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Paper · 8433729

Familial hyperglycemia due to mutations in glucokinase. Definition of a subtype of diabetes mellitus.

Froguel P and 9 others. N Engl J Med, 1993. Cited by 645 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Familial hyperglycemia due to mutations in glucokinase. Definition of a subtype of diabetes mellitus. Papers, record 8433729. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/8433729

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Familial hyperglycemia due to mutations in glucokinase. Definition of a subtype of diabetes mellitus.
PubMed
Journal
N Engl J Med
PubMed
Year
1993
PubMed
Publication types
Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
645
iCite
Relative citation ratio, by iCite
15.1
iCite
Revised in PubMed
2010-11-18
PubMed

Authors10

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Froguel PP
2Zouali HH
3Vionnet NN
4Velho GG
5Vaxillaire MM
6Sun FF
7Lesage SS
8Stoffel MM
9Takeda JJ
10Passa PP

Source PubMed

Topics21

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Diabetes Mellitus, Type 2Major topic
GlucokinaseMajor topic
HyperglycemiaMajor topic
Adult
Age Factors
Base Sequence
Blood Glucose
Child
DNA
Exons
Female
Genetic Linkage
Glucose Tolerance Test
Humans
Infant
Male
Middle Aged
Molecular Sequence Data
Mutation
Polymerase Chain Reaction
Polymorphism, Genetic

Source PubMed

Grants4

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
DK-16746NIDDK NIH HHSUnited StatesR01DK016746PubMed and NIHNIH RePORTER
DK-20595NIDDK NIH HHSUnited StatesP60DK020595PubMed and NIHNIH RePORTER
DK-44840NIDDK NIH HHSUnited StatesP01DK044840PubMed and NIHNIH RePORTER
R37DK016746NIHNIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections1

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

KindPMIDTitleIn Papers
Comment in8,433,735A defective beta-cell glucose sensor as a cause of diabetes.https://conductscience.org/library/papers/8433735

Source PubMed

References0

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

None in this release.

Cited by159

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 645 citations.

PMIDTitleJournalYearIn PapersSource
41,555,777Unraveling A-β+ ketosis-prone diabetes: An evolving diagnosis with an elusive pathogenesis.J Diabetes Investig2026https://conductscience.org/library/papers/41555777PubMed
40,166,432Decoding MODY: exploring genetic roots and clinical pathways.Diabetol Int2025https://conductscience.org/library/papers/40166432PubMed
39,571,094The IsletTester Mouse: An Immunodeficient Model With Stable Hyperglycemia for the Study of Human Islets.Diabetes2025https://conductscience.org/library/papers/39571094PubMed
39,420,902Clinical screening for GCK-MODY in 2,989 patients from the Brazilian Monogenic Diabetes Study Group (BRASMOD) and the Brazilian Type 1 Diabetes Study Group (BrazDiab1SG).Arch Endocrinol Metab2024https://conductscience.org/library/papers/39420902PubMed
39,245,718Glucokinase (GCK) in diabetes: from molecular mechanisms to disease pathogenesis.Cell Mol Biol Lett2024https://conductscience.org/library/papers/39245718PubMed
38,862,980Exploring histone deacetylases in type 2 diabetes mellitus: pathophysiological insights and therapeutic avenues.Clin Epigenetics2024https://conductscience.org/library/papers/38862980PubMed
38,222,792Genetic perspectives on childhood monogenic diabetes: Diagnosis, management, and future directions.World J Diabetes2023https://conductscience.org/library/papers/38222792PubMed
37,104,866The Rare and Atypical Diabetes Network (RADIANT) Study: Design and Early Results.Diabetes Care2023https://conductscience.org/library/papers/37104866PubMed
36,515,579The missing link between genetic association and regulatory function.Elife2022https://conductscience.org/library/papers/36515579PubMed
36,379,354Monitoring and modelling the dynamics of the cellular glycolysis pathway: A review and future perspectives.Mol Metab2022https://conductscience.org/library/papers/36379354PubMed

1 to 10 of 159

See all 159 cited by

Genes1

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn Genes
GCK2,645Swiss-Prot's referenceshttps://conductscience.org/library/genes/2645

Source NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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