp Med; PubMed
Year: 1977; PubMed
Publication types: Journal Article, Research Support, U.S. Gov't, P.H.S.; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/303683/; PubMed
DOI: https://doi.org/10.1084/jem.146.6.1473; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC2181910/; PubMed
The journal: https://conductscience.org/library/journal-index/2985109R; PubMed
Citations, by iCite: 119; iCite
Relative citation ratio, by iCite: 2.34; iCite
Revised in PubMed: 2019-05-08; PubMed

Authors3

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Scott DW	D W
2	Layton JE	J E
3	Nossal GJ	G J

Source PubMed

Topics9

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Antibody Formation	Major topic
Immune Tolerance	Major topic
Immunoglobulin D	Major topic
Animals
B-Lymphocytes
Clone Cells
Immune Sera
Mice
Spleen

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References23

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	95,788	B-cell tolerance. II. Trinitrophenyl human gamma globulin-induced tolerance in adult and neonatal murine B cells responsive to thymus-dependent and independent forms of the same hapten.	J Exp Med	1977	https://conductscience.org/library/papers/95788	PubMed
2	70,310	The interplay of evolution and environment in B-cell diversification.	Cold Spring Harb Symp Quant Biol	1977	https://conductscience.org/library/papers/70310	PubMed
3	66,197	Tolerance induction in maturing B cells.	Immunology	1977	https://conductscience.org/library/papers/66197	PubMed
4	68,987	B-cell tolerance. III. Effect of papain-mediated cleavage of cell surface IgD on tolerance susceptibility of murine B cells.	J Exp Med	1977	https://conductscience.org/library/papers/68987	PubMed
5	67,178	In vitro tolerance induction of neonatal murine B cells as a probe for the study of B-cell diversification.	J Exp Med	1977	https://conductscience.org/library/papers/67178	PubMed
6	405,223	Mouse immunoglobulin receptors on lymphocytes: identification of IgM and IgD molecules by tryptic cleavage and a postulated role for cell surface IgD.	Eur J Immunol	1977	https://conductscience.org/library/papers/405223	PubMed
7	321,138	Hapten-IgG-induced suppression of the in vitro antibody response: role of hapten density and of antigenic challenge.	Cell Immunol	1977	https://conductscience.org/library/papers/321138	PubMed
8	796,385	Conjugation of antibodies with fluorochromes: modifications to the standard methods.	J Immunol Methods	1976	https://conductscience.org/library/papers/796385	PubMed
9	1,087,317	Cell surface immunoglobulin. XIX. Susceptibility of IgD and IgM on murine splenocytes to cleavage by papain.	J Immunol	1976	https://conductscience.org/library/papers/1087317	PubMed
10	4,103,329	Reversible blocking effect of anti-mouse immunoglobulin serum on the induction of immunity and tolerance in vitro.	Nat New Biol	1971	https://conductscience.org/library/papers/4103329	PubMed

1 to 10 of 23

See all 23 references

Cited by21

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 119 citations.

PMID	Title	Journal	Year	In Papers	Source
10,702,483	Immunoglobulin D: properties, measurement, and clinical relevance.	Clin Diagn Lab Immunol	2000	https://conductscience.org/library/papers/10702483	PubMed
8,902,576	Use of isolated immature-stage B cells to understand negative selection and tolerance induction at the molecular level.	Immunol Res	1996	https://conductscience.org/library/papers/8902576	PubMed
8,418,208	Immunoglobulin D (IgD)-deficient mice reveal an auxiliary receptor function for IgD in antigen-mediated recruitment of B cells.	J Exp Med	1993	https://conductscience.org/library/papers/8418208	PubMed
7,836,908	Cross-linking of membrane immunoglobulin D, in the absence of T cell help, kills mature B cells in vivo.	J Exp Med	1995	https://conductscience.org/library/papers/7836908	PubMed
6,972,997	Interactions between lymphocyte membrane molecules. I. Interaction between B lymphocyte surface IgM and Fc IgG receptors requires ligand occupancy of both receptors.	J Exp Med	1981	https://conductscience.org/library/papers/6972997	PubMed
6,967,945	Augmentation of in vitro humoral immune responses in the mouse by an antibody to IgD.	J Exp Med	1980	https://conductscience.org/library/papers/6967945	PubMed
6,784,124	Mouse immunoglobulin D: construction and characterization of a cloned delta chain cDNA.	Proc Natl Acad Sci U S A	1980	https://conductscience.org/library/papers/6784124	PubMed
6,609,402	Function of IgD in B cell triggering and tolerance: an overview of recent advances.	Surv Immunol Res	1984	https://conductscience.org/library/papers/6609402	PubMed
6,337,091	The expression of surface IgD on B cells responsive to thymus-independent and thymus-dependent antigens and its requirement for B-cell triggering.	Immunology	1983	https://conductscience.org/library/papers/6337091	PubMed
6,166,703	In vitro tolerance induction of primed, IgD-negative murine spleen cells.	J Exp Med	1981	https://conductscience.org/library/papers/6166703	PubMed

1 to 10 of 21

See all 21 cited by

Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this paper from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/papers/v1/303683

GET https://conductscience.org/api/papers/v1/303683/references?page=2

API reference For AI assistants