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Paper83141

Effect of glutamine on the degradation of glutamine synthetase in hepatoma tissue-culture cells.

Crook RB and 1 other. Biochem J, 1978. Cited by 29 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Effect of glutamine on the degradation of glutamine synthetase in hepatoma tissue-culture cells. Papers, record 83141. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/83141

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Effect of glutamine on the degradation of glutamine synthetase in hepatoma tissue-culture cells.
PubMed
Journal
Biochem J
PubMed
Year
1978
PubMed
Publication types
Journal Article, Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
29
iCite
Relative citation ratio, by iCite
0.61
iCite
Revised in PubMed
2019-05-01
PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Crook RBR B
2Tomkins GMG M

Source PubMed

Topics8

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Glutamate-Ammonia LigaseMajor topic
GlutamineMajor topic
Liver Neoplasms, ExperimentalMajor topic
Animals
Cell Line
Cycloheximide
Dactinomycin
Kinetics

Source PubMed

References12

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
213,941,956Mechanism of D-glutamyltransferase repression in mammalian cells.Biochim Biophys Acta1963https://conductscience.org/library/papers/13941956PubMed
314,084,730SYNTHESIS OF EXPERIMENTALLY INDUCED GLUTAMINE SYNTHETASE (GLUTAMOTRANSFERASE ACTIVITY) IN EMBRYONIC CHICK RETINA IN VITRO.Dev Biol1963https://conductscience.org/library/papers/14084730PubMed
4234,454Immunochemical evidence for glutamine-mediated degradation of glutamine synthetase in cultured Chinese hamster cells.J Biol Chem1975https://conductscience.org/library/papers/234454PubMed
54,147,654Regulation of glutamine synthetase activity of hepatoma tissue culture cells by glutamine and dexamethasone.J Biol Chem1973https://conductscience.org/library/papers/4147654PubMed
64,383,907Effect of inhibitors of nucleic acid synthesis on steroid-mediated induction of tyrosine aminotransferase in hepatoma cell cultures.J Mol Biol1967https://conductscience.org/library/papers/4383907PubMed
78,212Glutamine-stimulated modification and degradation of glutamine synthetase in hepatoma tissue culture cells.Cell1976https://conductscience.org/library/papers/8212PubMed
84,402,645Clonal differences in glutamine synthetase activity of hepatoma cells. Effects of glutamine and dexamethasone.J Cell Biol1972https://conductscience.org/library/papers/4402645PubMed
94,403,489Regulation of glutamine synthetase in cultured Chinese hamster cells. Induction and repression by glutamine.J Biol Chem1972https://conductscience.org/library/papers/4403489PubMed
104,404,239Properties of a specific protease for pyridoxal enzymes and its biological role.J Biol Chem1972https://conductscience.org/library/papers/4404239PubMed
114,558,263[Mutant tRNA His ineffective in repression and lacking two pseudouridine modifications].Nat New Biol1972https://conductscience.org/library/papers/4558263PubMed
125,542,684Studies on the degradation of tyrosine aminotransferase in hepatoma cells in culture. Influence of the composition of the medium and adenosine triphosphate dependence.J Biol Chem1971https://conductscience.org/library/papers/5542684PubMed
134,385,387Evidence for the steroid-induced accumulation of tyrosine-aminotransferase messenger RNA in the absence of protein synthesis.Proc Natl Acad Sci U S A1968https://conductscience.org/library/papers/4385387PubMed

Cited by8

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 29 citations.

PMIDTitleJournalYearIn PapersSource
36,741,028Glutamine synthetase expression rescues human dendritic cell survival in a glutamine-deprived environment.Front Oncol2023https://conductscience.org/library/papers/36741028PubMed
34,583,995USP15 antagonizes CRL4CRBN-mediated ubiquitylation of glutamine synthetase and neosubstrates.Proc Natl Acad Sci U S A2021https://conductscience.org/library/papers/34583995PubMed
34,235,580Hepatoblastoma: glutamine depletion hinders cell viability in the embryonal subtype but high GLUL expression is associated with better overall survival.J Cancer Res Clin Oncol2021https://conductscience.org/library/papers/34235580PubMed
28,320,958p97/VCP promotes degradation of CRBN substrate glutamine synthetase and neosubstrates.Proc Natl Acad Sci U S A2017https://conductscience.org/library/papers/28320958PubMed
27,118,759De Novo Glutamine Synthesis: Importance for the Proliferation of Glioma Cells and Potentials for Its Detection With 13N-Ammonia.Mol Imaging2016https://conductscience.org/library/papers/27118759PubMed
26,990,986Glutamine Triggers Acetylation-Dependent Degradation of Glutamine Synthetase via the Thalidomide Receptor Cereblon.Mol Cell2016https://conductscience.org/library/papers/26990986PubMed
17,197,094Glutamine, insulin and glucocorticoids regulate glutamine synthetase expression in C2C12 myotubes, Hep G2 hepatoma cells and 3T3 L1 adipocytes.Biochim Biophys Acta2007https://conductscience.org/library/papers/17197094PubMed
16,662,744Rhythms in glutamine synthetase activity, energy charge, and glutamine in sunflower roots.Plant Physiol1982https://conductscience.org/library/papers/16662744PubMed

Genes1

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn Genes
GLUL2,752PubTator's text mininghttps://conductscience.org/library/genes/2752

Source NCBI Gene

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

None in this release

  • Grants
  • Trials
  • Comments and corrections
  • Drugs
  • Data

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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