Paper · 8599643

Sodium channel inactivation from closed states: evidence for an intrinsic voltage dependency.

Goldman L. Biophys J, 1995. Cited by 28 papers, by iCite.

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ConductScience Library. Sodium channel inactivation from closed states: evidence for an intrinsic voltage dependency. Papers, record 8599643. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/8599643

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Sodium channel inactivation from closed states: evidence for an intrinsic voltage dependency.; PubMed
Journal: Biophys J; PubMed
Year: 1995; PubMed
Publication types: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/8599643/; PubMed
DOI: https://doi.org/10.1016/s0006-3495(95)80106-2; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC1236474/; PubMed
The journal: https://conductscience.org/library/journal-index/0370626; PubMed
Citations, by iCite: 28; iCite
Relative citation ratio, by iCite: 0.74; iCite
Revised in PubMed: 2018-11-13; PubMed

Authors1

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	Kind	ORCID iD
1	Goldman L	L

Source PubMed

Topics11

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Sodium Channel Blockers	Major topic
Animals
Cell Line
Ion Channel Gating
Kinetics
Membrane Potentials
Neuroblastoma
Patch-Clamp Techniques
Probability
Time Factors
Tumor Cells, Cultured

Source PubMed

Grants1

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes it	Agency	Country	NIH project	Stated by
NS07734	NINDS NIH HHS	United States		PubMed

Source PubMed

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References17

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	6,094,703	Statistical properties of single sodium channels.	J Gen Physiol	1984	https://conductscience.org/library/papers/6094703	PubMed
2	19,431,799	Estimating the number of channels in patch recordings.	Biophys J	1991	https://conductscience.org/library/papers/19431799	PubMed
3	2,434,628	Voltage-dependent gating of single sodium channels from mammalian neuroblastoma cells.	J Neurosci	1987	https://conductscience.org/library/papers/2434628	PubMed
4	1,668,345	Sodium channel inactivation from resting states in guinea-pig ventricular myocytes.	J Physiol	1991	https://conductscience.org/library/papers/1668345	PubMed
5	6,288,838	Delays in inactivation development and activation kinetics in myxicola giant axons.	J Gen Physiol	1982	https://conductscience.org/library/papers/6288838	PubMed
6	2,720,064	A nonlinear cascade model for action potential encoding in an insect sensory neuron.	Biophys J	1989	https://conductscience.org/library/papers/2720064	PubMed
7	2,157,791	Kinetic analysis of single sodium channels from canine cardiac Purkinje cells.	J Gen Physiol	1990	https://conductscience.org/library/papers/2157791	PubMed
8	6,264,305	Sodium channels need not open before they inactivate.	Nature	1981	https://conductscience.org/library/papers/6264305	PubMed
9	7,381,770	The time course of sodium inactivation in squid giant axons.	J Physiol	1980	https://conductscience.org/library/papers/7381770	PubMed
10	6,268,217	Sodium channel inactivation in the crayfish giant axon. Must channels open before inactivating?	Biophys J	1981	https://conductscience.org/library/papers/6268217	PubMed

1 to 10 of 17

See all 17 references

Cited by16

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 28 citations.

PMID	Title	Journal	Year	In Papers	Source
41,003,497	Modification of Closed-State Inactivation in Voltage-Gated Sodium Channel Nav1.7 by Two Novel Arachnid Toxins.	Toxins (Basel)	2025	https://conductscience.org/library/papers/41003497	PubMed
34,963,066	Differential effects of modified batrachotoxins on voltage-gated sodium channel fast and slow inactivation.	Cell Chem Biol	2022	https://conductscience.org/library/papers/34963066	PubMed
34,347,027	Conformations of voltage-sensing domain III differentially define NaV channel closed- and open-state inactivation.	J Gen Physiol	2021	https://conductscience.org/library/papers/34347027	PubMed
32,542,050	Kilohertz waveforms optimized to produce closed-state Na+ channel inactivation eliminate onset response in nerve conduction block.	PLoS Comput Biol	2020	https://conductscience.org/library/papers/32542050	PubMed
27,489,371	Effect of phenytoin on sodium conductances in rat hippocampal CA1 pyramidal neurons.	J Neurophysiol	2016	https://conductscience.org/library/papers/27489371	PubMed
27,367,642	Dynamical characterization of inactivation path in voltage-gated Na(+) ion channel by non-equilibrium response spectroscopy.	Channels (Austin)	2016	https://conductscience.org/library/papers/27367642	PubMed
26,963,710	Parameterization for In-Silico Modeling of Ion Channel Interactions with Drugs.	PLoS One	2016	https://conductscience.org/library/papers/26963710	PubMed
18,299,396	Gating charge immobilization in Kv4.2 channels: the basis of closed-state inactivation.	J Gen Physiol	2008	https://conductscience.org/library/papers/18299396	PubMed
16,774,907	Quantitative analysis of a fully generalized four-state kinetic scheme.	Biophys J	2006	https://conductscience.org/library/papers/16774907	PubMed
16,456,723	Membrane effects of the n-3 fish oil fatty acids, which prevent fatal ventricular arrhythmias.	J Membr Biol	2005	https://conductscience.org/library/papers/16456723	PubMed

1 to 10 of 16

See all 16 cited by

Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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