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Paper75236

Induction of specific immune unresponsiveness with purified mixed leukocyte culture-activated T lymphoblasts as autoimmunogen. III. Proof for the existence of autoanti-idiotypic killer T cells and transfer of suppression to normal syngeneic recipients by T or B lymphocytes.

Binz H and 1 other. J Exp Med, 1978. Cited by 66 papers, by iCite.

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ConductScience Library. Induction of specific immune unresponsiveness with purified mixed leukocyte culture-activated T lymphoblasts as autoimmunogen. III. Proof for the existence of autoanti-idiotypic killer T cells and transfer of suppression to normal syngeneic recipients by T or B lymphocytes. Papers, record 75236. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/75236

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Induction of specific immune unresponsiveness with purified mixed leukocyte culture-activated T lymphoblasts as autoimmunogen. III. Proof for the existence of autoanti-idiotypic killer T cells and transfer of suppression to normal syngeneic recipients by T or B lymphocytes.
PubMed
Journal
J Exp Med
PubMed
Year
1978
PubMed
Publication types
Journal Article, Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
66
iCite
Relative citation ratio, by iCite
1.67
iCite
Revised in PubMed
2021-12-03
PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Binz HH
2Wigzell HH

Source PubMed

Topics14

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
AutoantibodiesMajor topic
Immunosuppression TherapyMajor topic
T-LymphocytesMajor topic
Animals
Antibodies, Anti-Idiotypic
Antibody Specificity
Epitopes
Histocompatibility Antigens
Immune Tolerance
Immunoglobulins
Killer Cells, Natural
Lymphocyte Culture Test, Mixed
Mice
Mice, Inbred Strains

Source PubMed

References18

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
11,087,700Specific unresponsiveness to transplantation antigens induced by auto-immunisation with syngeneic, antigen-specific T lymphoblasts.Nature1976https://conductscience.org/library/papers/1087700PubMed
21,092,799Functional subclasses of T lymphocytes bearing different Ly antigens. II. Cooperation between subclasses of Ly+ cells in the generation of killer activity.J Exp Med1975https://conductscience.org/library/papers/1092799PubMed
311,993,330Induction of T and B cell immunity by anti-idiotypic antibody.Eur J Immunol1975https://conductscience.org/library/papers/11993330PubMed
412,245Specific transplantation tolerance induced by autoimmunization against the individual's own, naturally occurring idiotypic, antigen-binding receptors.J Exp Med1976https://conductscience.org/library/papers/12245PubMed
513,877,620The radiosensitive nature of homograft-rejecting and agglutinin-forming capacities of isolated spleen cells.J Immunol1962https://conductscience.org/library/papers/13877620PubMed
6302,312
Induction of specific immune unresponsiveness using purified mixed leukocyte culture-activated T lymphoblasts as autoimmunogen. I. Demonstration of general validity as to species and histocompatibility barriers.
J Exp Med1977https://conductscience.org/library/papers/302312PubMed
74,133,807Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system.Nature1974https://conductscience.org/library/papers/4133807PubMed
84,551,691Immune responses in vitro. I. Culture conditions for antibody synthesis.Cell Immunol1972https://conductscience.org/library/papers/4551691PubMed
94,943,147Infectious immunological tolerance.Immunology1971https://conductscience.org/library/papers/4943147PubMed
1050,400
Shared idiotypic determinants on B and T lymphocytes reactive against the same antigenic determinants. I. Demonstration of similar or identical idiotypes on IgG molecules and T-cell receptors with specificity for the same alloantigens.
J Exp Med1975https://conductscience.org/library/papers/50400PubMed
115,075,626Aliotypic antibodies.Transplant Rev1972https://conductscience.org/library/papers/5075626PubMed
1253,259
Shared idiotypic determinants on B and T lymphocytes reactive against the same antigenic determinants. II. Determination of frequency and characteristics of idiotypic T and B lymphocytes in normal rats using direct visualization.
J Exp Med1975https://conductscience.org/library/papers/53259PubMed
1353,260
Shared idiotypic determinants on B and T lymphocytes reactive against the same antigenic determinants. III. Physical fractionation of specific immunocompetent T lymphocytes by affinity chromatography using anti-idiotypic antibodies.
J Exp Med1975https://conductscience.org/library/papers/53260PubMed
1455,461Specific binding of alloantigens to T cells activated in the mixed lymphocyte reaction.J Exp Med1976https://conductscience.org/library/papers/55461PubMed
155,783,244Separation of cells by velocity sedimentation.J Cell Physiol1969https://conductscience.org/library/papers/5783244PubMed
165,944,347Quantitative studies of the adoptive immunological memory in mice. I. An age-dependent barrier to syngeneic transplantation.J Exp Med1966https://conductscience.org/library/papers/5944347PubMed
1768,888Antigen recognition by T cells activated in the mixed lymphocyte reaction: specific binding of allogeneic cell material after removal of surface-bound antigen by trypsin.Eur J Immunol1977https://conductscience.org/library/papers/68888PubMed
1875,235
Induction of specific immune unresponsiveness with purified mixed leukocyte culture-activated T lymphoblasts as autoimmunogen. II. An analysis of the effects measured at the cellular and serological levels.
J Exp Med1978https://conductscience.org/library/papers/75235PubMed

Cited by13

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 66 citations.

PMIDTitleJournalYearIn PapersSource
8,432,846Prolongation of survival of rat cardiac allografts by T cell vaccination.J Clin Invest1993https://conductscience.org/library/papers/8432846PubMed
7,000,209Proceedings of the Annual Meeting of the European Foundation for Bone Marrow Transplantation, Sils Maria (Engadine), Switzerland, April 13-16, 1980.Blut1980https://conductscience.org/library/papers/7000209PubMed
6,976,412Suppression of interstitial nephritis by auto-anti-idiotypic immunity.J Exp Med1982https://conductscience.org/library/papers/6976412PubMed
6,966,405Suppression of tumor rejection by autologous anti-idiotypic immunity.Proc Natl Acad Sci U S A1980https://conductscience.org/library/papers/6966405PubMed
6,600,685Studies on chemically induced tumors in rats: I. Heterogeneity of tumor cells and establishment of syngeneic, tumor-specific cytotoxic T cell clones.Experientia1983https://conductscience.org/library/papers/6600685PubMed
6,456,322Mechanisms of idiotype suppression. IV. Functional neutralization in mixtures of idiotype-specific suppressor and hapten-specific suppressor T cells.J Exp Med1981https://conductscience.org/library/papers/6456322PubMed
6,449,474Limiting dilution analysis of the suppressive effect mediated by alloantigen-primed cells.Immunology1980https://conductscience.org/library/papers/6449474PubMed
6,231,352
Antiidiotypic immunity in interstitial nephritis. II. Rats developing anti-tubular basement membrane disease fail to make an antiidiotypic regulatory response: the modulatory role of an RT7.1+, OX8- suppressor T cell mechanism.
J Exp Med1984https://conductscience.org/library/papers/6231352PubMed
6,229,792Cytotoxic T-cell precursors revealed in neonatally tolerant mice.Proc Natl Acad Sci U S A1984https://conductscience.org/library/papers/6229792PubMed
364,296Successful cardiac allografts in syngeneic radiation chimeras.Mol Cell Biochem1978https://conductscience.org/library/papers/364296PubMed
159,936Suppression of idiotype and generation of suppressor T cells with idiotype-conjugated thymocytes.J Exp Med1979https://conductscience.org/library/papers/159936PubMed
91,657Antigen- and receptor-driven regulatory mechanisms. II. Induction of suppressor T cells with idiotype-coupled syngeneic spleen cells.J Exp Med1979https://conductscience.org/library/papers/91657PubMed
85,255Recognition of antigens by T lymphocytes.Mol Cell Biochem1978https://conductscience.org/library/papers/85255PubMed

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

None in this release

  • Grants
  • Trials
  • Comments and corrections
  • Genes
  • Drugs
  • Data

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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