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Paper · 75237

H-2-restricted cytotoxic effectors generated in vitro by the addition of trinitrophenyl-conjugated soluble proteins.

Schmitt-Verhulst AM and 4 others. J Exp Med, 1978. Cited by 115 papers, by iCite.

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ConductScience Library. H-2-restricted cytotoxic effectors generated in vitro by the addition of trinitrophenyl-conjugated soluble proteins. Papers, record 75237. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/75237

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
H-2-restricted cytotoxic effectors generated in vitro by the addition of trinitrophenyl-conjugated soluble proteins.
PubMed
Journal
J Exp Med
PubMed
Year
1978
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
115
iCite
Relative citation ratio, by iCite
2.3
iCite
Revised in PubMed
2019-05-08
PubMed

Authors5

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Schmitt-Verhulst AMA M
2Pettinelli CBC B
3Henkart PAP A
4Lunney JKJ K
5Shearer GMG M

Source PubMed

Topics14

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Cytotoxicity, ImmunologicMajor topic
H-2 AntigensMajor topic
NitrobenzenesMajor topic
T-LymphocytesMajor topic
TrinitrobenzenesMajor topic
Animals
Carrier Proteins
Cells, Cultured
Dose-Response Relationship, Immunologic
Mice
Serum Albumin, Bovine
Solubility
Spleen
gamma-Globulins

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References28

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
11,079,848On the role of the H-2 histocompatibility complex in determining the specificity of cytotoxic effector cells sensitized against syngeneic trinitrophenyl-modified targets.J Exp Med1975https://conductscience.org/library/papers/1079848PubMed
21,079,924Interaction antigens detected by cytotoxic T cells with the major histocompatibility complex as modifier.Nature1975https://conductscience.org/library/papers/1079924PubMed
31,081,575In vitro cell-mediated immune responses to the male specific(H-Y) antigen in mice.J Exp Med1975https://conductscience.org/library/papers/1081575PubMed
41,086,219Cell-medicated cytotoxicity against ectromelia virus-infected target cells. III. Role of the H-2 gene complex.Eur J Immunol1975https://conductscience.org/library/papers/1086219PubMed
51,086,229Target cell-dependent T cell-mediated lysis of vaccinia virus-infected cells.Eur J Immunol1975https://conductscience.org/library/papers/1086229PubMed
61,087,329
Multiple H-2 linked immune response gene control of H-2 D-associated T-cell-mediated lympholysis to trinitrophenyl-modified autologous cells: Ir-like genes mapping to the left of I-A and within the I region.
J Exp Med1976https://conductscience.org/library/papers/1087329PubMed
71,244,419
Cell-mediated lympholysis of trinitrophenyl-modified autologous lymphocytes. Confirmation of genetic control of response to trinitrophenyl-modified H-2 antigens by the use of anti-H-2 and anti-Ia antibodies.
J Exp Med1976https://conductscience.org/library/papers/1244419PubMed
8177,884H-2 region product as determinant in immune cytolysis of syngeneic tumour cells by anti-MSV T lymphocytes.Nature1976https://conductscience.org/library/papers/177884PubMed
9233,918Joint recognition by cytotoxic T cells of inactivated Sendai virus and products of the major histocompatibility complex.J Exp Med1977https://conductscience.org/library/papers/233918PubMed
10325,135Antigen handling by guinea pig macrophages: further evidence for the sequestration of antigen relevant for activation of primed T lymphocytes.J Immunol1977https://conductscience.org/library/papers/325135PubMed

Cited by24

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 115 citations.

PMIDTitleJournalYearIn PapersSource
37,626,879Enhanced Membrane Fluidization and Cholesterol Displacement by 1-Heptanol Inhibit Mast Cell Effector Functions.Cells2023https://conductscience.org/library/papers/37626879PubMed
31,993,060Cytoskeletal Protein 4.1R Is a Positive Regulator of the FcεRI Signaling and Chemotaxis in Mast Cells.Front Immunol2019https://conductscience.org/library/papers/31993060PubMed
30,116,247Positive and Negative Regulatory Roles of C-Terminal Src Kinase (CSK) in FcεRI-Mediated Mast Cell Activation, Independent of the Transmembrane Adaptor PAG/CSK-Binding Protein.Front Immunol2018https://conductscience.org/library/papers/30116247PubMed
26,929,198New Regulatory Roles of Galectin-3 in High-Affinity IgE Receptor Signaling.Mol Cell Biol2016https://conductscience.org/library/papers/26929198PubMed
21,302,107Murine cytotoxic T-cell response to alphavirus is associated mainly withH- 2D ( k ).Immunogenetics1978https://conductscience.org/library/papers/21302107PubMed
17,587,407Rab27b regulates mast cell granule dynamics and secretion.Traffic2007https://conductscience.org/library/papers/17587407PubMed
10,049,941Cytotoxicity is mandatory for CD8(+) T cell-mediated contact hypersensitivity.J Exp Med1999https://conductscience.org/library/papers/10049941PubMed
8,406,579Anti-leucocyte function-associated antigen-1 antibodies inhibit T-cell activation following low-avidity and adhesion-independent interactions.Immunology1993https://conductscience.org/library/papers/8406579PubMed
7,492,304Biochemical and pharmacological studies with KT7692 and LY294002 on the role of phosphatidylinositol 3-kinase in Fc epsilon RI-mediated signal transduction.Biochem J1995https://conductscience.org/library/papers/7492304PubMed
7,320,686Protection against graft vs. host-associated immunosuppression in F1 mice. I. Activation of F1 regulatory cells by host-specific anti-major histocompatibility complex antibodies.J Exp Med1981https://conductscience.org/library/papers/7320686PubMed

1 to 10 of 24

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Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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