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Paper · 68987

B-cell tolerance. III. Effect of papain-mediated cleavage of cell surface IgD on tolerance susceptibility of murine B cells.

Cambier JC and 4 others. J Exp Med, 1977. Cited by 118 papers, by iCite.

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ConductScience Library. B-cell tolerance. III. Effect of papain-mediated cleavage of cell surface IgD on tolerance susceptibility of murine B cells. Papers, record 68987. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/68987

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
B-cell tolerance. III. Effect of papain-mediated cleavage of cell surface IgD on tolerance susceptibility of murine B cells.
PubMed
Journal
J Exp Med
PubMed
Year
1977
PubMed
Publication types
Journal Article, Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
118
iCite
Relative citation ratio, by iCite
2.3
iCite
Revised in PubMed
2019-05-08
PubMed

Authors5

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Cambier JCJ C
2Vitetta ESE S
3Kettman JRJ R
4Wetzel GMG M
5Uhr JWJ W

Source PubMed

Topics20

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
B-LymphocytesMajor topic
Immune ToleranceMajor topic
Immunoglobulin DMajor topic
PapainMajor topic
Animals
Cell Membrane
Erythrocytes
Female
Histocompatibility Antigens
Male
Mice
Mice, Inbred C57BL
Mice, Inbred DBA
Protein Biosynthesis
Receptors, Antigen, B-Cell
Sheep
Spleen
Thymus Gland
Trinitrobenzenesulfonic Acid
gamma-Globulins

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References23

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
147,889Evidence for the clonal abortion theory of B-lymphocyte tolerance.J Exp Med1975https://conductscience.org/library/papers/47889PubMed
258,052In vitro tolerance induction of neonatal murine B cells.J Exp Med1976https://conductscience.org/library/papers/58052PubMed
395,788B-cell tolerance. II. Trinitrophenyl human gamma globulin-induced tolerance in adult and neonatal murine B cells responsive to thymus-dependent and independent forms of the same hapten.J Exp Med1977https://conductscience.org/library/papers/95788PubMed
4299,767B-lymphocyte heterogeneity: development and characterization of an alloantiserum which distinguishes B-lymphocyte differentiation alloantigens.J Exp Med1977https://conductscience.org/library/papers/299767PubMed
5811,748Differences in susceptibility of mature and immature mouse B lymphocytes to anti-immunoglobulin-induced immunoglobulin suppression in vitro. Possible implications for B-cell tolerance to self.J Exp Med1975https://conductscience.org/library/papers/811748PubMed
61,063,411Genetic polymorphism of IgD-like cell surface immunoglobulin in the mouse.Proc Natl Acad Sci U S A1976https://conductscience.org/library/papers/1063411PubMed
71,084,409Differential susceptibility of neonatal and adult murine spleen cells to in vitro induction of B-cell tolerance.J Exp Med1976https://conductscience.org/library/papers/1084409PubMed
81,084,996Ontogeny of mouse B lymphocytes and inactivation by antigen of early B lymphocytes.Proc Natl Acad Sci U S A1976https://conductscience.org/library/papers/1084996PubMed
91,085,326Murine B-cell subpopulations responsive to T-dependent and T-independent antigens.J Exp Med1976https://conductscience.org/library/papers/1085326PubMed
101,087,317Cell surface immunoglobulin. XIX. Susceptibility of IgD and IgM on murine splenocytes to cleavage by papain.J Immunol1976https://conductscience.org/library/papers/1087317PubMed

1 to 10 of 23

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Cited by27

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 118 citations.

PMIDTitleJournalYearIn PapersSource
42,840,352B cells in the retinal pigment epithelium change with aging and IgM availability.iScience2026https://conductscience.org/library/papers/42840352PubMed
39,994,686Secreted IgM deficiency alters the retinal landscape enhancing neurodegeneration associated with aging.Immun Ageing2025https://conductscience.org/library/papers/39994686PubMed
31,259,891Isolation and Quantitative Evaluation of Brush Cells from Mouse Tracheas.J Vis Exp2019https://conductscience.org/library/papers/31259891PubMed
24,368,810Filamentous morphology of bacteria delays the timing of phagosome morphogenesis in macrophages.J Cell Biol2013https://conductscience.org/library/papers/24368810PubMed
12,383,202Role of stromal-cell derived factor-1 in the development of autoimmune diseases in non-obese diabetic mice.Immunology2002https://conductscience.org/library/papers/12383202PubMed
9,479,577Antigen receptor-initiated signals for B cell development and selection.Immunol Res1998https://conductscience.org/library/papers/9479577PubMed
8,902,576Use of isolated immature-stage B cells to understand negative selection and tolerance induction at the molecular level.Immunol Res1996https://conductscience.org/library/papers/8902576PubMed
8,446,604Immunoglobulin D-deficient mice can mount normal immune responses to thymus-independent and -dependent antigens.Proc Natl Acad Sci U S A1993https://conductscience.org/library/papers/8446604PubMed
8,418,208Immunoglobulin D (IgD)-deficient mice reveal an auxiliary receptor function for IgD in antigen-mediated recruitment of B cells.J Exp Med1993https://conductscience.org/library/papers/8418208PubMed
8,070,406The IgM antigen receptor of B lymphocytes is associated with prohibitin and a prohibitin-related protein.EMBO J1994https://conductscience.org/library/papers/8070406PubMed

1 to 10 of 27

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Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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