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Paper · 67178

In vitro tolerance induction of neonatal murine B cells as a probe for the study of B-cell diversification.

Metcalf ES and 2 others. J Exp Med, 1977. Cited by 25 papers, by iCite.

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ConductScience Library. In vitro tolerance induction of neonatal murine B cells as a probe for the study of B-cell diversification. Papers, record 67178. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/67178

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
In vitro tolerance induction of neonatal murine B cells as a probe for the study of B-cell diversification.
PubMed
Journal
J Exp Med
PubMed
Year
1977
PubMed
Publication types
Journal Article, Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
25
iCite
Relative citation ratio, by iCite
0.47
iCite
Revised in PubMed
2019-05-08
PubMed

Authors3

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Metcalf ESE S
2Sigal NHN H
3Klinman NRN R

Source PubMed

Topics15

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Animals, NewbornMajor topic
B-LymphocytesMajor topic
Cell DifferentiationMajor topic
Immune ToleranceMajor topic
Animals
Antibody Specificity
Antigens
Dinitrobenzenes
Hemocyanins
Immunization, Passive
Mice
Mice, Inbred BALB C
Phosphorylcholine
Radioimmunoassay
gamma-Globulins

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References9

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
11,078,833The frequency of phosphorylcholine-specific B cells in conventional and germfree BALB/C mice.J Immunol1975https://conductscience.org/library/papers/1078833PubMed
21,084,411Ontogeny of B cells in the chicken. I. Sequential development of clonal diversity in the bursa.J Exp Med1976https://conductscience.org/library/papers/1084411PubMed
34,109,646The take-home lesson--1971.Ann N Y Acad Sci1971https://conductscience.org/library/papers/4109646PubMed
44,114,497The mechanism of antigenic stimulation of primary and secondary clonal precursor cells.J Exp Med1972https://conductscience.org/library/papers/4114497PubMed
54,190,985Mechanism of antibody diversity: germ line basis for variability.Science1970https://conductscience.org/library/papers/4190985PubMed
64,591,829Coupling of large haptens to proteins and cell surfaces: preparation of stable, optimally sensitized erythrocytes for hapten-specific, hemolytic plaque assays.Immunochemistry1973https://conductscience.org/library/papers/4591829PubMed
747,895The characterization fo the B-cell repertoire specific for the 2,4-dinitrophenyl and 2,4,6-trinitrophenyl determinants in neonatal BALB/c mice.J Exp Med1975https://conductscience.org/library/papers/47895PubMed
858,052In vitro tolerance induction of neonatal murine B cells.J Exp Med1976https://conductscience.org/library/papers/58052PubMed
960,906Assessing B cell diversification by antigen receptor and precursor cell analysis.Ann Immunol (Paris)1976https://conductscience.org/library/papers/60906PubMed

Cited by3

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 25 citations.

PMIDTitleJournalYearIn PapersSource
6,601,176Genetic and temporal control of neonatal antibody expression.J Exp Med1983https://conductscience.org/library/papers/6601176PubMed
303,683Role of IgD in the immune response and tolerance. I. Anti-delta pretreatment facilitates tolerance induction in adult B cells in vitro.J Exp Med1977https://conductscience.org/library/papers/303683PubMed
302,315Expression of phosphorylcholine-specific B cells during murine development.J Exp Med1977https://conductscience.org/library/papers/302315PubMed

Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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