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Paper8090727

An efficient and flexible system for construction of adenovirus vectors with insertions or deletions in early regions 1 and 3.

Bett AJ and 3 others. Proc Natl Acad Sci U S A, 1994. Cited by 652 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. An efficient and flexible system for construction of adenovirus vectors with insertions or deletions in early regions 1 and 3. Papers, record 8090727. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/8090727

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
An efficient and flexible system for construction of adenovirus vectors with insertions or deletions in early regions 1 and 3.
PubMed
Journal
Proc Natl Acad Sci U S A
PubMed
Year
1994
PubMed
Publication types
Journal Article, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
652
iCite
Relative citation ratio, by iCite
14.3
iCite
Revised in PubMed
2019-05-01
PubMed

Authors4

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Bett AJA J
2Haddara WW
3Prevec LL
4Graham FLF L

Source PubMed

Topics9

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
AdenoviridaeMajor topic
Gene Transfer TechniquesMajor topic
Genetic VectorsMajor topic
Base Sequence
Genes, Viral
Molecular Sequence Data
Plasmids
Sequence Deletion
Viral Structural Proteins

Source PubMed

Trials1

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

TrialTitleThe trial lists it asNamed in the paper's record
NCT02485912Evaluation of a New Ebola Vaccine Using a Short-interval Prime-boost VaccinationBackground

Source ClinicalTrials.gov

References33

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
14,705,382A new technique for the assay of infectivity of human adenovirus 5 DNA.Virology1973https://conductscience.org/library/papers/4705382PubMed
2957,486Genome structure of incomplete particles of adenovirus.J Virol1976https://conductscience.org/library/papers/957486PubMed
3886,304Characteristics of a human cell line transformed by DNA from human adenovirus type 5.J Gen Virol1977https://conductscience.org/library/papers/886304PubMed
4902,315Viral DNA sequences from incomplete particles of human adenovirus type 7.Cell1977https://conductscience.org/library/papers/902315PubMed
5476,833Isolation of adenovirus type 5 host range deletion mutants defective for transformation of rat embryo cells.Cell1979https://conductscience.org/library/papers/476833PubMed
6388,356A rapid alkaline extraction procedure for screening recombinant plasmid DNA.Nucleic Acids Res1979https://conductscience.org/library/papers/388356PubMed
77,418,007Encapsidation of adenovirus 16 DNA is directed by a small DNA sequence at the left end of the genome.Cell1980https://conductscience.org/library/papers/7418007PubMed
86,265,795In vivo consequences of plasmid topology.Nature1981https://conductscience.org/library/papers/6265795PubMed
96,754,531Tn5 mutagenesis of the transforming genes of human adenovirus type 5.Gene1982https://conductscience.org/library/papers/6754531PubMed
106,823,294Covalently closed circles of adenovirus 5 DNA.Nature1983https://conductscience.org/library/papers/6823294PubMed
116,871,991The adenovirus type 5 E1A transcriptional control region contains a duplicated enhancer element.Cell1983https://conductscience.org/library/papers/6871991PubMed
126,310,523Generation of adenovirus by transfection of plasmids.Nucleic Acids Res1983https://conductscience.org/library/papers/6310523PubMed
136,312,322Viability of lambda phages carrying a perfect palindrome in the absence of recombination nucleases.Nature1983https://conductscience.org/library/papers/6312322PubMed
146,330,982Polarity in adenovirus recombination.Virology1984https://conductscience.org/library/papers/6330982PubMed
152,981,456DNA sequence of the early E3 transcription unit of adenovirus 5.Virology1985https://conductscience.org/library/papers/2981456PubMed
166,098,454Covalently closed circles of human adenovirus DNA are infectious.EMBO J1984https://conductscience.org/library/papers/6098454PubMed
173,001,349Development of a helper-independent human adenovirus vector and its use in the transfer of the herpes simplex virus thymidine kinase gene.J Virol1986https://conductscience.org/library/papers/3001349PubMed
182,938,742The adenovirus type 5 E1A enhancer contains two functionally distinct domains: one is specific for E1A and the other modulates all early units in cis.Cell1986https://conductscience.org/library/papers/2938742PubMed
193,472,993Human adenovirus cloning vectors based on infectious bacterial plasmids.Gene1986https://conductscience.org/library/papers/3472993PubMed
203,599,182Identification of a repeated sequence element required for efficient encapsidation of the adenovirus type 5 chromosome.J Virol1987https://conductscience.org/library/papers/3599182PubMed

See all 33 references

Cited by241

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 652 citations.

PMIDTitleJournalYearIn PapersSource
42,516,141Recombinant adenoviruses application for cancer vaccines: from genetic design to clinical translation.Front Oncol2026https://conductscience.org/library/papers/42516141PubMed
41,898,407Genomic Context and Insert Orientation in the Regulation of Transgene Expression in Adenoviral Vectors.Int J Mol Sci2026https://conductscience.org/library/papers/41898407PubMed
40,595,664Single-dose intranasal adenovirus-based RSV vaccines targeting G and M2.NPJ Vaccines2025https://conductscience.org/library/papers/40595664PubMed
40,295,404Development of viral infectious clones and their applications based on yeast and bacterial artificial chromosome platforms.Mol Biomed2025https://conductscience.org/library/papers/40295404PubMed
40,127,471Harnessing live vectors for cancer vaccines: Advancing therapeutic immunotherapy.Hum Vaccin Immunother2025https://conductscience.org/library/papers/40127471PubMed
39,765,719Adenoviral Vectors for Gene Therapy of Hereditary Diseases.Biology (Basel)2024https://conductscience.org/library/papers/39765719PubMed
39,596,515Development and Characterization of an Oncolytic Human Adenovirus-Based Vector Co-Expressing the Adenovirus Death Protein and p14 Fusion-Associated Small Transmembrane Fusogenic Protein.Int J Mol Sci2024https://conductscience.org/library/papers/39596515PubMed
39,559,559FastAd: A versatile toolkit for rapid generation of single adenoviruses or diverse adenoviral vector libraries.Mol Ther Methods Clin Dev2024https://conductscience.org/library/papers/39559559PubMed
39,526,770Up-regulation of HIF-1α in refractory sudden sensorineural hearing loss.Acta Otorhinolaryngol Ital2024https://conductscience.org/library/papers/39526770PubMed
39,203,977A Simple and Versatile Method for Ex Vivo Monitoring of Goat Vaginal Mucosa Transduction by Viral Vector Vaccines.Vaccines (Basel)2024https://conductscience.org/library/papers/39203977PubMed
39,201,470Construction and Stability of All-in-One Adenovirus Vectors Simultaneously Expressing Four and Eight Multiplex Guide RNAs and Cas9 Nickase.Int J Mol Sci2024https://conductscience.org/library/papers/39201470PubMed
39,144,987Viral vector- and virus-like particle-based vaccines against infectious diseases: A minireview.Heliyon2024https://conductscience.org/library/papers/39144987PubMed
39,057,750Humoral Immune Response in Immunized Sheep with Bovine Coronavirus Glycoproteins Delivered via an Adenoviral Vector.Pathogens2024https://conductscience.org/library/papers/39057750PubMed
38,543,743Advances of Recombinant Adenoviral Vectors in Preclinical and Clinical Applications.Viruses2024https://conductscience.org/library/papers/38543743PubMed
38,003,709Adenoviral Gene Therapy Vectors in Clinical Use-Basic Aspects with a Special Reference to Replication-Competent Adenovirus Formation and Its Impact on Clinical Safety.Int J Mol Sci2023https://conductscience.org/library/papers/38003709PubMed
37,568,151CFTR dysfunction in smooth muscle drives TGFβ dependent airway hyperreactivity.Respir Res2023https://conductscience.org/library/papers/37568151PubMed
37,512,632Basic Principles of RNA Interference: Nucleic Acid Types and In Vitro Intracellular Delivery Methods.Micromachines (Basel)2023https://conductscience.org/library/papers/37512632PubMed
37,219,458Targeting Cell Cycle Facilitates E1A-Independent Adenoviral Replication.J Virol2023https://conductscience.org/library/papers/37219458PubMed
36,218,358Human Cytomegalovirus Utilizes Multiple Viral Proteins to Regulate the Basement Membrane Protein Nidogen 1.J Virol2022https://conductscience.org/library/papers/36218358PubMed
35,955,566Pseudomonas Aeruginosa Lung Infection Subverts Lymphocytic Responses through IL-23 and IL-22 Post-Transcriptional Regulation.Int J Mol Sci2022https://conductscience.org/library/papers/35955566PubMed

See all 241 cited by

Genes1

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn Genes
AD58,081PubTator's text mininghttps://conductscience.org/library/genes/8081

Source NCBI Gene

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

None in this release

  • Grants
  • Comments and corrections
  • Drugs
  • Data

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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