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Antigen-specific T-cell-mediated suppression. I. Induction of L-glutamic acid60-L-alanine30-L-tyrosine10 specific suppressor T cells in vitro requires both antigen-specific T-cell-suppressor factor and antigen.

Germain RN and 3 others. J Exp Med, 1978. Cited by 93 papers, by iCite.

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ConductScience Library. Antigen-specific T-cell-mediated suppression. I. Induction of L-glutamic acid60-L-alanine30-L-tyrosine10 specific suppressor T cells in vitro requires both antigen-specific T-cell-suppressor factor and antigen. Papers, record 75231. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/75231

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Antigen-specific T-cell-mediated suppression. I. Induction of L-glutamic acid60-L-alanine30-L-tyrosine10 specific suppressor T cells in vitro requires both antigen-specific T-cell-suppressor factor and antigen.
PubMed
Journal
J Exp Med
PubMed
Year
1978
PubMed
Publication types
Journal Article, Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
93
iCite
Relative citation ratio, by iCite
1.98
iCite
Revised in PubMed
2021-12-03
PubMed

Authors4

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Germain RNR N
2Thèze JJ
3Kapp JAJ A
4Benacerraf BB

Source PubMed

Topics12

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Immunosuppression TherapyMajor topic
PeptidesMajor topic
T-LymphocytesMajor topic
Animals
Antigens
Cells, Cultured
Epitopes
H-2 Antigens
Macromolecular Substances
Mice
Mice, Inbred DBA
Spleen

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References32

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
11,081,576Properties of antigen-specific suppressive T-cell factor in the regulation of antibody response of the mouse. I. In vivo activity and immunochemical characterization.J Exp Med1975https://conductscience.org/library/papers/1081576PubMed
21,084,407Genetic control of specific immune suppression. IV. Responsiveness to the random copolymer L-glutamic acid50-L-tyrosine50 induced in BALB/c mice by cyclophosphamide.J Exp Med1976https://conductscience.org/library/papers/1084407PubMed
31,085,324T-cell regulation of antibody responses: demonstration of allotype-specific helper T cells and their specific removal by suppressor T cells.J Exp Med1976https://conductscience.org/library/papers/1085324PubMed
41,085,338A new I subregion (I-J) marked by a locus (Ia-4) controlling surface determinants on suppressor T lymphocytes.J Exp Med1976https://conductscience.org/library/papers/1085338PubMed
51,085,339
Properties of the antigen-specific suppressive T-cell factor in the regulation of antibody response of the mouse. IV. Special subregion assignment of the gene(s) that codes for the suppressive T-cell factor in the H-2 histocompatibility complex.
J Exp Med1976https://conductscience.org/library/papers/1085339PubMed
61,086,779Suppressor cell induction in vitro. II. Cellular requirements of suppressor cell induction.Eur J Immunol1976https://conductscience.org/library/papers/1086779PubMed
71,101,468Properties of primed suppressor T cells and their products.Transplant Rev1975https://conductscience.org/library/papers/1101468PubMed
8300,776
Immunosuppressive factor(s) extracted from lymphoid cells of nonresponder mice primed with L-glutamic acid60-L-alanine30-L-tyrosine10 (GAT) II. Cellular source and effect on responder and nonresponder mice.
J Exp Med1977https://conductscience.org/library/papers/300776PubMed
9302,186Suppressive and enhancing T-cell factors as I-region gene products: properties and the subregion assignment.Cold Spring Harb Symp Quant Biol1977https://conductscience.org/library/papers/302186PubMed
10302,317Immunosuppressive factor(s) specific for L-glutamic acid50-L-tyrosine50 (GT). III. Generation of suppressor T cells by a suppressive extract derived from GT-primed lymphoid cells.J Exp Med1977https://conductscience.org/library/papers/302317PubMed

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Cited by30

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 93 citations.

PMIDTitleJournalYearIn PapersSource
7,007,212Partial characterization of murine and monkey helper factor to a streptococcal antigen.Immunology1980https://conductscience.org/library/papers/7007212PubMed
6,966,320Selective suppression of the major idiotypic component of an antihapten response by soluble T cell-derived factors with idiotypic or anti-idiotypic receptors.J Exp Med1980https://conductscience.org/library/papers/6966320PubMed
6,792,727Helper and suppressor T cell factors.Springer Semin Immunopathol1980https://conductscience.org/library/papers/6792727PubMed
6,766,980Cellular consequences in the suppression of antibody response by the antigen-specific T-cell factor.J Exp Med1980https://conductscience.org/library/papers/6766980PubMed
6,606,014
Antigen-specific suppressor T cell interactions. II. Characterization of two different types of suppressor T cell factors specific for L-glutamic acid50-L-tyrosine50 (GT) and L-glutamic acid60-L-alanine30-L-tyrosine10 (GAT).
J Exp Med1983https://conductscience.org/library/papers/6606014PubMed
6,459,996
Regulation of the human allogenic proliferative response in vitro. II. Production of soluble suppressor factors by suppressor T cells and evidence in favor of "acceptor" cells for suppression among unprimed lymphocytes.
Immunogenetics1981https://conductscience.org/library/papers/6459996PubMed
6,445,868Regulatory T-cell subpopulations in pregnancy. II. Evidence for suppressive activity of the late phase of MLR.Immunology1980https://conductscience.org/library/papers/6445868PubMed
6,445,400Antigen-specific T cell-mediated suppression. V. H-2-linked genetic control of distinct antigen-specific defects in the production and activity of L-glutamic acid50-L-tyrosine50 suppressor factor.J Exp Med1980https://conductscience.org/library/papers/6445400PubMed
6,445,398Antigen- and receptor-driven regulatory mechanisms. IV. Idiotype-bearing I-J+ suppressor T cell factors induce second-order suppressor T cells which express anti-idiotypic receptors.J Exp Med1980https://conductscience.org/library/papers/6445398PubMed
6,444,663Feedback suppression of the immune response in vitro. I. Activity of antigen-stimulated B cells.J Exp Med1980https://conductscience.org/library/papers/6444663PubMed

1 to 10 of 30

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Genes0

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None in this release.

Drugs0

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None in this release.

Data0

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None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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