Paper · 75941

Immunologic responsiveness of the C3H/HeJ mouse: differential ability of butanol-extracted lipopolysaccharide (LPS) to evoke LPS-mediated effects.

Goodman MG and 2 others. J Exp Med, 1978. Cited by 25 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Immunologic responsiveness of the C3H/HeJ mouse: differential ability of butanol-extracted lipopolysaccharide (LPS) to evoke LPS-mediated effects. Papers, record 75941. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/75941

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Immunologic responsiveness of the C3H/HeJ mouse: differential ability of butanol-extracted lipopolysaccharide (LPS) to evoke LPS-mediated effects.; PubMed
Journal: J Exp Med; PubMed
Year: 1978; PubMed
Publication types: Journal Article, Research Support, U.S. Gov't, P.H.S.; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/75941/; PubMed
DOI: https://doi.org/10.1084/jem.147.3.800; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC2184202/; PubMed
The journal: https://conductscience.org/library/journal-index/2985109R; PubMed
Citations, by iCite: 25; iCite
Relative citation ratio, by iCite: 0.7; iCite
Revised in PubMed: 2019-05-08; PubMed

Authors3

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Goodman MG	M G
2	Parks DE	D E
3	Weigle WO	W O

Source PubMed

Topics13

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Antibody Formation	Major topic
Lipopolysaccharides	Major topic
Lymphocyte Activation	Major topic
Lymphocytes	Major topic
Mice, Inbred C3H	Major topic
Polysaccharides, Bacterial	Major topic
Adjuvants, Immunologic
Animals
Butanols
Immune Tolerance
Male
Mice
gamma-Globulins

Source PubMed

Grants0

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Trials0

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None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References52

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	46,249	Immunologic properties of bacterial lipopolysaccharide (LPS): correlation between the mitogenic, adjuvant, and immunogenic activities.	J Immunol	1975	https://conductscience.org/library/papers/46249	PubMed
2	52,184	The effect of lipopolysaccharide on the primary immune response to the hapten NNP.	Scand J Immunol	1975	https://conductscience.org/library/papers/52184	PubMed
3	58,041	Specific suppression of the immune response by HGG tolerant spleen cells. I. Parameters affecting the level of suppression.	J Immunol	1976	https://conductscience.org/library/papers/58041	PubMed
4	67,150	Modulation of lipopolysaccharide (LPS)-mediated function by structural differences of two physically distinct fractions of Escherichia coli K235 LPS.	J Immunol	1977	https://conductscience.org/library/papers/67150	PubMed
5	72,110	Effect of lipopolysaccharide on immunogenicity and tolerogenicity of HGG in C57BL/6J nude mice: evidence for a possible B cell deficiency.	J Immunol	1977	https://conductscience.org/library/papers/72110	PubMed
6	165,259	Dissociation between mitogenicity and immunogenicity of TNP-lipopolysaccharide, a T-independent antigen.	J Exp Med	1975	https://conductscience.org/library/papers/165259	PubMed
7	182,900	Isolation of a lipid A bound polypeptide responsible for "LPS-initiated" mitogenesis of C3H/HeJ spleen cells.	J Exp Med	1976	https://conductscience.org/library/papers/182900	PubMed
8	187,699	Inhibition of the mitogenic response to lipopolysaccharide (LPS) in mouse spleen cells by polymyxin B.	J Immunol	1977	https://conductscience.org/library/papers/187699	PubMed
9	233,897	Nonspecific activation of murine lymphocytes. I. Proliferation and polyclonal activation induced by 2-mercaptoethanol and alpha-thioglycerol.	J Exp Med	1977	https://conductscience.org/library/papers/233897	PubMed
10	299,760	Immunologic properties of bacterial lipopolysaccharide (LPS). IV. Cellular basis of the unresponsiveness of C3H/HeJ mouse spleen cells to LPS-induced mitogenesis.	J Immunol	1977	https://conductscience.org/library/papers/299760	PubMed

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Cited by11

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 25 citations.

PMID	Title	Journal	Year	In Papers	Source
7,380,563	Generation and characterization of a lipopolysaccharide-induced and serum-derived cytotoxic factor for tumor cells.	Infect Immun	1980	https://conductscience.org/library/papers/7380563	PubMed
7,095,853	Immunological activities of Capnocytophaga cellular components.	Infect Immun	1982	https://conductscience.org/library/papers/7095853	PubMed
7,033,142	Failure of bacterial lipopolysaccharide to elicit a cytostatic effect on Plasmodium vinckei petteri in C3H/HeJ mice.	Infect Immun	1982	https://conductscience.org/library/papers/7033142	PubMed
7,000,681	Effect of lipid A-associated protein and lipid A on the expression of lipopolysaccharide activity. I. Immunological activity.	Immunology	1980	https://conductscience.org/library/papers/7000681	PubMed
6,783,538	Biological activities of Brucella abortus lipopolysaccharides.	Infect Immun	1981	https://conductscience.org/library/papers/6783538	PubMed
6,454,742	T cell regulation of polyclonal B cell responsiveness. III. Overt T helper and latent T suppressor activities from distinct subpopulations of unstimulated splenic T cells.	J Exp Med	1981	https://conductscience.org/library/papers/6454742	PubMed
702,060	Suppression of the immune response in C3H/HeJ mice by protein-free lipopolysaccharides.	J Exp Med	1978	https://conductscience.org/library/papers/702060	PubMed
372,482	Cellular requirements for lipopolysaccharide adjuvanticity. A role for both T lymphocytes and macrophages for in vitro responses to particulate antigens.	J Exp Med	1979	https://conductscience.org/library/papers/372482	PubMed
314,931	B-lymphocyte activation with an extract of Nocardia brasiliensis.	Infect Immun	1979	https://conductscience.org/library/papers/314931	PubMed
93,080	B-cell subsets responsive to fluorescein-conjugated antigens. III. Differential effect of E. Coli lipopolysaccharide on T-dependent and T-independent responses in vivo.	Immunology	1979	https://conductscience.org/library/papers/93080	PubMed

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Data0

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PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

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iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

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ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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