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Paper · 10049941

Cytotoxicity is mandatory for CD8(+) T cell-mediated contact hypersensitivity.

Kehren J and 9 others. J Exp Med, 1999. Cited by 184 papers, by iCite.

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ConductScience Library. Cytotoxicity is mandatory for CD8(+) T cell-mediated contact hypersensitivity. Papers, record 10049941. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/10049941

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Cytotoxicity is mandatory for CD8(+) T cell-mediated contact hypersensitivity.
PubMed
Journal
J Exp Med
PubMed
Year
1999
PubMed
Publication types
Journal Article, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
184
iCite
Relative citation ratio, by iCite
3.7
iCite
Revised in PubMed
2019-05-08
PubMed

Authors10

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Kehren JJ
2Desvignes CC
3Krasteva MM
4Ducluzeau MTM T
5Assossou OO
6Horand FF
7Hahne MM
8Kägi DD
9Kaiserlian DD
10Nicolas JFJ F

Source PubMed

Topics20

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
CD8-Positive T-LymphocytesMajor topic
Cytotoxicity, ImmunologicMajor topic
Dermatitis, ContactMajor topic
Animals
Cell Movement
Dinitrofluorobenzene
Fas Ligand Protein
Haptens
Histocompatibility Antigens Class I
Histocompatibility Antigens Class II
Interferon-gamma
Lymphoid Tissue
Membrane Glycoproteins
Mice
Mice, Inbred C57BL
Mice, Knockout
Perforin
Pore Forming Cytotoxic Proteins
Skin
fas Receptor

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References38

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
175,237H-2-restricted cytotoxic effectors generated in vitro by the addition of trinitrophenyl-conjugated soluble proteins.J Exp Med1978https://conductscience.org/library/papers/75237PubMed
214,099,450CELLULAR AND VASCULAR COMPONENTS OF ALLERGIC CONTACT DERMATITIS.Am J Pathol1963https://conductscience.org/library/papers/14099450PubMed
31,971,294Roles of CD4+ and CD8+ T cells in murine contact sensitivity revealed by in vivo monoclonal antibody depletion.J Immunol1990https://conductscience.org/library/papers/1971294PubMed
42,112,266Normal development of mice deficient in beta 2M, MHC class I proteins, and CD8+ T cells.Science1990https://conductscience.org/library/papers/2112266PubMed
51,909,605Mice lacking MHC class II molecules.Cell1991https://conductscience.org/library/papers/1909605PubMed
61,910,679The dendritic cell system and its role in immunogenicity.Annu Rev Immunol1991https://conductscience.org/library/papers/1910679PubMed
71,741,395Early molecular events in the induction phase of contact sensitivity.Proc Natl Acad Sci U S A1992https://conductscience.org/library/papers/1741395PubMed
87,678,113Fas involvement in Ca(2+)-independent T cell-mediated cytotoxicity.J Exp Med1993https://conductscience.org/library/papers/7678113PubMed
98,443,959Early time course of recruitment of immune surveillance in human skin after chemical provocation.Clin Exp Immunol1993https://conductscience.org/library/papers/8443959PubMed
107,684,425
Nickel chloride and cobalt chloride, two common contact sensitizers, directly induce expression of intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and endothelial leukocyte adhesion molecule (ELAM-1) by endothelial cells.
J Invest Dermatol1993https://conductscience.org/library/papers/7684425PubMed

1 to 10 of 38

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Cited by46

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 184 citations.

PMIDTitleJournalYearIn PapersSource
42,652,757Occupational Contact Dermatitis in the Post-COVID Era: From Barrier Dysfunction and Microbiome Dysbiosis to Prevention and Precision Management.J Clin Med2026https://conductscience.org/library/papers/42652757PubMed
40,474,707Cell-mediated mucositis of the oral cavity: narrative review on etiology, clinico-pathological aspects and malignant transformation.Pathologica2025https://conductscience.org/library/papers/40474707PubMed
38,726,130Helper T cell subsets: Development, function and clinical role in hypersensitivity reactions in the modern perspective.Heliyon2024https://conductscience.org/library/papers/38726130PubMed
38,255,849Anti-Inflammatory Effect of Fermented Cabbage Extract Containing Nitric Oxide Metabolites with Silica.Int J Mol Sci2024https://conductscience.org/library/papers/38255849PubMed
37,759,970Berry Extracts and Their Bioactive Compounds Mitigate LPS and DNFB-Mediated Dendritic Cell Activation and Induction of Antigen Specific T-Cell Effector Responses.Antioxidants (Basel)2023https://conductscience.org/library/papers/37759970PubMed
36,835,932Osteopontin and Regulatory T Cells in Effector Phase of Allergic Contact Dermatitis.J Clin Med2023https://conductscience.org/library/papers/36835932PubMed
36,476,273Combined application of dinitrofluorobenzene and ovalbumin induced AD-like dermatitis with an increase in helper T-cell cytokines and a prolonged Th2 response.BMC Immunol2022https://conductscience.org/library/papers/36476273PubMed
35,783,608An Atopic Dermatitis-Like Mouse Model by Alternate Epicutaneous Application of Dinitrofluorobenzene and an Extract of Dermatophagoides Farinae.Front Med (Lausanne)2022https://conductscience.org/library/papers/35783608PubMed
35,023,170Real-time imaging of inflammation and its resolution: It's apparent because it's transparent.Immunol Rev2022https://conductscience.org/library/papers/35023170PubMed
34,045,488Contact dermatitis.Nat Rev Dis Primers2021https://conductscience.org/library/papers/34045488PubMed

1 to 10 of 46

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Genes2

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
CD4920PubTator's text mininghttps://conductscience.org/library/genes/920NCBI Gene
CD8A925PubTator's text mininghttps://conductscience.org/library/genes/925NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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