Paper · 8380452

Analysis of the thymidine kinase genes from acyclovir-resistant mutants of varicella-zoster virus isolated from patients with AIDS.

Talarico CL and 2 others. J Virol, 1993. Cited by 84 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

Cite this record

ConductScience Library. Analysis of the thymidine kinase genes from acyclovir-resistant mutants of varicella-zoster virus isolated from patients with AIDS. Papers, record 8380452. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/8380452

On this page

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Analysis of the thymidine kinase genes from acyclovir-resistant mutants of varicella-zoster virus isolated from patients with AIDS.; PubMed
Journal: J Virol; PubMed
Year: 1993; PubMed
Publication types: Comparative Study, Journal Article; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/8380452/; PubMed
DOI: https://doi.org/10.1128/jvi.67.2.1024-1033.1993; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC237457/; PubMed
The journal: https://conductscience.org/library/journal-index/0113724; PubMed
Citations, by iCite: 84; iCite
Relative citation ratio, by iCite: 2.94; iCite
Revised in PubMed: 2020-12-09; PubMed

Authors3

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Talarico CL	C L
2	Phelps WC	W C
3	Biron KK	K K

Source PubMed

Topics21

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Acquired Immunodeficiency Syndrome	Major topic
Acyclovir	Major topic
Genes, Viral	Major topic
Herpesviridae Infections	Major topic
Herpesvirus 3, Human	Major topic
Thymidine Kinase	Major topic
AIDS-Related Opportunistic Infections
Amino Acid Sequence
Antiviral Agents
Arabinofuranosyluracil
Base Sequence
Drug Resistance, Microbial
Genetic Variation
Guanine
Humans
Molecular Sequence Data
Mutagenesis
Precipitin Tests
Sequence Analysis
Sequence Homology, Amino Acid
Viral Plaque Assay

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References52

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	1,646,585	Foscarnet therapy in five patients with AIDS and acyclovir-resistant varicella-zoster virus infection.	Ann Intern Med	1991	https://conductscience.org/library/papers/1646585	PubMed
2	7,036,816	Intravenous acyclovir to treat mucocutaneous herpes simplex virus infection after marrow transplantation: a double-blind trial.	Ann Intern Med	1982	https://conductscience.org/library/papers/7036816	PubMed
3	1,653,394	Inhibition of DNA synthesis in varicella-zoster virus-infected cells by BV-araU.	Microbiol Immunol	1991	https://conductscience.org/library/papers/1653394	PubMed
4	1,658,351	Mutant varicella-zoster virus thymidine kinase: correlation of clinical resistance and enzyme impairment.	J Virol	1991	https://conductscience.org/library/papers/1658351	PubMed
5	1,666,496	In vitro and in vivo characterization of herpes simplex virus clinical isolates recovered from patients infected with human immunodeficiency virus.	Antimicrob Agents Chemother	1991	https://conductscience.org/library/papers/1666496	PubMed
6	2,543,763	The role of herpes simplex virus type 1 thymidine kinase in pathogenesis.	J Gen Virol	1989	https://conductscience.org/library/papers/2543763	PubMed
7	202,961	Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl) guanine.	Proc Natl Acad Sci U S A	1977	https://conductscience.org/library/papers/202961	PubMed
8	232,189	Inhibition of herpes simplex virus-induced DNA polymerase activity and viral DNA replication by 9-(2-hydroxyethoxymethyl)guanine and its triphosphate.	J Virol	1979	https://conductscience.org/library/papers/232189	PubMed
9	6,246,531	Two distinct loci confer resistance to acycloguanosine in herpes simplex virus type 1.	Proc Natl Acad Sci U S A	1980	https://conductscience.org/library/papers/6246531	PubMed
10	6,246,532	Resistance of herpes simplex virus to acycloguanosine: role of viral thymidine kinase and DNA polymerase loci.	Proc Natl Acad Sci U S A	1980	https://conductscience.org/library/papers/6246532	PubMed

1 to 10 of 52

See all 52 references

Cited by22

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 84 citations.

PMID	Title	Journal	Year	In Papers	Source
34,258,735	Antiviral Drugs Against Herpesviruses.	Adv Exp Med Biol	2021	https://conductscience.org/library/papers/34258735	PubMed
33,672,709	Advances and Perspectives in the Management of Varicella-Zoster Virus Infections.	Molecules	2021	https://conductscience.org/library/papers/33672709	PubMed
32,097,670	Favipiravir, an anti-influenza drug against life-threatening RNA virus infections.	Pharmacol Ther	2020	https://conductscience.org/library/papers/32097670	PubMed
30,858,222	Differences in the Likelihood of Acyclovir Resistance-Associated Mutations in the Thymidine Kinase Genes of Herpes Simplex Virus 1 and Varicella-Zoster Virus.	Antimicrob Agents Chemother	2019	https://conductscience.org/library/papers/30858222	PubMed
22,190,713	In vitro-selected drug-resistant varicella-zoster virus mutants in the thymidine kinase and DNA polymerase genes yield novel phenotype-genotype associations and highlight differences between antiherpesvirus drugs.	J Virol	2012	https://conductscience.org/library/papers/22190713	PubMed
16,982,796	Thymidine kinase mutations conferring acyclovir resistance in herpes simplex type 1 recombinant viruses.	Antimicrob Agents Chemother	2006	https://conductscience.org/library/papers/16982796	PubMed
15,965,615	Mutation hot spots in the canine herpesvirus thymidine kinase gene.	Virus Genes	2005	https://conductscience.org/library/papers/15965615	PubMed
12,525,621	Amino acid changes within conserved region III of the herpes simplex virus and human cytomegalovirus DNA polymerases confer resistance to 4-oxo-dihydroquinolines, a novel class of herpesvirus antiviral agents.	J Virol	2003	https://conductscience.org/library/papers/12525621	PubMed
11,353,604	Selection and characterization of varicella-zoster virus variants resistant to (R)-9-[4-hydroxy-2-(hydroxymethy)butyl]guanine.	Antimicrob Agents Chemother	2001	https://conductscience.org/library/papers/11353604	PubMed
11,160,674	Characterization of herpes simplex viruses selected in culture for resistance to penciclovir or acyclovir.	J Virol	2001	https://conductscience.org/library/papers/11160674	PubMed

1 to 10 of 22

See all 22 cited by

Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this paper from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/papers/v1/8380452

GET https://conductscience.org/api/papers/v1/8380452/references?page=2

API reference For AI assistants