Paper8212

Glutamine-stimulated modification and degradation of glutamine synthetase in hepatoma tissue culture cells.

Arad G and 2 others. Cell, 1976. Cited by 51 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

Cite this record

ConductScience Library. Glutamine-stimulated modification and degradation of glutamine synthetase in hepatoma tissue culture cells. Papers, record 8212. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/8212

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Glutamine-stimulated modification and degradation of glutamine synthetase in hepatoma tissue culture cells.; PubMed
Journal: Cell; PubMed
Year: 1976; PubMed
Publication types: Journal Article; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/8212/; PubMed
DOI: https://doi.org/10.1016/0092-8674(76)90190-2; PubMed
The journal: https://conductscience.org/library/journal-index/0413066; PubMed
Citations, by iCite: 51; iCite
Relative citation ratio, by iCite: 1.04; iCite
Revised in PubMed: 2019-07-05; PubMed

Authors3

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Arad G	G
2	Freikopf A	A
3	Kulka RG	R G

Source PubMed

Topics8

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Glutamate-Ammonia Ligase	Major topic
Glutamine	Major topic
Animals
Cell Line
Immunodiffusion
Immunoelectrophoresis
Liver
Rats

Source PubMed

Show 2 more topicsShow fewer topics

Cited by18

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 51 citations.

PMID	Title	Journal	Year	In Papers	Source
42,862,727	Product-stabilized filamentation by human glutamine synthetase allosterically tunes metabolic activity.	Elife	2026	https://conductscience.org/library/papers/42862727	PubMed
41,461,925	PCMT1 generates the C-terminal cyclic imide degron on CRBN substrates.	Nat Chem Biol	2026	https://conductscience.org/library/papers/41461925	PubMed
36,741,028	Glutamine synthetase expression rescues human dendritic cell survival in a glutamine-deprived environment.	Front Oncol	2023	https://conductscience.org/library/papers/36741028	PubMed
34,583,995	USP15 antagonizes CRL4CRBN-mediated ubiquitylation of glutamine synthetase and neosubstrates.	Proc Natl Acad Sci U S A	2021	https://conductscience.org/library/papers/34583995	PubMed
34,235,580	Hepatoblastoma: glutamine depletion hinders cell viability in the embryonal subtype but high GLUL expression is associated with better overall survival.	J Cancer Res Clin Oncol	2021	https://conductscience.org/library/papers/34235580	PubMed
32,993,179	Macrophage Stimulated by Low Ambient Temperature Hasten Tumor Growth via Glutamine Production.	Biomedicines	2020	https://conductscience.org/library/papers/32993179	PubMed
29,551,266	Multiplexed Proteome Dynamics Profiling Reveals Mechanisms Controlling Protein Homeostasis.	Cell	2018	https://conductscience.org/library/papers/29551266	PubMed
28,320,958	p97/VCP promotes degradation of CRBN substrate glutamine synthetase and neosubstrates.	Proc Natl Acad Sci U S A	2017	https://conductscience.org/library/papers/28320958	PubMed
26,990,986	Glutamine Triggers Acetylation-Dependent Degradation of Glutamine Synthetase via the Thalidomide Receptor Cereblon.	Mol Cell	2016	https://conductscience.org/library/papers/26990986	PubMed
17,197,094	Glutamine, insulin and glucocorticoids regulate glutamine synthetase expression in C2C12 myotubes, Hep G2 hepatoma cells and 3T3 L1 adipocytes.	Biochim Biophys Acta	2007	https://conductscience.org/library/papers/17197094	PubMed
7,813,440	Regulated degradation of the transcription factor Gcn4.	EMBO J	1994	https://conductscience.org/library/papers/7813440	PubMed
6,128,685	Glutamine synthetase and glutamyltransferase activities in the mouse astrocyte in vitro.	Neurochem Res	1982	https://conductscience.org/library/papers/6128685	PubMed
2,907,404	Genetic determinants of glutamine synthetase in Drosophila melanogaster: a gene for glutamine synthetase I resides in the 21B3-6 region.	Biochem Genet	1988	https://conductscience.org/library/papers/2907404	PubMed
2,894,616	Effects of medium glutamine, glutamate, and ammonia on glutamine synthetase activity in cultured mouse astroglial cells.	Neurochem Res	1987	https://conductscience.org/library/papers/2894616	PubMed
2,868,445	The cloning and nucleotide sequence of cDNA for an amplified glutamine synthetase gene from the Chinese hamster.	Nucleic Acids Res	1986	https://conductscience.org/library/papers/2868445	PubMed
83,141	Effect of glutamine on the degradation of glutamine synthetase in hepatoma tissue-culture cells.	Biochem J	1978	https://conductscience.org/library/papers/83141	PubMed
31,352	Nitrogen source regulates glutamine synthetase mRNA levels in Neurospora crassa.	J Bacteriol	1978	https://conductscience.org/library/papers/31352	PubMed
26,055	Regulation of glutamine synthetase in cultured 3T3-L1 cells by insulin, hydrocortisone, and dibutyryl cyclic AMP.	Proc Natl Acad Sci U S A	1978	https://conductscience.org/library/papers/26055	PubMed

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Genes1

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes
GLUL	2,752	PubTator's text mining	https://conductscience.org/library/genes/2752

Source NCBI Gene

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

None in this release

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Trials
Comments and corrections
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Data

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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