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Paper · 78964

In a fully H-2 incompatible chimera, T cells of donor origin can respond to minor histocompatibility antigens in association with either donor or host H-2 type.

Matzinger P and 1 other. J Exp Med, 1978. Cited by 108 papers, by iCite.

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ConductScience Library. In a fully H-2 incompatible chimera, T cells of donor origin can respond to minor histocompatibility antigens in association with either donor or host H-2 type. Papers, record 78964. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/78964

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
In a fully H-2 incompatible chimera, T cells of donor origin can respond to minor histocompatibility antigens in association with either donor or host H-2 type.
PubMed
Journal
J Exp Med
PubMed
Year
1978
PubMed
Publication types
Journal Article, Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
108
iCite
Relative citation ratio, by iCite
1.96
iCite
Revised in PubMed
2019-05-08
PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Matzinger PP
2Mirkwood GG

Source PubMed

Topics13

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
H-2 AntigensMajor topic
Radiation ChimeraMajor topic
T-LymphocytesMajor topic
Animals
Bone Marrow Transplantation
Cytotoxicity, Immunologic
Epitopes
Histocompatibility
Killer Cells, Natural
Lymphocyte Cooperation
Mice
Spleen
Transplantation, Homologous

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References15

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
11,000,487Standardized nomenclature for inbred strains of mice: sixth listing.Cancer Res1976https://conductscience.org/library/papers/1000487PubMed
21,081,575In vitro cell-mediated immune responses to the male specific(H-Y) antigen in mice.J Exp Med1975https://conductscience.org/library/papers/1081575PubMed
31,082,923Virus and trinitrophenol hapten-specific T-cell-mediated cytotoxicity against H-2 incompatible target cells.J Exp Med1976https://conductscience.org/library/papers/1082923PubMed
4141,046Killer cells reactive to altered-self antigens can also be alloreactive.Proc Natl Acad Sci U S A1977https://conductscience.org/library/papers/141046PubMed
520,229Induction of H-2-restricted cytotoxic T cells: in vivo induction has the appearance of being unrestricted.Cell Immunol1977https://conductscience.org/library/papers/20229PubMed
6302,181The role of the histocompatibilty gene complex in lymphocyte defferetiation.Cold Spring Harb Symp Quant Biol1977https://conductscience.org/library/papers/302181PubMed
7302,918In a radiation chimaera, host H-2 antigens determine immune responsiveness of donor cytotoxic cells.Nature1977https://conductscience.org/library/papers/302918PubMed
8305,459On the thymus in the differentiation of "H-2 self-recognition" by T cells: evidence for dual recognition?J Exp Med1978https://conductscience.org/library/papers/305459PubMed
94,122,709
Cell interactions between histoincompatible T and B lymphocytes. II. Failure of physiologic cooperative interactions between T and B lymphocytes from allogeneic donor strains in humoral response to hapten-protein conjugates.
J Exp Med1973https://conductscience.org/library/papers/4122709PubMed
104,139,718Cellular immunity against Rous sarcomas of chickens. Preferential reactivity against autochthonous target cells as determined by lymphocyte adherence and cytotoxicity tests in vitro.Proc Natl Acad Sci U S A1974https://conductscience.org/library/papers/4139718PubMed

1 to 10 of 15

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Cited by29

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 108 citations.

PMIDTitleJournalYearIn PapersSource
28,007,764Crediting animals in scientific literature: Recognition in addition to Replacement, Reduction, & Refinement [4R].EMBO Rep2017https://conductscience.org/library/papers/28007764PubMed
27,346,961What's in a name? The problem of authors' names in research articles.Biochem Med (Zagreb)2016https://conductscience.org/library/papers/27346961PubMed
25,348,894Writers Blocked: On the Wrongs of Research Co-authorship and Some Possible Strategies for Improvement.Sci Eng Ethics2015https://conductscience.org/library/papers/25348894PubMed
24,517,426Transplantation tolerance: from theory to clinic.Immunol Rev2014https://conductscience.org/library/papers/24517426PubMed
21,357,265Rapid reconstitution of antibody responses following transplantation of purified allogeneic hematopoietic stem cells.J Immunol2011https://conductscience.org/library/papers/21357265PubMed
16,983,067Functional CD8+ but not CD4+ T cell responses develop independent of thymic epithelial MHC.Proc Natl Acad Sci U S A2006https://conductscience.org/library/papers/16983067PubMed
12,574,503Efficient T cell repertoire selection in tetraparental chimeric mice independent of thymic epithelial MHC.Proc Natl Acad Sci U S A2003https://conductscience.org/library/papers/12574503PubMed
10,393,953On the role of thymic epithelium vs. bone marrow-derived cells in repertoire selection of T cells.Proc Natl Acad Sci U S A1999https://conductscience.org/library/papers/10393953PubMed
8,464,889Class II-positive hematopoietic cells cannot mediate positive selection of CD4+ T lymphocytes in class II-deficient mice.Proc Natl Acad Sci U S A1993https://conductscience.org/library/papers/8464889PubMed
7,276,826
Antigen recognition. V. Requirement for histocompatibility between antigen-presenting cell and B cell in the response to a thymus-dependent antigen, and lack of allogeneic restriction between T and B cells.
J Exp Med1981https://conductscience.org/library/papers/7276826PubMed

1 to 10 of 29

See all 29 cited by

Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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