Paper · 791735

The insulin receptor: its role in insulin resistance of obesity and diabetes.

Olefsky JM. Diabetes, 1976. Cited by 366 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. The insulin receptor: its role in insulin resistance of obesity and diabetes. Papers, record 791735. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/791735

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: The insulin receptor: its role in insulin resistance of obesity and diabetes.; PubMed
Journal: Diabetes; PubMed
Year: 1976; PubMed
Publication types: Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S., Review; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/791735/; PubMed
DOI: https://doi.org/10.2337/diab.25.12.1154; PubMed
The journal: https://conductscience.org/library/journal-index/0372763; PubMed
Citations, by iCite: 366; iCite
Relative citation ratio, by iCite: 11.6; iCite
Revised in PubMed: 2019-05-15; PubMed

Authors1

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	Kind	ORCID iD
1	Olefsky JM	J M

Source PubMed

Topics13

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Diabetes Mellitus	Major topic
Insulin Resistance	Major topic
Obesity	Major topic
Receptor, Insulin	Major topic
Adipose Tissue
Adult
Animals
Child
Deoxyglucose
Dose-Response Relationship, Drug
Humans
Insulin
Protein Binding

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References0

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

None in this release.

Cited by64

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 366 citations.

PMID	Title	Journal	Year	In Papers	Source
39,948,335	Pancreatic endocrine and exocrine signaling and crosstalk in physiological and pathological status.	Signal Transduct Target Ther	2025	https://conductscience.org/library/papers/39948335	PubMed
39,006,920	Discovering novel Cathepsin L inhibitors from natural products using artificial intelligence.	Comput Struct Biotechnol J	2024	https://conductscience.org/library/papers/39006920	PubMed
38,024,370	The relationship between central obesity and risk of breast cancer: a dose-response meta-analysis of 7,989,315 women.	Front Nutr	2023	https://conductscience.org/library/papers/38024370	PubMed
37,211,853	To Explore the Putative Molecular Targets of Diabetic Nephropathy and their Inhibition Utilizing Potential Phytocompounds.	Curr Med Chem	2024	https://conductscience.org/library/papers/37211853	PubMed
37,055,497	Structural basis of the alkaline pH-dependent activation of insulin receptor-related receptor.	Nat Struct Mol Biol	2023	https://conductscience.org/library/papers/37055497	PubMed
36,413,010	Molecular basis for the role of disulfide-linked αCTs in the activation of insulin-like growth factor 1 receptor and insulin receptor.	Elife	2022	https://conductscience.org/library/papers/36413010	PubMed
35,715,229	Cryo-electron Microscopic Analysis of Single-Pass Transmembrane Receptors.	Chem Rev	2022	https://conductscience.org/library/papers/35715229	PubMed
35,361,965	Synergistic activation of the insulin receptor via two distinct sites.	Nat Struct Mol Biol	2022	https://conductscience.org/library/papers/35361965	PubMed
33,477,364	Modulation of Insulin Sensitivity by Insulin-Degrading Enzyme.	Biomedicines	2021	https://conductscience.org/library/papers/33477364	PubMed
31,436,533	Activation mechanism of the insulin receptor revealed by cryo-EM structure of the fully liganded receptor-ligand complex.	Elife	2019	https://conductscience.org/library/papers/31436533	PubMed

1 to 10 of 64

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Genes1

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes
INSR	3,643	PubTator's text mining	https://conductscience.org/library/genes/3643

Source NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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