Paper · 7679498

RNase H domain mutations affect the interaction between Moloney murine leukemia virus reverse transcriptase and its primer-template.

Telesnitsky A and 1 other. Proc Natl Acad Sci U S A, 1993. Cited by 97 papers, by iCite.

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ConductScience Library. RNase H domain mutations affect the interaction between Moloney murine leukemia virus reverse transcriptase and its primer-template. Papers, record 7679498. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/7679498

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: RNase H domain mutations affect the interaction between Moloney murine leukemia virus reverse transcriptase and its primer-template.; PubMed
Journal: Proc Natl Acad Sci U S A; PubMed
Year: 1993; PubMed
Publication types: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/7679498/; PubMed
DOI: https://doi.org/10.1073/pnas.90.4.1276; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC45855/; PubMed
The journal: https://conductscience.org/library/journal-index/7505876; PubMed
Citations, by iCite: 97; iCite
Relative citation ratio, by iCite: 2.06; iCite
Revised in PubMed: 2019-05-01; PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	Kind	ORCID iD
1	Telesnitsky A	A
2	Goff SP	S P

Source PubMed

Topics16

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
DNA-Directed DNA Polymerase	Major topic
Moloney murine leukemia virus	Major topic
RNA-Directed DNA Polymerase	Major topic
Ribonuclease H	Major topic
Base Sequence
Binding Sites
Cloning, Molecular
DNA, Viral
Genes, pol
Macromolecular Substances
Molecular Sequence Data
Mutagenesis
Oligodeoxyribonucleotides
Polymerase Chain Reaction
Recombinant Proteins
Templates, Genetic

Source PubMed

Grants1

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes it	Agency	Country	NIH project	Stated by
R37 CA30488	NCI NIH HHS	United States	R37CA030488	PubMed and NIH

Source NIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References33

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	1,691,564	Mutational analysis of the ribonuclease H activity of human immunodeficiency virus 1 reverse transcriptase.	Virology	1990	https://conductscience.org/library/papers/1691564	PubMed
2	1,694,894	Retroviral reverse transcriptase: synthesis, structure, and function.	J Acquir Immune Defic Syndr (1988)	1990	https://conductscience.org/library/papers/1694894	PubMed
3	1,696,639	Template switching by reverse transcriptase during DNA synthesis.	J Virol	1990	https://conductscience.org/library/papers/1696639	PubMed
4	66,065	The reverse transcriptase.	Biochim Biophys Acta	1977	https://conductscience.org/library/papers/66065	PubMed
5	509,527	A detailed model of reverse transcription and tests of crucial aspects.	Cell	1979	https://conductscience.org/library/papers/509527	PubMed
6	6,165,830	Isolation and properties of Moloney murine leukemia virus mutants: use of a rapid assay for release of virion reverse transcriptase.	J Virol	1981	https://conductscience.org/library/papers/6165830	PubMed
7	2,410,413	Purification and characterization of murine retroviral reverse transcriptase expressed in Escherichia coli.	J Biol Chem	1985	https://conductscience.org/library/papers/2410413	PubMed
8	2,429,313	Computer analysis of retroviral pol genes: assignment of enzymatic functions to specific sequences and homologies with nonviral enzymes.	Proc Natl Acad Sci U S A	1986	https://conductscience.org/library/papers/2429313	PubMed
9	2,448,747	Isolation of cloned Moloney murine leukemia virus reverse transcriptase lacking ribonuclease H activity.	Nucleic Acids Res	1988	https://conductscience.org/library/papers/2448747	PubMed
10	2,450,347	Domain structure of the Moloney murine leukemia virus reverse transcriptase: mutational analysis and separate expression of the DNA polymerase and RNase H activities.	Proc Natl Acad Sci U S A	1988	https://conductscience.org/library/papers/2450347	PubMed

1 to 10 of 33

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Cited by39

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 97 citations.

PMID	Title	Journal	Year	In Papers	Source
42,351,540	Substrate Recognition Governs Reverse Transcriptase Resistance to Diagnostic Inhibitors in RT-qPCR.	Diagnostics (Basel)	2026	https://conductscience.org/library/papers/42351540	PubMed
42,168,701	AI-guided redesign of laboratory-evolved reverse transcriptases enhances prime editing.	Nat Biotechnol	2026	https://conductscience.org/library/papers/42168701	PubMed
37,794,706	Prime editing: Mechanism insight and recent applications in plants.	Plant Biotechnol J	2024	https://conductscience.org/library/papers/37794706	PubMed
37,657,419	Phage-assisted evolution and protein engineering yield compact, efficient prime editors.	Cell	2023	https://conductscience.org/library/papers/37657419	PubMed
34,998,953	A flexible split prime editor using truncated reverse transcriptase improves dual-AAV delivery in mouse liver.	Mol Ther	2022	https://conductscience.org/library/papers/34998953	PubMed
34,900,141	M-MuLV reverse transcriptase: Selected properties and improved mutants.	Comput Struct Biotechnol J	2021	https://conductscience.org/library/papers/34900141	PubMed
33,534,838	Open-source RNA extraction and RT-qPCR methods for SARS-CoV-2 detection.	PLoS One	2021	https://conductscience.org/library/papers/33534838	PubMed
24,741,085	Determinants of Moloney murine leukemia virus Gag-Pol and genomic RNA proportions.	J Virol	2014	https://conductscience.org/library/papers/24741085	PubMed
23,444,139	Altered error specificity of RNase H-deficient HIV-1 reverse transcriptases during DNA-dependent DNA synthesis.	Nucleic Acids Res	2013	https://conductscience.org/library/papers/23444139	PubMed
23,382,176	Structural analysis of monomeric retroviral reverse transcriptase in complex with an RNA/DNA hybrid.	Nucleic Acids Res	2013	https://conductscience.org/library/papers/23382176	PubMed

1 to 10 of 39

See all 39 cited by

Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

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ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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