Paper · 7531365

Biotherapy of B-cell precursor leukemia by targeting genistein to CD19-associated tyrosine kinases.

Uckun FM and 8 others. Science, 1995. Cited by 239 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

Cite this record

ConductScience Library. Biotherapy of B-cell precursor leukemia by targeting genistein to CD19-associated tyrosine kinases. Papers, record 7531365. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/7531365

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Biotherapy of B-cell precursor leukemia by targeting genistein to CD19-associated tyrosine kinases.; PubMed
Journal: Science; PubMed
Year: 1995; PubMed
Publication types: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/7531365/; PubMed
DOI: https://doi.org/10.1126/science.7531365; PubMed
The journal: https://conductscience.org/library/journal-index/0404511; PubMed
Citations, by iCite: 239; iCite
Relative citation ratio, by iCite: 6.08; iCite
Revised in PubMed: 2019-06-18; PubMed

Authors9

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Uckun FM	F M
2	Evans WE	W E
3	Forsyth CJ	C J
4	Waddick KG	K G
5	Ahlgren LT	L T
6	Chelstrom LM	L M
7	Burkhardt A	A
8	Bolen J	J
9	Myers DE	D E

Source PubMed

Topics19

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Antigens, CD	Major topic
Antigens, Differentiation, B-Lymphocyte	Major topic
Immunoconjugates	Major topic
Isoflavones	Major topic
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	Major topic
Protein-Tyrosine Kinases	Major topic
Animals
Antibodies, Monoclonal
Antigens, CD19
Apoptosis
DNA Damage
DNA, Neoplasm
Genistein
Leukemic Infiltration
Lymphocyte Specific Protein Tyrosine Kinase p56(lck)
Mice
Mice, SCID
Tissue Distribution
Tumor Cells, Cultured

Source PubMed

Grants4

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes it	Agency	Country	NIH project	Stated by	Source
CA-42111	NCI NIH HHS	United States	R01CA042111	PubMed and NIH	NIH RePORTER
CA-42633	NCI NIH HHS	United States	R01CA042633	PubMed and NIH	NIH RePORTER
CA-51425	NCI NIH HHS	United States	R01CA051425	PubMed and NIH	NIH RePORTER
			R29CA042111	NIH	NIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References0

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

None in this release.

Cited by34

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 239 citations.

PMID	Title	Journal	Year	In Papers	Source
37,838,981	Molecular pharmacology of the onco-TRP channel TRPV6.	Channels (Austin)	2023	https://conductscience.org/library/papers/37838981	PubMed
37,457,582	The influence of COVID-19 on colorectal cancer was investigated using bioinformatics and systems biology techniques.	Front Med (Lausanne)	2023	https://conductscience.org/library/papers/37457582	PubMed
37,160,865	Structural mechanism of human oncochannel TRPV6 inhibition by the natural phytoestrogen genistein.	Nat Commun	2023	https://conductscience.org/library/papers/37160865	PubMed
36,936,272	The role of isoflavones in augmenting the effects of radiotherapy.	Front Oncol	2022	https://conductscience.org/library/papers/36936272	PubMed
36,091,808	Discovery of genistein derivatives as potential SARS-CoV-2 main protease inhibitors by virtual screening, molecular dynamics simulations and ADMET analysis.	Front Pharmacol	2022	https://conductscience.org/library/papers/36091808	PubMed
35,815,271	Genistein: Therapeutic and Preventive Effects, Mechanisms, and Clinical Application in Digestive Tract Tumor.	Evid Based Complement Alternat Med	2022	https://conductscience.org/library/papers/35815271	PubMed
32,332,902	Phytochemical analysis and biological activities of in vitro cultured Nidularium procerum, a bromeliad vulnerable to extinction.	Sci Rep	2020	https://conductscience.org/library/papers/32332902	PubMed
30,292,138	Oligonucleotide Aptamer-Mediated Precision Therapy of Hematological Malignancies.	Mol Ther Nucleic Acids	2018	https://conductscience.org/library/papers/30292138	PubMed
25,892,662	Sustained proliferation in cancer: Mechanisms and novel therapeutic targets.	Semin Cancer Biol	2015	https://conductscience.org/library/papers/25892662	PubMed
24,910,947	CD19-antigen specific nanoscale liposomal formulation of a SYK P-site inhibitor causes apoptotic destruction of human B-precursor leukemia cells.	Integr Biol (Camb)	2014	https://conductscience.org/library/papers/24910947	PubMed

1 to 10 of 34

See all 34 cited by

Genes2

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes	Source
CD19	930	PubTator's text mining	https://conductscience.org/library/genes/930	NCBI Gene
TXK	7,294	PubTator's text mining	https://conductscience.org/library/genes/7294	NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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